Scholars@Duke
Steven C. Grambow

Steven C. Grambow

Associate Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
steven.grambow@duke.edu
Duke Box 2734, Durham, NC 27710
2424 Erwin Road, Suite G06, Box 2734 Rm G027, Durham, NC 27705

Selected Publications

Improving Statistical Literacy for Physician Scientists: Sampling Distributions

Journal Article Journal of Curriculum and Teaching · November 15, 2024 This is the first in a multi-part series on teaching statistical inference to physician-scientists training to work as members of interdisciplinary scientific teams. This unique student audience has greater scientific sophistication than a typical ... Full text Cite

A Method for Teaching Biostatisticians to Write and Critique Specific Aims

Journal Article Journal of Curriculum and Teaching · November 1, 2024 This article describes the design of a single instructional module on writing and critiquing the Specific Aims (SA) section of a grant proposal for a biomedical research study. It begins by discussing the goals and learning objectives for the module. Then, ... Full text Cite

Effective Scientific Presentations Across Formats: A Modern Guide for Science Trainees and Researchers

Journal Article Advances in Social Sciences Research Journal · September 19, 2024 This paper presents a comprehensive tutorial on delivering effective scientific presentations in the modern era, addressing a landscape altered by the COVID-19 pandemic. The shift to virtual and hybrid formats has fundamentally changed the norms of ... Full text Cite

Accelerating resident research within quantitative collaboration units in academic healthcare

Journal Article Stat · June 1, 2024 With increased access to biomedical and electronic health records data and the complexity of research questions, individuals in residency programmes who aim to conduct research require specialized educational programmes and biostatistics support. Biostatis ... Full text Cite

Biomedical Researchers Should be Taught Statistics Differently than Biostatisticians in Training: Illustration of a Module within a Clinical Research Seminar Course

Journal Article Journal of Curriculum and Teaching · May 1, 2024 The predominant model for biomedical research is team science. Two critical members of the team are the clinical investigator and the biostatistician. Typically, the biostatistician performs statistical analyses and the clinical investigator interprets the ... Full text Cite

A Curriculum Review of Programming Courses in a Master of Biostatistics Program

Journal Article Journal of Curriculum and Teaching · February 1, 2024 Computing is a core competency for collaborative biostatisticians, who work on interdisciplinary scientific teams in medicine and publich health. However, computing is a broad field that encompases many underlying pedagogical constructs and subspeciality t ... Full text Cite

Treatment Effect Estimates From Pilot Trials Are Unreliable.

Journal Article J Pain Symptom Manage · December 2023 CONTEXT: The CONSORT guideline defines a pilot trial as a small-scale version of a desired future efficacy trial that is intended to answer the key questions of whether and how a larger study should be done. For example, a pilot trial might evaluate differ ... Full text Link to item Cite

A Visual Tool to Help Develop a Statistical Analysis Plan for Randomized Trials in Palliative Care.

Journal Article J Pain Symptom Manage · January 2023 Collaboration with a statistician about the design of a statistical analysis plan can be enhanced by illustrating how statisticians conceptualize their task. This conceptualization can be represented by a directed acyclic graph (DAG), which illustrates the ... Full text Link to item Cite

Advancing workforce diversity by leveraging the Clinical and Translational Science Awards (CTSA) program.

Journal Article J Clin Transl Sci · 2023 Clinical trials continue to disproportionately underrepresent people of color. Increasing representation of diverse backgrounds among clinical research personnel has the potential to yield greater representation in clinical trials and more efficacious medi ... Full text Link to item Cite

Are Simulated Coding Interviews a Fair and Practical Examination Format for Non-professional Programmers Enrolled in a Master's Degree Program in Biostatistics?

Journal Article Journal of Curriculum and Teaching · January 1, 2023 This report describes an innovative and evidence-based approach to implementing coding interviews as an examination format for non-professional programmers: namely, students in a Master of Biostatistics program taking a course in the language of SAS. In ad ... Full text Cite

Experiential Learning Methods for Biostatistics Students: A Model for Embedding Student Interns in Academic Health Centers.

Journal Article Stat · December 2022 This manuscript describes an experiential learning program for future collaborative biostatisticians (CBs) developed within an academic medical center. The program is a collaborative effort between the Biostatistics, Epidemiology, and Research Design (BERD ... Full text Link to item Cite

Secondary Prevention Risk Interventions via Telemedicine and Tailored Patient Education (SPRITE): A randomized trial to improve post myocardial infarction management.

Journal Article Patient Educ Couns · September 2022 OBJECTIVE: We evaluated the impact of a low intensity web-based and intensive nurse-administered intervention to reduce systolic blood pressure (SBP) among patients with prior MI. METHODS: Secondary Prevention Risk Interventions via Telemedicine and Tailor ... Full text Open Access Link to item Cite

A Course in Biology and Communication Skills for Master of Biostatistics Students

Journal Article Journal of Curriculum and Teaching · January 1, 2022 We describe an innovative, semester-long course in biology and communication skills for master’s degree students in biostatistics. The primary goal of the course is to make the connection between biological science and statistics more explicit. The seconda ... Full text Cite

Preorientation Curriculum: An Approach for Preparing Students with Heterogenous Backgrounds for Training in a Master of Biostatistics Program

Journal Article Journal of Curriculum and Teaching · January 1, 2022 We describe an innovative preorientation curriculum (POC) for a Master of Biostatistics (MB) program. The goal of the POC is to fill critical skills gaps for students entering the MB program from heterogeneous backgrounds so they are prepared to engage in ... Full text Cite

Administrative Considerations Pertaining to the Use of Creative Methods of Student Assessment: A Theoretically Grounded Reflection from a Master of Biostatistics Program

Journal Article Journal of Curriculum and Teaching · January 1, 2022 Student evaluation is a key consideration for educational program administrators because program success depends on students' ability to demonstrate successful development of core competencies. Student evaluations must therefore be aligned with learning ob ... Full text Cite

Redesign of a First-Year Theory Course Sequence in Biostatistics

Journal Article Journal of Curriculum and Teaching · January 1, 2022 This communication describes the process and results of a curriculum review of a first-year sequence of courses in statistical inference within a Master of Biostatistics program. Our primary aim was to develop an innovative course in statistical theory tha ... Full text Cite

Impact of lifestyle Intervention on branched-chain amino acid catabolism and insulin sensitivity in adolescents with obesity.

Journal Article Endocrinol Diabetes Metab · July 2021 UNLABELLED: Insulin resistance in adolescents with obesity associates with a sex-dependent metabolic 'signature' comprising branched-chain amino acids (BCAAs), glutamate and C3/C5 acylcarnitines (C3/C5), implicating altered flux through BCAA catabolic path ... Full text Link to item Cite

The biomedical research pyramid: A model for the practice of biostatistics

Journal Article Journal of Curriculum and Teaching · February 1, 2021 Biostatisticians apply statistical methods to solve problems in the biological sciences. Successful practioners of biostatistics have advanced technical knowledge, are skilled communicators, and can seamlesslessly integrate with interdisciplinary scientifi ... Full text Cite

Methods for training collaborative biostatisticians.

Journal Article J Clin Transl Sci · August 4, 2020 The emphasis on team science in clinical and translational research increases the importance of collaborative biostatisticians (CBs) in healthcare. Adequate training and development of CBs ensure appropriate conduct of robust and meaningful research and, t ... Full text Link to item Cite

Criteria for rapidly incorporating online instruction into traditionally in-person programs: a case study

Journal Article Advances in Social Sciences Research Journal · May 3, 2020 Given the continuing uncertainty about the COCID-19 pandemic, we are planning for the possibility that, in the upcoming semester, some or all of the content of a Master of Biostatistics program will be delivered online.  In order to help make this ... Full text Open Access Cite

A multimodal international collaborative clinical research training program in China.

Journal Article Med Educ Online · December 2019 Background: There is a strong need to include training of research methods in training programs for physicians. International clinical research training programs (CRTP) that comprehensively introduce the methodology of clinical research and combined with p ... Full text Link to item Cite

Epidemiologic Trends in Clostridioides difficile Infections in a Regional Community Hospital Network.

Journal Article JAMA Netw Open · October 2, 2019 IMPORTANCE: Clostridioides difficile infection (CDI) remains a leading cause of health care facility-associated infection. A greater understanding of the regional epidemiologic profile of CDI could inform targeted prevention strategies. OBJECTIVES: To asse ... Full text Open Access Link to item Cite

A New Stress Test for Knee Joint Cartilage.

Journal Article Sci Rep · February 19, 2019 Cartilage metabolism-both the synthesis and breakdown of cartilage constituents and architecture-is influenced by its mechanical loading. Therefore, physical activity is often recommended to maintain cartilage health and to treat or slow the progression of ... Full text Link to item Cite

The Association Between Engagement and Weight Loss Through Personal Coaching and Cell Phone Interventions in Young Adults: Randomized Controlled Trial.

Journal Article JMIR Mhealth Uhealth · October 18, 2018 BACKGROUND: Understanding how engagement in mobile health (mHealth) weight loss interventions relates to weight change may help develop effective intervention strategies. OBJECTIVE: This study aims to examine the (1) patterns of participant engagement over ... Full text Open Access Link to item Cite

Indications for and outcomes of therapeutic plasma exchange after cardiac transplantation: A single center retrospective study.

Journal Article J Clin Apher · August 2018 INTRODUCTION: Limited data are available describing indications for and outcomes of therapeutic plasma exchange (TPE) in cardiac transplantation. METHODS: In a retrospective study of patients who underwent cardiac transplantation at Duke University Medical ... Full text Open Access Link to item Cite

The Association Between Engagement and Weight Loss Through Personal Coaching and Cell Phone Interventions in Young Adults: Randomized Controlled Trial (Preprint)

Journal Article · March 22, 2018 BACKGROUNDUnderstanding how engagement in mobile health (mHealth) weight loss interventions relates to weight change may help develop effective intervention strategies. ... Full text Open Access Cite

Outcome by Gender in the Veterans Health Administration Motivating Overweight/Obese Veterans Everywhere Weight Management Program.

Journal Article Journal of women's health (2002) · January 2018 BackgroundFew evaluations of the Veterans Health Administration Motivating Overweight/Obese Veterans Everywhere (MOVE!) weight management program have assessed 6-month weight change or factors associated with weight change by gender.Materials ... Full text Open Access Cite

Statistical competencies for medical research learners: What is fundamental?

Journal Article J Clin Transl Sci · June 2017 INTRODUCTION: It is increasingly essential for medical researchers to be literate in statistics, but the requisite degree of literacy is not the same for every statistical competency in translational research. Statistical competency can range from 'fundame ... Full text Open Access Link to item Cite

The Symptom Experience in Rectal Cancer Survivors.

Journal Article J Pain Symptom Manage · November 2016 CONTEXT: As the number of rectal cancer survivors grows, it is important to understand the symptom experience after treatment. Although data show that rectal cancer survivors experience a variety of symptoms after diagnosis, little has been done to study t ... Full text Link to item Cite

Mobile health devices: will patients actually use them?

Journal Article J Am Med Inform Assoc · May 2016 Although mobile health (mHealth) devices offer a unique opportunity to capture patient health data remotely, it is unclear whether patients will consistently use multiple devices simultaneously and/or if chronic disease affects adherence. Three healthy and ... Full text Open Access Link to item Cite

Adaptive intervention design in mobile health: Intervention design and development in the Cell Phone Intervention for You trial.

Journal Article Clin Trials · December 2015 BACKGROUND/AIMS: The obesity epidemic has spread to young adults, and obesity is a significant risk factor for cardiovascular disease. The prominence and increasing functionality of mobile phones may provide an opportunity to deliver longitudinal and scala ... Full text Open Access Link to item Cite

Impact of Smoking Cessation on Subsequent Pain Intensity Among Chronically Ill Veterans Enrolled in a Smoking Cessation Trial.

Journal Article J Pain Symptom Manage · December 2015 CONTEXT: Prior cross-sectional studies have reported greater pain intensity among persistent smokers compared with nonsmokers or former smokers; yet, few prospective studies have examined how smoking abstinence affects pain intensity. OBJECTIVES: To determ ... Full text Link to item Cite

Cell phone intervention for you (CITY): A randomized, controlled trial of behavioral weight loss intervention for young adults using mobile technology.

Journal Article Obesity (Silver Spring) · November 2015 OBJECTIVE: To determine the effect on weight of two mobile technology-based (mHealth) behavioral weight loss interventions in young adults. METHODS: Randomized, controlled comparative effectiveness trial in 18- to 35-year-olds with BMI ≥ 25 kg/m(2) (overwe ... Full text Open Access Link to item Cite

Physician Non-adherence to Colonoscopy Interval Guidelines in the Veterans Affairs Healthcare System.

Journal Article Gastroenterology · October 2015 BACKGROUND & AIMS: Colonoscopy can decrease colorectal cancer (CRC) mortality, although performing this procedure more frequently than recommended could increase costs and risks to patients. We aimed to determine rates and correlates of physician non-adher ... Full text Link to item Cite

Willingness of Patients to Use Computers for Health Communication and Monitoring Following Myocardial Infarction.

Journal Article Comput Inform Nurs · September 2015 We describe the computer use characteristics of 406 post-myocardial infarction (MI) patients and their willingness to engage online for health communication and monitoring. Most participants were computer users (n = 259; 63.8%) and half (n = 209; 51.5%) re ... Full text Open Access Link to item Cite

Error in Figure

Journal Article JAMA Internal Medicine · March 1, 2015 Full text Cite

Patient-provider communication, self-reported medication adherence, and race in a postmyocardial infarction population.

Journal Article Patient Prefer Adherence · 2015 OBJECTIVES: Our objectives were to: 1) describe patient-reported communication with their provider and explore differences in perceptions of racially diverse adherent versus nonadherent patients; and 2) examine whether the association between unanswered qu ... Full text Open Access Link to item Cite

Weight loss intervention for young adults using mobile technology: design and rationale of a randomized controlled trial - Cell Phone Intervention for You (CITY).

Journal Article Contemp Clin Trials · March 2014 BACKGROUND: The obesity epidemic has spread to young adults, leading to significant public health implications later in adulthood. Intervention in early adulthood may be an effective public health strategy for reducing the long-term health impact of the ep ... Full text Open Access Link to item Cite

Association between perceived life chaos and medication adherence in a postmyocardial infarction population.

Journal Article Circ Cardiovasc Qual Outcomes · November 2013 BACKGROUND: The benefits of medication adherence to control cardiovascular disease (CVD) are well defined, yet multiple studies have identified poor adherence. The influence of life chaos on medication adherence is unknown. Because this is a novel applicat ... Full text Open Access Link to item Cite

Validity of the Structured Clinical Interview for DSM-IV Among Veterans Seeking Treatment for Substance Use Disorders

Journal Article International Journal of Mental Health and Addiction · October 1, 2013 This paper examines the validity of the Structured Clinic Interview for DSM-IV (SCID) I and II in a sample of Veterans seeking treatment for substance use disorders (SUDs). Participants (N = 183) initially receiving residential or outpatient treatment for ... Full text Cite

Recruiting young adults into a weight loss trial: report of protocol development and recruitment results.

Journal Article Contemp Clin Trials · July 2013 Obesity has spread to all segments of the U.S. population. Young adults, aged 18-35 years, are rarely represented in clinical weight loss trials. We conducted a qualitative study to identify factors that may facilitate recruitment of young adults into a we ... Full text Open Access Link to item Cite

Variability in resource use: diagnosing colorectal cancer.

Journal Article Am J Manag Care · May 2013 OBJECTIVES: Efficient resource use is relevant in all healthcare systems. Although colorectal cancer is common, little has been published regarding the utilization of clinical resources in diagnosis. STUDY DESIGN: The primary aim was to evaluate the patter ... Link to item Cite

Contracting, prompting and reinforcing substance use disorder continuing care.

Journal Article J Subst Abuse Treat · April 2013 The contracting, prompting and reinforcing (CPR) aftercare intervention has improved treatment adherence and outcomes in a number of clinical trials. In multisite randomized clinical trial 92 graduates of two intensive substance use disorder programs who r ... Full text Link to item Cite

Chemotherapy use and patient treatment preferences in advanced colorectal cancer: a prospective cohort study.

Journal Article Cancer · February 15, 2013 BACKGROUND: The objective of this study was to determine how patient preferences guide the course of palliative chemotherapy for advanced colorectal cancer. METHODS: Eligible patients with metastatic colorectal cancer (mCRC) were enrolled nationwide in a p ... Full text Link to item Cite

Dietary saturated fat intake is negatively associated with weight maintenance among the PREMIER participants.

Journal Article Obesity (Silver Spring) · March 2012 Research finding on the composition of macronutrient intakes on body weight has not been consistent. Furthermore, little research has examined the impact of subcomponents of macronutrients such as saturated fat or plant protein on body weight. The purpose ... Full text Link to item Cite

Correlates of expected positive and negative support for smoking cessation among a sample of chronically ill veterans.

Journal Article Addict Behav · January 2012 OBJECTIVE: To examine demographic, relationship, and smoking history factors related to expected positive and negative support for quitting smoking among chronically ill veterans. METHODS: Data for this report comes from baseline data from a randomized con ... Full text Link to item Cite

Early dissemination of bevacizumab for advanced colorectal cancer: a prospective cohort study.

Journal Article BMC Cancer · August 16, 2011 BACKGROUND: We describe early dissemination patterns for first-line bevacizumab given for metastatic colorectal cancer treatment. METHODS: We analyzed patient surveys and medical records for a population-based cohort with metastatic colorectal cancer treat ... Full text Link to item Cite

Secondary prevention risk interventions via telemedicine and tailored patient education (SPRITE): a randomized trial to improve postmyocardial infarction management.

Journal Article Circ Cardiovasc Qual Outcomes · March 2011 BACKGROUND: Secondary prevention by risk factor modification improves patient outcomes, yet it is often not achieved in clinical practice. Reasons for failure stem from challenges of prioritizing risk factor reduction and engaging patients in changing thei ... Full text Open Access Link to item Cite

The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index.

Journal Article J Clin Endocrinol Metab · January 2011 CONTEXT: Insulin sensitivity is higher in patients with Prader-Willi syndrome (PWS) than in body mass index-matched obese controls (OCs). Factors contributing to the heightened insulin sensitivity of PWS remain obscure. We compared the fasting levels of va ... Full text Link to item Cite

Quality of nonmetastatic colorectal cancer care in the Department of Veterans Affairs.

Journal Article J Clin Oncol · July 1, 2010 PURPOSE: The Veterans Affairs (VA) healthcare system treats approximately 3% of patients with cancer in the United States each year. We measured the quality of nonmetastatic colorectal cancer (CRC) care in VA as indicated by concordance with National Compr ... Full text Link to item Cite

Determinants of medical system delay in the diagnosis of colorectal cancer within the Veteran Affairs Health System.

Journal Article Dig Dis Sci · May 2010 Featured Publication BACKGROUND AND AIMS: The goals of this study are to evaluate determinants of the time in the medical system until a colorectal cancer diagnosis and to explore characteristics associated with stage at diagnosis. METHODS: We examined medical records and surv ... Full text Link to item Cite

A randomized trial of a low-carbohydrate diet vs orlistat plus a low-fat diet for weight loss.

Journal Article Arch Intern Med · January 25, 2010 Featured Publication BACKGROUND: Two potent weight loss therapies, a low-carbohydrate, ketogenic diet (LCKD) and orlistat therapy combined with a low-fat diet (O + LFD), are available to the public but, to our knowledge, have never been compared. METHODS: Overweight or obese o ... Full text Link to item Cite

Comparison of medicine resident diabetes care between Veterans Affairs and academic health care systems.

Journal Article J Gen Intern Med · August 2009 Featured Publication BACKGROUND: Although others have reported national disparities in the quality of diabetes care between the Veterans Affairs (VA) and private health care delivery systems, it is not known whether these differences persist among internal medicine resident pr ... Full text Link to item Cite

Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.

Journal Article J Natl Med Assoc · July 2009 Featured Publication BACKGROUND: Individual variation in circulating insulinlike growth factor-1 (IGF1) and its major binding protein, insulinlike growth factor binding protein-3 (IGFBP3), have been etiologically linked to several chronic diseases, including some cancers. Fact ... Full text Link to item Cite

Factors associated with chemotherapy receipt and intensity for stage IV colorectal cancer (CRC): A multihealth system, population-based study.

Journal Article J Clin Oncol · May 20, 2009 6519 Background: Little is known about chemotherapy practice patterns for patients with stage IV CRC. METHODS: Cancer Outcomes Research & Surveillance Consortium (CanCORS) is a prospective cohort study including patients with incident CRC sampled from a se ... Link to item Cite

Cost minimization analysis of a store-and-forward teledermatology consult system.

Journal Article Telemed J E Health · March 2009 Featured Publication The aim of this study was to perform a cost minimization analysis of store-and-forward teledermatology compared to a conventional dermatology referral process (usual care). In a Department of Defense (DoD) setting, subjects were randomized to either a tele ... Full text Link to item Cite

Clinical aspects of ALS in Gulf War veterans.

Journal Article Amyotroph Lateral Scler · February 2009 Featured Publication The increased incidence of ALS in military veterans of the first Persian Gulf War raised speculation that they may have a 'Persian Gulf' variant of ALS with atypical clinical features. Medical records of military veterans with ALS, previously identified in ... Full text Link to item Cite

Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development.

Journal Article Clin Endocrinol (Oxf) · December 2008 Featured Publication BACKGROUND: Prader-Willi syndrome (PWS) is associated with failure to thrive in infancy and progressive hyperphagia and obesity in childhood. This progressive weight gain is associated with hyperghrelinaemia and increased insulin sensitivity. The role of g ... Full text Link to item Cite

Comorbidity, age, race and stage at diagnosis in colorectal cancer: a retrospective, parallel analysis of two health systems.

Journal Article BMC Cancer · November 25, 2008 Featured Publication BACKGROUND: Stage at diagnosis plays a significant role in colorectal cancer (CRC) survival. Understanding which factors contribute to a more advanced stage at diagnosis is vital to improving overall survival. Comorbidity, race, and age are known to impact ... Full text Open Access Link to item Cite

Comorbidity, age, race and stage at diagnosis in colorectal cancer: A retrospective, parallel analysis of two health systems

Journal Article BMC Cancer · November 25, 2008 Background: Stage at diagnosis plays a significant role in colorectal cancer (CRC) survival. Understanding which factors contribute to a more advanced stage at diagnosis is vital to improving overall survival. Comorbidity, race, and age are known to impact ... Full text Cite

Promoting continuing care adherence among substance abusers with co-occurring psychiatric disorders following residential treatment.

Journal Article Addict Behav · September 2008 Featured Publication Epidemiological data from treatment and community samples of individuals with substance use disorders indicate that the rates of co-occurring psychiatric disorders are high and that these disorders are associated with poor treatment adherence and outcomes. ... Full text Link to item Cite

Clinical aspects of ALS in Gulf War Veterans.

Journal Article Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases · September 2008 The increased incidence of ALS in military veterans of the first Persian Gulf War raised speculation that they may have a 'Persian Gulf' variant of ALS with atypical clinical features. Medical records of military veterans with ALS, previously identified in ... Cite

Amyotrophic lateral sclerosis among 1991 Gulf War veterans: evidence for a time-limited outbreak.

Journal Article Neuroepidemiology · 2008 Featured Publication BACKGROUND: In follow-up to recent reports of an elevated risk of amyotrophic lateral sclerosis (ALS) among 1991 Gulf War veterans, we analyzed the distribution of disease onset times to determine whether the excess risk was time limited. METHODS: This sec ... Full text Link to item Cite

Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones.

Journal Article Clin Endocrinol (Oxf) · December 2007 Featured Publication OBJECTIVE: Prader-Willi syndrome (PWS) is a genetic syndrome characterized by relative hypoinsulinaemia and normal or increased insulin sensitivity despite profound obesity. We hypothesized that this increased insulin sensitivity is mediated by increased l ... Full text Link to item Cite

Contracting, prompting, and reinforcing substance use disorder continuing care: a randomized clinical trial.

Journal Article Psychol Addict Behav · September 2007 Featured Publication Although continuing care is strongly related to positive treatment outcomes for substance use disorder (SUD), participation rates are low and few effective interventions are available. In a randomized clinical trial with 150 participants (97% men), 75 grad ... Full text Link to item Cite

Convergent validity of the Timeline Followback for persons with comorbid psychiatric disorders engaged in residential substance use treatment.

Journal Article Addict Behav · August 2007 Featured Publication This study examined the convergent validity of the Timeline Followback (TLFB) for individuals with comorbid (Axis I and/or Axis II) psychiatric disorders in a sample of persons (N=150) engaged in residential treatment for substance use disorders (SUDs). Ap ... Full text Link to item Cite

Grade-specific prostate cancer associations of IGF1 (CA)19 repeats and IGFBP3-202A/C in blacks and whites.

Journal Article J Natl Med Assoc · July 2007 Featured Publication Carrying the cytosine-adenosine (CA)19 repeat polymorphism in insulin-like growth factor-1 (IGF1) is associated with lower serum proteins and decreased prostate cancer risk. Carrying the -202A/C genotype in insulin-like growth factor binding protein-3 (IGF ... Link to item Cite

Behind closed doors: management of patient expectations in primary care practices.

Journal Article Arch Intern Med · March 12, 2007 Featured Publication BACKGROUND: Managed care restrictions on resource use may affect communication between patients and health care professionals. METHODS: To characterize negotiations between primary care physicians and patients with expectations for new medications, tests, ... Full text Link to item Cite

Store-and-forward teledermatology results in similar clinical outcomes to conventional clinic-based care.

Journal Article J Telemed Telecare · 2007 Featured Publication We compared the clinical outcomes after store-and-forward teledermatology with those following conventional clinic-based consultation. Subjects were randomized to either usual care (a conventional clinic-based dermatology appointment) or a store-and-forwar ... Full text Link to item Cite

Physician-diagnosed depression as a correlate of hospitalizations in patients receiving long-term hemodialysis.

Journal Article Am J Kidney Dis · October 2005 Featured Publication BACKGROUND: Hospital admissions consume a large proportion of costs for the end-stage renal disease (ESRD) program in the United States. We investigated whether a physician diagnosis of depression increases the risk for hospitalization or death in patients ... Full text Link to item Cite

Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress.

Journal Article Environ Health Perspect · August 2005 Featured Publication Health effects associated with particulate matter (PM) show seasonal variations. We hypothesized that these heterogeneous effects may be attributed partly to the differences in the elemental composition of PM. Normal human bronchial epithelial (NHBE) cells ... Full text Open Access Link to item Cite

Prostate cancer: a significant risk factor for late-life suicide.

Journal Article Am J Geriatr Psychiatry · March 2005 Featured Publication OBJECTIVE: The authors sought to determine the incidence of suicide and its relevant correlates among men with prostate cancer. METHODS: This was a population-based, retrospective cohort review of men age 65 and older, residing in South Florida between 198 ... Full text Link to item Cite

IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2005 Featured Publication We investigated the relationship between the insulin-like growth factor-1 (IGF1) cytosine-adenine repeat (CA)(19) polymorphism located upstream of the gene's transcription start site, the insulin-like growth factor binding protein-3 (IGFBP3) -202 A/C promo ... Full text Link to item Cite

Initiation and discontinuation of hormone therapy for menopausal symptoms: results from a community sample.

Journal Article J Behav Med · February 2005 Featured Publication Factors related to initiation and discontinuation of hormonal therapy (HT) for treatment of menopausal symptoms were examined in a community sample of 533 peri/postmenopausal women aged 45-54 by telephone three times. Over 40 variables including: sociodemo ... Full text Link to item Cite

Estimating the occurrence of amyotrophic lateral sclerosis among Gulf War (1990-1991) veterans using capture-recapture methods.

Journal Article Neuroepidemiology · 2005 Featured Publication OBJECTIVE: Using data from a recent report that indicated a 2-fold higher risk of amyotrophic lateral sclerosis (ALS) among veterans of the 1991 Gulf War, we applied capture-recapture methodology to estimate possible under-ascertainment of ALS cases among ... Full text Link to item Cite

Do unmet expectations for specific tests, referrals, and new medications reduce patients' satisfaction?

Journal Article J Gen Intern Med · November 2004 Featured Publication BACKGROUND: Patient-centered care requires clinicians to recognize and act on patients' expectations. However, relatively little is known about the specific expectations patients bring to the primary care visit. OBJECTIVE: To describe the nature and preval ... Full text Link to item Cite

Racial/ethnic variations in non-steroidal anti-inflammatory drug (NSAID) use among patients with osteoarthritis.

Journal Article Pharmacoepidemiol Drug Saf · October 2004 Featured Publication PURPOSE: Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed drugs for the treatment of osteoarthritis (OA). While there are documented racial differences in the use of opioid analgesics, little is known about racial differences ... Full text Link to item Cite

Patient risk perceptions for carotid endarterectomy: which patients are strongly averse to surgery?

Journal Article J Vasc Surg · July 2004 Featured Publication BACKGROUND AND PURPOSE: Patient risk perception for surgery may be central to their willingness to undergo surgery. This study examined potential factors associated with patient aversion of surgery. METHODS: This is a secondary data analysis of a prospecti ... Full text Link to item Cite

The effect of the PREMIER interventions on insulin sensitivity.

Journal Article Diabetes Care · February 2004 Featured Publication OBJECTIVE: This ancillary study of PREMIER sought to determine the effects on insulin sensitivity of a comprehensive behavioral intervention for hypertension with and without the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. RESEARCH DESI ... Full text Link to item Cite

Who doesn't receive carotid endarterectomy when appropriate?

Journal Article J Vasc Surg · January 2004 Featured Publication OBJECTIVE: The purpose of this study was to identify clinical and nonclinical factors associated with failure to perform carotid endarterectomy (CEA) in patients with clinically appropriate indications. We analyzed data from a prospective cohort study perf ... Full text Link to item Cite

Patient and clinician satisfaction with a store-and-forward teledermatology consult system.

Journal Article Telemed J E Health · 2004 Featured Publication The aim of this study was to assess satisfaction with and acceptance of a store and forward teledermatology consult system among patients, referring primary-care clinicians, and consultant dermatologists. As part of a randomized clinical trial that compare ... Full text Link to item Cite

Congestive heart failure patients' perceptions of quality of life: the integration of physical and psychosocial factors.

Journal Article Aging Ment Health · January 2004 Featured Publication Congestive heart failure (CHF) lowers survival and worsens the quality of life (QOL) of over four million older Americans. Both clinicians and standardized instruments used to assess the QOL of patients with CHF focus primarily on physical symptoms rather ... Full text Link to item Cite

Nonsteroidal antiinflammatory drug use among patients with GI bleeding.

Journal Article Ann Pharmacother · 2004 Featured Publication BACKGROUND: Previous studies have suggested that recommended gastroprotective strategies such as gastroprotective agents (GPAs) and cyclooxygenase (COX) 2 inhibitors may be underutilized among individuals at risk for nonsteroidal antiinflammatory drug (NSA ... Full text Link to item Cite

Re: Mortality and follow-up colonoscopy after colorectal cancer

Journal Article AMERICAN JOURNAL OF GASTROENTEROLOGY · December 1, 2003 Link to item Cite

Rheumatology patients' use of complementary therapies: results from a one-year longitudinal study.

Journal Article Arthritis Rheum · October 15, 2003 Featured Publication OBJECTIVE: To examine the natural history of complementary and alternative medicine (CAM) use and its impact on outcomes within a cohort of rheumatology patients. METHODS: Consecutive patients were recruited from 3 university and 3 private rheumatology pra ... Full text Link to item Cite

Ultrasound assessment of the fetal middle cerebral artery peak systolic velocity: A comparison of the near-field versus far-field vessel.

Journal Article Am J Obstet Gynecol · October 2003 Featured Publication OBJECTIVE: Doppler assessment of the fetal middle cerebral artery peak systolic velocity may obviate the need for more invasive procedures in the alloimmunized patient. The purpose of this study was to compare middle cerebral artery peak systolic velocity ... Full text Link to item Cite

Racial differences in health care utilization among patients with osteoarthritis.

Journal Article J Rheumatol · October 2003 Featured Publication OBJECTIVE: Research has identified racial variations in certain aspects of osteoarthritis (OA) related medical care. We compared health services utilization between African American and white veteran outpatients with OA. METHODS: Subjects were 1612 white a ... Link to item Cite

Occurrence of amyotrophic lateral sclerosis among Gulf War veterans.

Journal Article Neurology · September 23, 2003 Featured Publication BACKGROUND: In response to Gulf War veterans' concerns of high rates of ALS, this investigation sought to determine if Gulf War veterans have an elevated rate of ALS. METHODS: A nationwide epidemiologic case ascertainment study design was used to ascertain ... Full text Link to item Cite

Potential role of increased iron stores in diabetes.

Journal Article Am J Med Sci · June 2003 Featured Publication Diabetes mellitus (DM) is an important risk factor for the development of cardiovascular disease. Extensive clinical, epidemiologic, and basic studies suggest that excessive tissue iron stores may contribute to the occurrence and complications of DM. Secon ... Full text Link to item Cite

The role of soluble components in ambient fine particles-induced changes in human lungs and blood.

Journal Article Inhal Toxicol · April 11, 2003 Featured Publication Normal individuals developed pulmonary neutrophilic inflammation and increased blood fibrinogen following inhalation of concentrated ambient particles (CAPS). In this study, we sought to determine how soluble components in CAPS contributed to these changes ... Full text Link to item Cite

Mortality and follow-up colonoscopy after colorectal cancer.

Journal Article Am J Gastroenterol · April 2003 Featured Publication OBJECTIVE: There have been no studies that demonstrate surveillance colonoscopy decreases mortality in patients with a history of colorectal cancer. The purpose of this study was to compare the mortality of patients with colorectal cancer who received at l ... Full text Link to item Cite

An economic analysis of a store and forward teledermatology consult system.

Journal Article Telemed J E Health · 2003 Featured Publication Our objective was to assess the economic impact of store-and-forward teledermatology in a United States Department of Veterans Affairs (VA) health care setting. Patients being referred to the Dermatology Consult Service from the Primary Care Clinics at the ... Full text Link to item Cite

Medical service utilization by veterans seeking help for posttraumatic stress disorder.

Journal Article Am J Psychiatry · December 2002 Featured Publication OBJECTIVE: Posttraumatic stress disorder (PTSD) has been associated with higher rates of health complaints and medical conditions diagnosed by physicians, yet research examining the relationship between PTSD and health care utilization has been limited. Th ... Full text Link to item Cite

Mortality and follow-up colonoscopy for colorectal cancer

Journal Article The American Journal of Gastroenterology · September 2002 Full text Cite

Racial variations in postoperative outcomes of carotid endarterectomy: evidence from the Veterans Affairs National Surgical Quality Improvement Program.

Journal Article Med Care · January 2002 Featured Publication CONTEXT: Black patients and Hispanic patients receive carotid endarterectomy (CEA) at lower rates than white patients. It is unclear whether worse surgical outcomes are influencing clinical decision-making regarding use of the operation among minority grou ... Link to item Cite

Teledermatology's impact on time to intervention among referrals to a dermatology consult service.

Journal Article Telemed J E Health · 2002 Featured Publication The aim of this study was to determine if a teledermatology consult system, using store-and-forward digital imaging technology, results in patients achieving a shorter time from referral date to date of initial definitive intervention when compared to a tr ... Full text Link to item Cite

Racial differences in physician recommendation of hormone replacement therapy.

Journal Article Prev Med · December 2001 Featured Publication PURPOSE: Previous studies have suggested that black women may be less likely than white women to be offered and to take hormone replacement therapy (HRT). Thus, race and other factors associated with physician recommendation of HRT that may influence women ... Full text Link to item Cite

Preparing for the end of life: preferences of patients, families, physicians, and other care providers.

Journal Article J Pain Symptom Manage · September 2001 Featured Publication To examine patients', families', and health care providers' preferences regarding preparation for the end of life, attributes of preparation were generated in qualitative focus group discussions and subsequently tested for generalizability in a quantitativ ... Full text Link to item Cite

The Nature and Prevalence of Patient Expectations in a VA General Medicine Clinic

Journal Article Journal of General Internal Medicine · October 2000 Full text Cite

Absence of detectable pharmacological effects after oral administration of isoxsuprine.

Journal Article Equine Vet J · July 1998 Featured Publication Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To define the scope a ... Full text Link to item Cite