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PROPHETIC EU: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit in European and United States Cohorts.

Publication ,  Journal Article
Bergin, SP; Calvert, SB; Farley, J; Sun, J-L; Chiswell, K; Dieperink, W; Kluytmans, J; Lopez-Delgado, JC; Leon-Lopez, R; Zervos, MJ; Kollef, MH ...
Published in: Open Forum Infect Dis
July 2022

BACKGROUND: The prospective identification of patients at high risk for hospital-acquired/ventilator-associated bacterial pneumonia may improve clinical trial feasibility and foster antibacterial development. In a prior study conducted in the United States, clinical criteria were used to prospectively identify these patients; however, these criteria have not been applied in a European population. METHODS: Adults considered high risk for pneumonia (treatment with ventilation or high levels of supplemental oxygen) in the intensive care units of 7 European hospitals were prospectively enrolled from June 12 to December 27, 2017. We estimated the proportion of high-risk patients developing pneumonia according to US Food and Drug Administration guidance and a subset potentially eligible for antibacterial trial enrollment. We compared patient characteristics, treatment exposures, and pneumonia incidence in a European cohort and a previously described US cohort. RESULTS: Of 888 high-risk patients, 211/888 (24%) were treated for possible pneumonia, and 150/888 (17%) met the Food and Drug Administration definition for hospital-acquired/ventilator-associated bacterial pneumonia. A higher proportion of European patients treated for possible pneumonia met the pneumonia definition (150/211 [71%] vs 537/1464 [37%]; P < .001). Among patients developing pneumonia, a higher proportion of European patients met antibacterial trial eligibility criteria (124/150 [83%] vs 371/537 [69%]; P < .001). CONCLUSIONS: Clinical criteria prospectively identified high-risk patients with high rates of pneumonia in the European cohort. Despite higher rates of established risk factors and incident pneumonia, European patients were significantly less likely to receive antibiotics for possible pneumonia than US patients. Different treatment practices may contribute to lower rates of antibacterial trial enrollment in the United States.

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Published In

Open Forum Infect Dis

DOI

ISSN

2328-8957

Publication Date

July 2022

Volume

9

Issue

7

Start / End Page

ofac231

Location

United States

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences
 

Citation

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Chicago
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MLA
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Bergin, S. P., Calvert, S. B., Farley, J., Sun, J.-L., Chiswell, K., Dieperink, W., … Hullegie, S. J. (2022). PROPHETIC EU: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit in European and United States Cohorts. Open Forum Infect Dis, 9(7), ofac231. https://doi.org/10.1093/ofid/ofac231
Bergin, Stephen P., Sara B. Calvert, John Farley, Jie-Lena Sun, Karen Chiswell, Willem Dieperink, Jan Kluytmans, et al. “PROPHETIC EU: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit in European and United States Cohorts.Open Forum Infect Dis 9, no. 7 (July 2022): ofac231. https://doi.org/10.1093/ofid/ofac231.
Bergin SP, Calvert SB, Farley J, Sun J-L, Chiswell K, Dieperink W, et al. PROPHETIC EU: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit in European and United States Cohorts. Open Forum Infect Dis. 2022 Jul;9(7):ofac231.
Bergin, Stephen P., et al. “PROPHETIC EU: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit in European and United States Cohorts.Open Forum Infect Dis, vol. 9, no. 7, July 2022, p. ofac231. Pubmed, doi:10.1093/ofid/ofac231.
Bergin SP, Calvert SB, Farley J, Sun J-L, Chiswell K, Dieperink W, Kluytmans J, Lopez-Delgado JC, Leon-Lopez R, Zervos MJ, Kollef MH, Sims M, Kabchi BA, Rubin D, Santiago J, Natarajan M, Tenaerts P, Fowler VG, Holland TL, Bonten MJ, Hullegie SJ. PROPHETIC EU: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit in European and United States Cohorts. Open Forum Infect Dis. 2022 Jul;9(7):ofac231.
Journal cover image

Published In

Open Forum Infect Dis

DOI

ISSN

2328-8957

Publication Date

July 2022

Volume

9

Issue

7

Start / End Page

ofac231

Location

United States

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences