Sandeep S. Dave

Journal Article Blood · September 5, 2024 Although initial therapy of mantle cell lymphoma (MCL) is not standardized, bendamustine plus rituximab (BR) is commonly used in older patients. Rituximab (R) maintenance after induction is often used. Thus, the open-label, randomized phase 2 ECOG-ACRIN Ca ... Full text Link to item Cite

Platelet RNA Biomarker of Ticagrelor-Responsive Genes Is Associated With Platelet Function and Cardiovascular Events.

Journal Article Arterioscler Thromb Vasc Biol · February 2024 BACKGROUND: Identifying patients with the optimal risk:benefit for ticagrelor is challenging. The aim was to identify ticagrelor-responsive platelet transcripts as biomarkers of platelet function and cardiovascular risk. METHODS: Healthy volunteers (n=58, ... Full text Link to item Cite

Leukemic presentation and progressive genomic alterations of MCD/C5 diffuse large B-cell lymphoma (DLBCL).

Journal Article Cold Spring Harb Mol Case Stud · December 2023 Diffuse large B-cell lymphoma (DLBCL) is a heterogenous group of lymphoid malignancies. Based on gene expression profiling, it has been subdivided into germinal center (GC)-derived and activated B-cell (ABC) types. Advances in molecular methodologies have ... Full text Link to item Cite

Burkitt lymphoma genomic discovery studies, drivers, and validation.

Journal Article Blood · September 7, 2023 Full text Link to item Cite

Correction: "The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" Leukemia. 2022 Jul;36(7):1720-1748.

Journal Article Leukemia · September 2023 Full text Link to item Cite

Addendum: LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair.

Journal Article Oncotarget · July 20, 2023 Full text Link to item Cite

LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair.

Journal Article Oncotarget · June 12, 2023 Despite advances in therapies treating non-Hodgkin's lymphoma (NHL), 20~40% of patients experience relapsed or refractory disease. While solid tumors with homologous recombination deficiencies have been successfully targeted with synthetic lethal agents su ... Full text Link to item Cite

Progression and transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma and B-cell prolymphocytic leukemia: Report from the 2021 SH/EAHP Workshop.

Journal Article Am J Clin Pathol · June 1, 2023 OBJECTIVES: Session 3 of the 2021 Workshop of the Society for Hematopathology/European Association for Haematopathology examined progression and transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and B-cell prolymphocytic l ... Full text Link to item Cite

Progression of Hodgkin lymphoma and plasma cell neoplasms: Report from the 2021 SH/EAHP Workshop.

Journal Article Am J Clin Pathol · June 1, 2023 OBJECTIVES: To summarize cases submitted to the 2021 Society for Hematopathology/European Association for Haematopathology Workshop under the categories of progression of Hodgkin lymphoma, plasmablastic myeloma, and plasma cell myeloma. METHODS: The worksh ... Full text Link to item Cite

B-cell lineage neoplasms transdifferentiating into histiocytic/dendritic cell neoplasms: diversity, differentiation lineage, genomic alterations, and therapy: Report from the 2021 SH/EAHP Workshop.

Journal Article Am J Clin Pathol · June 1, 2023 OBJECTIVES: To report findings from the 2021 Society for Hematopathology/European Association for Haematopathology Workshop within the category of B-cell lineage neoplasms' transdifferentiation into histiocytic/dendritic cell neoplasms (HDCNs). METHODS: Th ... Full text Link to item Cite

Phenotypic and genotypic infidelity in B-lineage neoplasms, including transdifferentiation following targeted therapy: Report from the 2021 SH/EAHP Workshop.

Journal Article Am J Clin Pathol · June 1, 2023 OBJECTIVES: Session 2 of the 2021 Society for Hematopathology and European Association for Haematopathology Workshop collected examples of lineage infidelity and transdifferentiation in B-lineage neoplasms, including after targeted therapy. METHODS: Twenty ... Full text Link to item Cite

Progression of follicular lymphoma and related entities: Report from the 2021 SH/EAHP Workshop.

Journal Article Am J Clin Pathol · May 11, 2023 OBJECTIVES: The 2021 Society for Hematopathology and European Association for Haematopathology Workshop addressed the molecular and cytogenetic underpinnings of transformation and transdifferentiation in lymphoid neoplasms. METHODS: Session 4, "Transformat ... Full text Link to item Cite

Transdifferentiation, phenotypic infidelity, progression, and transformation in T/NK-cell neoplasms: Report from the 2021 SH/EAHP Workshop.

Journal Article Am J Clin Pathol · May 11, 2023 OBJECTIVES: Sessions 8 and 9 of the 2021 Society for Hematopathology and the European Association for Haematopathology Workshop aimed to collect examples of transdifferentiation, lineage infidelity, progression, and transformation in precursor and mature T ... Full text Link to item Cite

Transformations of marginal zone lymphomas and lymphoplasmacytic lymphomas: Report from the 2021 SH/EAHP Workshop.

Journal Article Am J Clin Pathol · April 26, 2023 OBJECTIVES: To summarize the conclusions of the 2021 Society for Hematopathology/European Association for Haematopathology workshop regarding transformations of marginal zone lymphoma (MZL) and lymphoplasmacytic lymphoma (LPL). METHODS: Nineteen cases were ... Full text Link to item Cite

Identifying molecular drivers of lymphomagenesis

Chapter · April 14, 2023 Genomic technologies have revolutionized the study of molecular drivers of lymphoma development. These studies have uncovered common as well as disease-specific lymphoma drivers that represent promising therapeutic targets; however, significant barriers to ... Full text Cite

MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma.

Journal Article Clin Lymphoma Myeloma Leuk · October 2022 Mantle cell lymphoma (MCL) is a rare and aggressive form of B-cell non-Hodgkin lymphoma (NHL). Approximately 40%-50% of MCL patients carry inactivating mutations in the gene ataxia telangiectasia mutated (ATM), a core component of the cell's DNA damage res ... Full text Link to item Cite

EBV-positive follicular lymphoma and concurrent EBV-negative diffuse large B-cell lymphoma illustrating branched evolution model and “Hit and Run” hypothesis

Journal Article Journal of Hematopathology · September 1, 2022 Epstein-Barr virus (EBV) is one of the most common viruses associated with multiple malignancies including hematopoietic, epithelial, and mesenchymal neoplasms. EBV is linked to B- and T-cell lymphomas, ranging from indolent to highly aggressive neoplasms. ... Full text Cite

SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis.

Journal Article Cancer Discov · July 6, 2022 UNLABELLED: SETD2 is the sole histone methyltransferase responsible for H3K36me3, with roles in splicing, transcription initiation, and DNA damage response. Homozygous disruption of SETD2 yields a tumor suppressor effect in various cancers. However, SETD2 ... Full text Link to item Cite

Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age.

Journal Article Nat Commun · July 6, 2022 While survival has improved for Burkitt lymphoma patients, potential differences in outcome between pediatric and adult patients remain unclear. In both age groups, survival remains poor at relapse. Therefore, we conducted a comparative study in a large pe ... Full text Link to item Cite

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms.

Journal Article Leukemia · July 2022 We herein present an overview of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid and histiocytic neoplasms will be presented in a separate accompanying article. Be ... Full text Link to item Cite

Randomized study of induction with bendamustine-rituximab ± bortezomib and maintenance with rituximab ± lenalidomide for MCL.

Platelet RNA Biomarker of Ticagrelor-Responsive Genes Is Associated With Platelet Function and Cardiovascular Events.

Leukemic presentation and progressive genomic alterations of MCD/C5 diffuse large B-cell lymphoma (DLBCL).

Burkitt lymphoma genomic discovery studies, drivers, and validation.

Journal Article Blood · September 7, 2023 Full text Link to item Cite

Correction: "The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" Leukemia. 2022 Jul;36(7):1720-1748.

Journal Article Leukemia · September 2023 Full text Link to item Cite

Addendum: LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair.

Journal Article Oncotarget · July 20, 2023 Full text Link to item Cite

LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair.

Progression and transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma and B-cell prolymphocytic leukemia: Report from the 2021 SH/EAHP Workshop.

Progression of Hodgkin lymphoma and plasma cell neoplasms: Report from the 2021 SH/EAHP Workshop.

B-cell lineage neoplasms transdifferentiating into histiocytic/dendritic cell neoplasms: diversity, differentiation lineage, genomic alterations, and therapy: Report from the 2021 SH/EAHP Workshop.

Phenotypic and genotypic infidelity in B-lineage neoplasms, including transdifferentiation following targeted therapy: Report from the 2021 SH/EAHP Workshop.

Progression of follicular lymphoma and related entities: Report from the 2021 SH/EAHP Workshop.

Transdifferentiation, phenotypic infidelity, progression, and transformation in T/NK-cell neoplasms: Report from the 2021 SH/EAHP Workshop.

Transformations of marginal zone lymphomas and lymphoplasmacytic lymphomas: Report from the 2021 SH/EAHP Workshop.

Identifying molecular drivers of lymphomagenesis

MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma.

EBV-positive follicular lymphoma and concurrent EBV-negative diffuse large B-cell lymphoma illustrating branched evolution model and “Hit and Run” hypothesis

SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis.

Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age.

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms.

Aspirin effects on platelet gene expression are associated with a paradoxical, increase in platelet function.

Journal Article Br J Clin Pharmacol · May 2022 Aspirin has known effects beyond inhibiting platelet cyclooxygenase-1 (COX-1) that have been incompletely characterized. Transcriptomics can comprehensively characterize the on- and off-target effects of medications. We used a systems pharmacogenomics appr ... Full text Link to item Cite

Lymphomas: molecular subsets and advances in therapeutics

Chapter · January 1, 2022 Lymphoma is the sixth most common cause of cancer death in any individual person in the United States and there are over 50 recognized individual lymphoma pathologic entities. Even within relatively common entities such as diffuse large B-cell lymphoma, th ... Full text Cite

The Genetic Landscape of Ocular Adnexa MALT Lymphoma Reveals Frequent Aberrations in NFAT and MEF2B Signaling Pathways.

Journal Article Cancer Res Commun · October 2021 A comprehensive constellation of somatic non-silent mutations and copy number (CN) variations in ocular adnexa marginal zone lymphoma (OAMZL) is unknown. By utilizing whole-exome sequencing in 69 tumors we define the genetic landscape of OAMZL. Mutations a ... Full text Link to item Cite

Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas.

Journal Article Proc Natl Acad Sci U S A · June 22, 2021 Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that typically causes asymptomatic infection but can promote B lymphoid tumors in the immune suppressed. In vitro, EBV infection of primary B cells stimulates glycolysis during immortalization into lymph ... Full text Link to item Cite

Phase 1 study of belinostat (PXD-101) and bortezomib (Velcade, PS-341) in patients with relapsed or refractory acute leukemia and myelodysplastic syndrome.

Journal Article Leuk Lymphoma · May 2021 We report the results of a phase 1 dose-escalation study of belinostat and bortezomib in adult patients with acute leukemia or MDS or CML with blast crisis. Thirty-eight patients received IV belinostat days 1-5 and 8-12 with IV bortezomib days 1, 4, 8, and ... Full text Link to item Cite

Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells.

Journal Article Cold Spring Harb Perspect Med · March 1, 2021 Non-Hodgkin lymphomas (NHLs) are a diverse group of entities, both clinically and molecularly. Here, we review the evolution of classification schemes in B-cell lymphoma, noting the now standard WHO classification system that is based on immune cell-of-ori ... Full text Link to item Cite

Enteropathy-associated and monomorphic epitheliotropic intestinal t-cell lymphomas

Chapter · February 19, 2021 This chapter describes the clinical, pathological, and genetic characteristics of enteropathy-associated T-cell lymphoma (EATL), monomorphic epitheliotropic intestinal T-cell lymphoma, and refractory celiac disease (RCD), a rare lymphoproliferative disorde ... Full text Cite

Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma.

Journal Article Front Oncol · 2021 Metabolic dysfunctions enabling increased nucleotide biosynthesis are necessary for supporting malignant proliferation. Our investigations indicate that upregulation of fatty acid synthase (FASN) and de novo lipogenesis, commonly observed in many cancers, ... Full text Link to item Cite

Identifying transcriptional profiles and evaluating prognostic biomarkers of HIV-associated diffuse large B-cell lymphoma from Malawi.

Journal Article Mod Pathol · August 2020 Lymphoma incidence in sub-Saharan Africa (SSA) is increasing due to HIV and population aging. Diffuse Large B-cell lymphoma (DLBCL), the most common lymphoma in SSA and worldwide, is highly associated with HIV, but molecular studies of HIV-associated DLBCL ... Full text Link to item Cite

Genome-defined African ancestry is associated with distinct mutations and worse survival in patients with diffuse large B-cell lymphoma.

Journal Article Cancer · August 1, 2020 BACKGROUND: Significant racial differences have been observed in the incidence and clinical outcomes of diffuse large B-cell lymphoma (DLBCL) in the United States, but to the authors' knowledge it remains unclear whether genomic differences contribute to t ... Full text Link to item Cite

Polatuzumab Vedotin: Honing in on Relapsed or Refractory Diffuse Large B-Cell Lymphoma.

Journal Article J Clin Oncol · January 10, 2020 Full text Link to item Cite

Whole Exome and Transcriptome Sequencing in 1042 Cases Reveals Distinct Clinically Relevant Genetic Subgroups of Follicular Lymphoma.

Journal Article Blood · November 13, 2019 DISCLOSURES: Koff: Burroughs Wellcome Fund: Research Funding; V Foundation: Research Funding; Lymphoma Research Foundation: Research Funding; American Association for Cancer Research: Research Funding. Leppä:Roche: Honoraria, Research Funding; Takeda: Hono ... Full text Link to item Cite

The whole-genome landscape of Burkitt lymphoma subtypes.

Journal Article Blood · November 7, 2019 Burkitt lymphoma (BL) is an aggressive, MYC-driven lymphoma comprising 3 distinct clinical subtypes: sporadic BLs that occur worldwide, endemic BLs that occur predominantly in sub-Saharan Africa, and immunodeficiency-associated BLs that occur primarily in ... Full text Link to item Cite

PD-L1 expression is low in large B-cell lymphoma with MYC or double-hit translocation.

Journal Article Hematol Oncol · October 2019 In large B-cell lymphoma (LBCL), MYC translocation and MYC/BCL2 or MYC/BCL6 double hit (DH) are associated with poor prognosis, and there is an unmet need for novel treatment targets in this patient group. Treatments targeting the PD-L1/PD-1 pathway are st ... Full text Link to item Cite

TET2 Deficiency Sets the Stage for B-cell Lymphoma.

Journal Article Cancer Discov · December 2018 TET2 is a well-established tumor suppressor in the context of myeloid malignancies, but its role in lymphoma development has been less clear. In this issue of Cancer Discovery, Dominguez and colleagues report that TET2 function is critical for germinal cen ... Full text Link to item Cite

Injury promotes sarcoma development in a genetically and temporally restricted manner.

Journal Article JCI Insight · October 18, 2018 Cancer results from the accumulation of genetic mutations in a susceptible cell of origin. We and others have also shown that injury promotes sarcoma development, but how injury cooperates with genetic mutations at the earliest stages of tumor formation is ... Full text Link to item Cite

Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma.

Journal Article Nat Commun · August 15, 2018 Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus. Our understanding of PEL is poor and therefore treatment strategies are lacking. To address this need, we conducted genome-wide CRISPR/Cas9 knockout screens in eight PEL ... Full text Link to item Cite

Genetic convergence of rare lymphomas.

Journal Article Curr Opin Hematol · July 2018 PURPOSE OF REVIEW: We review the genetic foundations of different rare lymphomas to examine their shared origins. These data indicate the potential application of genomics to improve the diagnosis and treatment of these rare diseases. RECENT FINDINGS: Next ... Full text Link to item Cite

Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection.

Journal Article PLoS Pathog · May 2018 Within the liver a single Plasmodium parasite transforms into thousands of blood-infective forms to cause malaria. Here, we use RNA-sequencing to identify host genes that are upregulated upon Plasmodium berghei infection of hepatocytes with the hypothesis ... Full text Open Access Link to item Cite

Id Proteins Suppress E2A-Driven Invariant Natural Killer T Cell Development prior to TCR Selection.

Journal Article Front Immunol · 2018 A family of transcription factors known as E proteins, and their antagonists, Id proteins, regulate T cell differentiation at critical developmental checkpoints. Id proteins promote the differentiation of conventional αβ T cells and suppress the expansion ... Full text Link to item Cite

Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: genomic features and potential therapeutic targets.

Journal Article Blood · October 19, 2017 The adult high-grade B-cell lymphomas sharing molecular features with Burkitt lymphoma (BL) are highly aggressive lymphomas with poor clinical outcome. High-resolution structural and functional genomic analysis of adult Burkitt lymphoma (BL) and high-grade ... Full text Link to item Cite

Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.

Journal Article Cell · October 5, 2017 Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity poses a major barrier to understanding the genetic basis of the disease and it ... Full text Link to item Cite

Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype.

Journal Article Oncogene · July 20, 2017 Diffuse large B-cell lymphoma (DLBCL) has been categorized into two molecular subtypes that have prognostic significance, namely germinal center B-cell like (GCB) and activated B-cell like (ABC). Although ABC-DLBCL has been associated with NF-κB activation ... Full text Link to item Cite

Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.

Journal Article Nat Commun · July 10, 2017 Genetically engineered mouse models that employ site-specific recombinase technology are important tools for cancer research but can be costly and time-consuming. The CRISPR-Cas9 system has been adapted to generate autochthonous tumours in mice, but how th ... Full text Link to item Cite

Human Mesenchymal Stem Cell-Educated Macrophages Are a Distinct High IL-6-Producing Subset that Confer Protection in Graft-versus-Host-Disease and Radiation Injury Models.

Journal Article Biol Blood Marrow Transplant · June 2017 Mesenchymal stem cells (MSCs) have immunosuppressive and tissue repair properties, but clinical trials using MSCs to prevent or treat graft-versus-host disease (GVHD) have shown mixed results. Macrophages (MØs) are important regulators of immunity and can ... Full text Link to item Cite

Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.

Journal Article J Exp Med · May 1, 2017 Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenc ... Full text Link to item Cite

Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors.

Journal Article J Immunol · April 15, 2017 Inhibitor of DNA binding (Id) proteins, including Id1-4, are transcriptional regulators involved in promoting cell proliferation and survival in various cell types. Although upregulation of Id proteins is associated with a broad spectrum of tumors, recent ... Full text Link to item Cite

The Genetic Basis of Hepatosplenic T-cell Lymphoma.

Journal Article Cancer Discov · April 2017 Hepatosplenic T-cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown. Through whole-exome sequencing of 68 HSTLs, we define recurrently mutated driver genes and copy-number alterations in the disease. Chromati ... Full text Link to item Cite

Clinical Applications of the Genomic Landscape of Aggressive Non-Hodgkin Lymphoma.

Journal Article J Clin Oncol · March 20, 2017 In this review, we examine the genomic landscapes of lymphomas that arise from B, T, and natural killer cells. Lymphomas represent a striking spectrum of clinical behaviors. Although some lymphomas are curable with standard therapy, the majority of the aff ... Full text Link to item Cite

Epstein-Barr Virus Induces Adhesion Receptor CD226 (DNAM-1) Expression during Primary B-Cell Transformation into Lymphoblastoid Cell Lines.

Journal Article mSphere · 2017 Epstein-Barr virus (EBV), an oncogenic herpesvirus, infects and transforms primary B cells into immortal lymphoblastoid cell lines (LCLs), providing a model for EBV-mediated tumorigenesis. EBV transformation stimulates robust homotypic aggregation, indicat ... Full text Link to item Cite

Origin of Non-Hodgkin Lymphoma

Chapter · January 1, 2017 Full text Cite

GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.

Journal Article Blood · June 2, 2016 GNA13 is the most frequently mutated gene in germinal center (GC)-derived B-cell lymphomas, including nearly a quarter of Burkitt lymphoma and GC-derived diffuse large B-cell lymphoma. These mutations occur in a pattern consistent with loss of function. We ... Full text Link to item Cite

A comprehensive joint analysis of the long and short RNA transcriptomes of human erythrocytes.

Journal Article BMC Genomics · November 16, 2015 BACKGROUND: Human erythrocytes are terminally differentiated, anucleate cells long thought to lack RNAs. However, previous studies have shown the persistence of many small-sized RNAs in erythrocytes. To comprehensively define the erythrocyte transcriptome, ... Full text Link to item Cite

SMRT Sequencing for Parallel Analysis of Multiple Targets and Accurate SNP Phasing.

Journal Article G3 (Bethesda) · October 23, 2015 Single-molecule real-time (SMRT) sequencing generates much longer reads than other widely used next-generation (next-gen) sequencing methods, but its application to whole genome/exome analysis has been limited. Here, we describe the use of SMRT sequencing ... Full text Link to item Cite

The Role of EBV in the Pathogenesis of Diffuse Large B Cell Lymphoma.

Journal Article Curr Top Microbiol Immunol · 2015 Epstein-Barr virus (EBV) infection is a common feature of B cell lymphoproliferative disorders (LPDs), including diffuse large B cell lymphoma. Approximately 10 % of DLBCLs are EBV-positive, with the highest incidence in immunocompromised and elderly patie ... Full text Link to item Cite

Molecular subtype classification of formalin-fixed, paraffin-embedded diffuse large B-cell lymphoma samples on the ICEPlex® system.

Journal Article Br J Haematol · October 2014 Full text Link to item Cite

New clues to the molecular pathogenesis of Burkitt lymphoma revealed through next-generation sequencing.

Journal Article Curr Opin Hematol · July 2014 PURPOSE OF REVIEW: Burkitt lymphoma is an important clinical and model disease arising from B cells. Burkitt lymphoma is characterized by translocation of the c-MYC gene to an immunoglobulin enhancer region, resulting in enhanced cell proliferation and rap ... Full text Link to item Cite

Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib.

Journal Article N Engl J Med · June 12, 2014 BACKGROUND: Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK) and is effective in chronic lymphocytic leukemia (CLL). Resistance to irreversible kinase inhibitors and resistance associated with BTK inhibition have not been characteri ... Full text Link to item Cite

The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells.

Journal Article Blood · May 8, 2014 In this study, we define the genetic landscape of mantle cell lymphoma (MCL) through exome sequencing of 56 cases of MCL. We identified recurrent mutations in ATM, CCND1, MLL2, and TP53. We further identified a number of novel genes recurrently mutated in ... Full text Link to item Cite

The polyphony of BACH2.

Journal Article Blood · February 13, 2014 In this issue of Blood, Huang and colleagues examine the role of BACH2, a transcription factor known to be expressed highly in germinal center B cells.- ... Full text Link to item Cite

Merkel cell carcinoma with partial B-cell blastic immunophenotype: a potential mimic of cutaneous richter transformation in a patient with chronic lymphocytic lymphoma.

Journal Article Am J Dermatopathol · February 2014 Merkel cell polyomavirus (MCPyV) is a DNA virus whose pathogenic mechanisms in Merkel cell carcinoma (MCC) are still being unraveled. Emerging reports of an association between MCPyV and chronic lymphocytic lymphoma (CLL) have begun to broaden our understa ... Full text Link to item Cite

Lymphomas

Journal Article · August 29, 2013 Full text Cite

Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL.

Journal Article Cancer Res · August 15, 2013 Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype, and fewer than half of patients are cured with standard first-line therapy. To improve therapeutic options, better animal models that accurately mimic human DLBCL (hDLBCL) are neede ... Full text Link to item Cite

PAK1 mediates resistance to PI3K inhibition in lymphomas.

Journal Article Clin Cancer Res · March 1, 2013 PURPOSE: The phosphoinositide 3-kinase (PI3K) pathway is known to play an active role in many malignancies. The role of PI3K inhibition in the treatment of lymphomas has not been fully delineated. We sought to identify a role for therapeutic PI3K inhibitio ... Full text Link to item Cite

Biomimetic, synthetic HDL nanostructures for lymphoma.

Journal Article Proc Natl Acad Sci U S A · February 12, 2013 New therapies that challenge existing paradigms are needed for the treatment of cancer. We report a nanoparticle-enabled therapeutic approach to B-cell lymphoma using synthetic high density lipoprotein nanoparticles (HDL-NPs). HDL-NPs are synthesized using ... Full text Link to item Cite

Genetic heterogeneity of diffuse large B-cell lymphoma.

Journal Article Proc Natl Acad Sci U S A · January 22, 2013 Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma in adults. The disease exhibits a striking heterogeneity in gene expression profiles and clinical outcomes, but its genetic causes remain to be fully defined. Through whole genome an ... Full text Link to item Cite

Genomic stratification for the treatment of lymphomas.

Journal Article Hematology Am Soc Hematol Educ Program · 2013 The application of high-throughput genomic approaches in lymphomas has generated a wealth of data regarding the molecular underpinnings of these cancers. In this review, key findings from recent studies are discussed, as well as the genetic heterogeneity t ... Full text Link to item Cite

Origin of Non-Hodgkin Lymphoma

Chapter · 2013 This leading text reflects both the new direction and explosive growth of the field of hematology. ... Cite

MicroRNA expression profiling using microarrays.

Journal Article Methods Mol Biol · 2013 MicroRNAs are small noncoding RNAs which are able to regulate gene expression at both the transcriptional and translational levels. There is a growing recognition of the role of microRNAs in nearly every tissue type and cellular process. Thus there is an i ... Full text Link to item Cite

The genetic landscape of mutations in Burkitt lymphoma.

Journal Article Nat Genet · December 2012 Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the sam ... Full text Link to item Cite

Lymphomas

Chapter · November 15, 2012 Full text Cite

Analysis of Epstein-Barr virus-regulated host gene expression changes through primary B-cell outgrowth reveals delayed kinetics of latent membrane protein 1-mediated NF-κB activation.

Journal Article J Virol · October 2012 Epstein-Barr virus (EBV) is an oncogenic human herpesvirus that dramatically reorganizes host gene expression to immortalize primary B cells. In this study, we analyzed EBV-regulated host gene expression changes following primary B-cell infection, both dur ... Full text Open Access Link to item Cite

The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells.

Journal Article J Virol · June 2012 Epstein-Barr virus (EBV) infection of primary human B cells drives their indefinite proliferation into lymphoblastoid cell lines (LCLs). B cell immortalization depends on expression of viral latency genes, as well as the regulation of host genes. Given the ... Full text Open Access Link to item Cite

Molecular characterization of circulating plasma cells in patients with active systemic lupus erythematosus.

Journal Article PLoS One · 2012 Systemic lupus erythematosus (SLE) is a generalized autoimmune disease characterized by abnormal B cell activation and the occurrence of increased frequencies of circulating plasma cells (PC). The molecular characteristics and nature of circulating PC and ... Full text Link to item Cite

Burkitt lymphoma: analysis of the genome.

Journal Article Clin Adv Hematol Oncol · January 2012 Link to item Cite

Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.

Journal Article Cell Host Microbe · November 17, 2011 Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency ... Full text Link to item Cite

Immunophenotypic and gene expression analysis of monoclonal B-cell lymphocytosis shows biologic characteristics associated with good prognosis CLL.

Journal Article Leukemia · September 2011 Monoclonal B-cell lymphocytosis (MBL) is a hematologic condition wherein small B-cell clones can be detected in the blood of asymptomatic individuals. Most MBL have an immunophenotype similar to chronic lymphocytic leukemia (CLL), and 'CLL-like' MBL is a p ... Full text Link to item Cite

HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis.

Journal Article Cancer Res · July 1, 2011 HER2 overexpression occurs in approximately 25% of breast cancers, where it correlates with poor prognosis. Likewise, systemic inflammation in breast cancer correlates with poor prognosis, although the process is not understood. In this study, we explored ... Full text Link to item Cite

Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.

Journal Article Am J Surg Pathol · February 2011 The normal counterparts of mantle cell lymphoma (MCL) are naive, quiescent B cells that have not been processed through the germinal center (GC). For this reason, although lymphomas arising from GC or post-GC B cells often exhibit plasmacytic differentiati ... Full text Open Access Link to item Cite

An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells.

Journal Article Cell Host Microbe · December 16, 2010 Epstein-Barr virus (EBV), an oncogenic herpesvirus that causes human malignancies, infects and immortalizes primary human B cells in vitro into indefinitely proliferating lymphoblastoid cell lines, which represent a model for EBV-induced tumorigenesis. The ... Full text Link to item Cite

Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs.

Journal Article Blood · December 2, 2010 A role for microRNA (miRNA) has been recognized in nearly every biologic system examined thus far. A complete delineation of their role must be preceded by the identification of all miRNAs present in any system. We elucidated the complete small RNA transcr ... Full text Link to item Cite

Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling.

Journal Article Blood · August 12, 2010 The genome of mantle cell lymphoma (MCL) is, in addition to the translocation t(11;14), characterized by a high number of secondary chromosomal gains and losses that probably account for the various survival times of MCL patients. We investigated 77 primar ... Full text Link to item Cite

Host factors for risk and survival in lymphoma.

Journal Article Hematology Am Soc Hematol Educ Program · 2010 All cancers arise from complex interactions between aspects of the patient (host) biology and the environment. Once tumors arise, they frequently remain dependent on interactions with their microenvironment for their growth and proliferation. In this revie ... Full text Link to item Cite

SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype.

Journal Article Haematologica · November 2009 BACKGROUND: Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-cell lymphomas. The clinical and pathological characteristics of patients with this form of lymphoma have not been well defined. Overexpression of the transc ... Full text Link to item Cite

Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma.

Journal Article Blood · June 11, 2009 Gene expression profiling of diffuse large B-cell lymphoma (DLBCL) has revealed distinct molecular subtypes that include germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL. ABC DLBCL has a worse survival after upfront chemotherapy and ... Full text Link to item Cite

Patterns of microRNA expression characterize stages of human B-cell differentiation.

Journal Article Blood · May 7, 2009 Mature B-cell differentiation provides an important mechanism for the acquisition of adaptive immunity. Malignancies derived from mature B cells constitute the majority of leukemias and lymphomas. These malignancies often maintain the characteristics of th ... Full text Link to item Cite

Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting.

Journal Article Blood · April 16, 2009 Subjects with X-linked hyper-IgM syndrome (X-HIgM) have a markedly reduced frequency of CD27(+) memory B cells, and their Ig genes have a low level of somatic hypermutation (SHM). To analyze the nature of SHM in X-HIgM, we sequenced 209 nonproductive and 9 ... Full text Link to item Cite

Stromal gene signatures in large-B-cell lymphomas.

Journal Article N Engl J Med · November 27, 2008 BACKGROUND: The addition of rituximab to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), or R-CHOP, has significantly improved the survival of patients with diffuse large-B-cell lymphoma. Whether gene-expres ... Full text Link to item Cite

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways.

Journal Article Proc Natl Acad Sci U S A · September 9, 2008 Gene-expression profiling has been used to define 3 molecular subtypes of diffuse large B-cell lymphoma (DLBCL), termed germinal center B-cell-like (GCB) DLBCL, activated B-cell-like (ABC) DLBCL, and primary mediastinal B-cell lymphoma (PMBL). To investiga ... Full text Link to item Cite

Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma.

Journal Article Haematologica · September 2008 BACKGROUND: Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt's lymphoma, but also demonstrated that a su ... Full text Link to item Cite

IRF4 addiction in multiple myeloma.

Journal Article Nature · July 10, 2008 The transcription factor IRF4 (interferon regulatory factor 4) is required during an immune response for lymphocyte activation and the generation of immunoglobulin-secreting plasma cells. Multiple myeloma, a malignancy of plasma cells, has a complex molecu ... Full text Link to item Cite

Follicular lymphoma and the microenvironment.

Journal Article Blood · May 1, 2008 Full text Link to item Cite

Oncogenic CARD11 mutations in human diffuse large B cell lymphoma.

Journal Article Science · March 21, 2008 Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. In the least curable (ABC) subtype of DLBCL, survival of the malignant cells is dependent on constitutive activation of the nuclear factor-kappaB (NF-kappaB) signaling ... Full text Link to item Cite

In reply [2]

Journal Article Journal of Clinical Oncology · October 20, 2007 Full text Cite

Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.

Journal Article Cancer Cell · August 2007 Mechanisms of constitutive NF-kappaB signaling in multiple myeloma are unknown. An inhibitor of IkappaB kinase beta (IKKbeta) targeting the classical NF-kappaB pathway was lethal to many myeloma cell lines. Several cell lines had elevated expression of NIK ... Full text Link to item Cite

Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas.

Journal Article J Clin Oncol · August 1, 2007 PURPOSE: Nodal peripheral T-cell lymphomas (PTCLs) constitute a heterogeneous group of neoplasms, suggesting the existence of molecular differences contributing to their histologic and clinical variability. Initial expression profiling studies of T-cell ly ... Full text Link to item Cite

Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma.

Journal Article J Exp Med · March 19, 2007 To elucidate the mechanisms underlying chromosomal translocations in diffuse large B cell lymphoma (DLBCL), we investigated the nature and extent of immunoglobulin class switch recombination (CSR) in these tumors. We used Southern blotting to detect legiti ... Full text Link to item Cite

Drs. Dave and Staudt reply [5]

Journal Article New England Journal of Medicine · September 7, 2006 Full text Cite

Gene expression signatures and outcome prediction in mature B-cell malignancies.

Journal Article Curr Treat Options Oncol · July 2006 Non-Hodgkin's lymphomas comprise a diverse group of diseases that are subclassified by the state of differentiation of the malignant B cells, presence of specific cytogenetic abnormalities, and characteristic morphology. Gene expression profiling has revea ... Full text Link to item Cite

Molecular diagnosis of Burkitt's lymphoma.

Journal Article N Engl J Med · June 8, 2006 BACKGROUND: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is crucial because these two types of lymphoma require different treatments. We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphom ... Full text Link to item Cite

A loss-of-function RNA interference screen for molecular targets in cancer.

Journal Article Nature · May 4, 2006 The pursuit of novel therapeutic agents in cancer relies on the identification and validation of molecular targets. Hallmarks of cancer include self-sufficiency in growth signals and evasion from apoptosis; genes that regulate these processes may be optima ... Full text Link to item Cite

Gene expression profiling and outcome prediction in non-Hodgkin lymphoma.

Journal Article Biol Blood Marrow Transplant · January 2006 Gene expression profiling with microarrays has provided new insights into the molecular biology of tumors can that underlie differences in responses to therapy and patient outcomes. In diffuse large B-cell lymphoma, gene expression profiling has revealed a ... Full text Link to item Cite

Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling.

Journal Article Blood · December 15, 2005 Cyclin D1 overexpression is believed to be essential in the pathogenesis of mantle cell lymphoma (MCL). Hence, the existence of cyclin D1-negative MCL has been controversial and difficult to substantiate. Our previous gene expression profiling study identi ... Full text Link to item Cite

Immune signatures in follicular lymphoma.

Journal Article N Engl J Med · April 7, 2005 Link to item Cite

Lymphoma-infiltrating immune cells.

Journal Article N Engl J Med · February 17, 2005 Link to item Cite

The biology of human lymphoid malignancies revealed by gene expression profiling.

Journal Article Adv Immunol · 2005 Gene expression profiling provides a quantitative molecular framework for the study of human lymphomas. This genomic technology has revealed that existing diagnostic categories are comprised of multiple molecularly and clinically distinct diseases. Diffuse ... Full text Link to item Cite

Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells.

Journal Article N Engl J Med · November 18, 2004 BACKGROUND: Patients with follicular lymphoma may survive for periods of less than 1 year to more than 20 years after diagnosis. We used gene-expression profiles of tumor-biopsy specimens obtained at diagnosis to develop a molecular predictor of the length ... Full text Link to item Cite

BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma.

Journal Article Am J Pathol · July 2004 Gene expression profiling of diffuse large B-cell lymphoma (DLBCL) has revealed prognostically important subgroups: germinal center B-cell-like (GCB) DLBCL, activated B cell-like (ABC) DLBCL, and primary mediastinal large B-cell lymphoma. The t(14;18)(q32; ... Full text Link to item Cite

Cost-effectiveness considerations in the treatment of essential thrombocythemia.

Journal Article Semin Oncol · June 2002 Factors that influence the choice of anagrelide, hydroxyurea, or interferon-alfa (IFN-alpha) for treatment of essential thrombocythemia include efficacy, toxicity, and cost. Anagrelide has the US Food and Drug Administration's approval to be used for treat ... Full text Link to item Cite

Prognosis in familial amyotrophic lateral sclerosis: progression and survival in patients with glu100gly and ala4val mutations in Cu,Zn superoxide dismutase.

Journal Article Neurology · January 1997 Familial amyotrophic lateral sclerosis (FALS) is an autosomal dominant neurodegenerative disorder affecting motor neurons and is associated with mutations in the Cu,Zn superoxide dismutase gene (SOD1) in a subset (approximately 15%) of FALS families. We an ... Full text Link to item Cite

ATP receptor activation potentiates a voltage-dependent Ca channel in hippocampal neurons.

Journal Article Brain Res · April 9, 1996 Activation of a purinergic P2 receptor by adenosine 5'-triphosphate (ATP) has previously been shown to open a non-selective cation channel with a reversal potential of approximately 0 mV. We examined the effect of P2 receptor activation on voltage-gated io ... Full text Link to item Cite