Scholars@Duke
Stephen Patrick Bergin

Stephen Patrick Bergin

Associate Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
DUMC 2629, 203 Research Dr MSRB1 Ste. 201B, Durham, NC 27710
DUMC 2629, 203 Research Dr MSRB1 Ste. 201B, Durham, NC 27710

Selected Publications

Evaluation of the safety profile and intrapulmonary pharmacokinetics of intravenous fosfomycin in healthy adults.

Journal Article Antimicrob Agents Chemother · January 8, 2025 UNLABELLED: This Phase 1 trial described the intrapulmonary pharmacokinetics and safety profile of IV fosfomycin in healthy participants. Fosfomycin, a broad-spectrum antibiotic mainly used to treat urinary tract infections, is being considered for treatme ... Full text Link to item Cite

Cost-Effectiveness of Plasma Microbial Cell-Free DNA Sequencing When Added to Usual Care Diagnostic Testing for Immunocompromised Host Pneumonia.

Journal Article Pharmacoeconomics · September 2024 INTRODUCTION: Immunocompromised host pneumonia (ICHP) is an important cause of morbidity and mortality, yet usual care (UC) diagnostic tests often fail to identify an infectious etiology. A US-based, multicenter study (PICKUP) among ICHP patients with hema ... Full text Link to item Cite

Clinical Utility of Plasma Microbial Cell-Free DNA Sequencing Among Immunocompromised Patients With Pneumonia.

Journal Article Open Forum Infect Dis · August 2024 BACKGROUND: Plasma microbial cell-free DNA (mcfDNA) sequencing can establish the etiology of multiple infectious syndromes by identifying microbial DNA in plasma. However, data are needed to define the clinical scenarios where this tool offers the highest ... Full text Link to item Cite

Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Patients With Pneumonia: A Prospective Observational Study.

Journal Article Clin Infect Dis · March 20, 2024 BACKGROUND: Pneumonia is a common cause of morbidity and mortality, yet a causative pathogen is identified in a minority of cases. Plasma microbial cell-free DNA sequencing may improve diagnostic yield in immunocompromised patients with pneumonia. METHODS: ... Full text Link to item Cite

PROPHETIC EU: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit in European and United States Cohorts.

Journal Article Open Forum Infect Dis · July 2022 BACKGROUND: The prospective identification of patients at high risk for hospital-acquired/ventilator-associated bacterial pneumonia may improve clinical trial feasibility and foster antibacterial development. In a prior study conducted in the United States ... Full text Open Access Link to item Cite

Aspiration Risk Factors, Microbiology, and Empiric Antibiotics for Patients Hospitalized With Community-Acquired Pneumonia.

Journal Article Chest · January 2021 BACKGROUND: Aspiration community-acquired pneumonia (ACAP) and community-acquired pneumonia (CAP) in patients with aspiration risk factors (AspRFs) are infections associated with anaerobes, but limited evidence suggests their pathogenic role. RESEARCH QUES ... Full text Open Access Link to item Cite

PROPHETIC: Prospective Identification of Pneumonia in Hospitalized Patients in the ICU.

Journal Article Chest · December 2020 BACKGROUND: Pneumonia is the leading infection-related cause of death. The use of simple clinical criteria and contemporary epidemiology to identify patients at high risk of nosocomial pneumonia should enhance prevention efforts and facilitate development ... Full text Open Access Link to item Cite

Correction to: Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective.

Journal Article BMC Infect Dis · October 13, 2020 An amendment to this paper has been published and can be accessed via the original article. ... Full text Link to item Cite

Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia.

Journal Article Respirology · May 2020 BACKGROUND AND OBJECTIVE: Enterobacteriaceae (EB) spp. family is known to include potentially multidrug-resistant (MDR) microorganisms, and remains as an important cause of community-acquired pneumonia (CAP) associated with high mortality. The aim of this ... Full text Link to item Cite

The robust and rapid role of molecular testing in precision fungal diagnostics: A case report.

Journal Article Med Mycol Case Rep · March 2020 Diagnosis of invasive fungal disease remains an ongoing challenge for clinicians, while continuously evolving treatment regimens increase patient risk for invasive infection. This case highlights how molecular testing led to the diagnosis of co-infection w ... Full text Link to item Cite

International prevalence and risk factors evaluation for drug-resistant Streptococcus pneumoniae pneumonia.

Journal Article J Infect · October 2019 OBJECTIVE: Streptococcus pneumoniae is the most frequent bacterial pathogen isolated in subjects with Community-acquired pneumonia (CAP) worldwide. Limited data are available regarding the current global burden and risk factors associated with drug-resista ... Full text Open Access Link to item Cite

Prevalence and Etiology of Community-acquired Pneumonia in Immunocompromised Patients.

Journal Article Clin Infect Dis · April 24, 2019 BACKGROUND: The correct management of immunocompromised patients with pneumonia is debated. We evaluated the prevalence, risk factors, and characteristics of immunocompromised patients coming from the community with pneumonia. METHODS: We conducted a secon ... Full text Open Access Link to item Cite

Ethylene Glycol Toxicity in the Setting of Recurrent Ingestion: A Case Report and Literature Review.

Journal Article Cureus · April 3, 2019 Ethylene glycol (EG) poisoning is a toxicologic emergency requiring high clinical suspicion and early diagnosis to prevent life-threatening complications. Direct EG quantification methods involve cumbersome and time-consuming laboratory tests of limited ut ... Full text Link to item Cite

An international perspective on hospitalized patients with viral community-acquired pneumonia.

Journal Article Eur J Intern Med · February 2019 BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverag ... Full text Open Access Link to item Cite

Microbiological testing of adults hospitalised with community-acquired pneumonia: an international study.

Journal Article ERJ Open Res · October 2018 This study aimed to describe real-life microbiological testing of adults hospitalised with community-acquired pneumonia (CAP) and to assess concordance with the 2007 Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) and 2011 Eur ... Full text Open Access Link to item Cite

Pediatric Antibacterial and Antifungal Trials From 2007 to 2017.

Journal Article Pediatrics · September 2018 BACKGROUND AND OBJECTIVES: The impact of the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) on pediatric antibacterial or antifungal drug trials is unknown. Our objective was to identify and characterize trials co ... Full text Open Access Link to item Cite

Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: a multinational point prevalence study of hospitalised patients.

Journal Article Eur Respir J · August 2018 Pseudomonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aerugin ... Full text Open Access Link to item Cite

Airway pressure release ventilation: a step forward?

Journal Article Intensive Care Med · February 2018 Full text Link to item Cite

Bacteremia, Sepsis, and Infective Endocarditis Associated with Staphylococcus aureus.

Journal Article Curr Top Microbiol Immunol · 2017 Bacteremia and infective endocarditis (IE) are important causes of morbidity and mortality associated with Staphylococcus aureus infections. Increasing exposure to healthcare, invasive procedures, and prosthetic implants has been associated with a rising i ... Full text Link to item Cite

Managing Respiratory Failure in Obstructive Lung Disease.

Journal Article Clin Chest Med · December 2016 Exacerbations of obstructive lung disease are common causes of acute respiratory failure. Short-acting bronchodilators and systemic glucocorticoids are the foundation of pharmacologic management. For patients requiring ventilator support, use of noninvasiv ... Full text Link to item Cite

Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study.

Journal Article Lancet Infect Dis · December 2016 BACKGROUND: Antibiotic resistance is a major global health problem and pathogens such as meticillin-resistant Staphylococcus aureus (MRSA) have become of particular concern in the management of lower respiratory tract infections. However, few data are avai ... Full text Open Access Link to item Cite

Survival Benefit of Empirical Therapy for Staphylococcus aureus Bloodstream Infections in Infants.

Journal Article Pediatr Infect Dis J · November 2015 BACKGROUND: The impact of early adequate empirical antibiotic therapy on outcomes of infants in the neonatal intensive care unit (NICU) who develop Staphylococcus aureus bloodstream infections (BSI) is unknown. METHODS: Infants with S. aureus BSI discharge ... Full text Link to item Cite

Neonatal Escherichia coli Bloodstream Infections: Clinical Outcomes and Impact of Initial Antibiotic Therapy.

Journal Article Pediatr Infect Dis J · September 2015 BACKGROUND: Escherichia coli is a common cause of bloodstream infections (BSIs) in infants and is associated with high mortality and morbidity among survivors. The clinical significance of antibiotic resistance and timing of appropriate antimicrobial thera ... Full text Link to item Cite