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Tiffany N Hilton

Associate Professor in Orthopaedic Surgery
Orthopaedic Surgery, Physical Therapy
311 Trent Drive, Durham, NC 27710

Selected Publications


Validity of Visual Assessment of Sit to Stand After Hip Fracture.

Journal Article J Geriatr Phys Ther · 2020 BACKGROUND AND PURPOSE: When treating older adults post-hip fracture, physical therapists routinely assess the sit-to-stand (STS) task using observational analysis. Studies have demonstrated that significant movement asymmetries in ground reaction force pr ... Full text Link to item Cite

Enhancing physical function in HIV-infected older adults: A randomized controlled clinical trial.

Journal Article Health Psychol · June 2016 OBJECTIVE: HIV-infected older adults (HOA) are at risk of functional decline. Interventions promoting physical activity that can attenuate functional decline and are easily translated into the HOA community are of high priority. We conducted a randomized, ... Full text Link to item Cite

Does emotional intelligence influence success during medical school admissions and program matriculation?: a systematic review.

Journal Article J Educ Eval Health Prof · 2016 PURPOSE: It aimed at determining whether emotional intelligence is a predictor for success in a medical school program and whether the emotional intelligence construct correlated with other markers for admission into medical school. METHODS: Three database ... Full text Link to item Cite

Physical Therapy in Cardiovascular and Pulmonary Conditions

Chapter · January 1, 2016 This comprehensive text offers an insightful and thorough overview of both the profession and the practice of physical therapy, including the latest topics and trends surrounding the industry. ... Cite

Weight-bearing asymmetry in individuals post-hip fracture during the sit to stand task.

Journal Article Clin Biomech (Bristol, Avon) · January 2015 BACKGROUND: Individuals post hip fracture decrease force on the involved limb during sit to stand tasks, creating an asymmetry in vertical ground reaction force. Joint specific differences that underlie asymmetry of the vertical ground reaction force are u ... Full text Link to item Cite

Functional Limitations and Adipokines in HIV-Infected Older Adults.

Journal Article The Journal of frailty & aging · 2015 Cite

Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults.

Journal Article Osteoporos Int · February 2014 UNLABELLED: We studied the relationships among strength, muscle mass, and bone mineral density (BMD) with lifestyle change. Lifestyle therapy consisted of exercise, diet, and diet plus exercise. Diet was by caloric restriction to induce and maintain a weig ... Full text Link to item Cite

A new frailty syndrome: central obesity and frailty in older adults with the human immunodeficiency virus.

Journal Article J Am Geriatr Soc · March 2012 OBJECTIVES: To evaluate the relationships between body composition and physical frailty in community-dwelling older adults with the human immunodeficiency virus (HIV) (HOA). DESIGN: Cross-sectional. SETTING: Academic hospital-based infectious disease clini ... Full text Link to item Cite

Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones.

Journal Article J Bone Miner Res · December 2011 Weight loss therapy to improve health in obese older adults is controversial because it causes further bone loss. Therefore, it is recommended that weight loss therapy should include an intervention such as exercise training (ET) to minimize bone loss. The ... Full text Link to item Cite

Weight loss, exercise, or both and physical function in obese older adults

Journal Article Obstetrical and Gynecological Survey · August 1, 2011 Full text Cite

Physical Therapy in Cardiovascular and Pulmonary Conditions

Chapter · April 2011 Providing an overview of the profession and practice of physical therapy, this text presents an excellent introduction to any program of study in physical therapy. ... Cite

Weight loss, exercise, or both and physical function in obese older adults.

Journal Article N Engl J Med · March 31, 2011 BACKGROUND: Obesity exacerbates the age-related decline in physical function and causes frailty in older adults; however, the appropriate treatment for obese older adults is controversial. METHODS: In this 1-year, randomized, controlled trial, we evaluated ... Full text Link to item Cite

Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults.

Journal Article Obesity (Silver Spring) · December 2009 Both obesity and aging increase intrahepatic fat (IHF) content, which leads to nonalcoholic fatty liver disease (NAFLD) and metabolic abnormalities such as insulin resistance. We evaluated the effects of diet and diet in conjunction with exercise on IHF co ... Full text Link to item Cite

Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function.

Journal Article Phys Ther · November 2008 BACKGROUND AND PURPOSE: The primary purpose of this study was to report differences in calf intermuscular adipose tissue (IMAT), muscle strength (peak torque), power, and physical function in individuals with obesity, diabetes mellitus (DM), and peripheral ... Full text Link to item Cite

Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults.

Journal Article Med Sci Sports Exerc · July 2008 PURPOSE: To evaluate the effect of adding exercise to a hypocaloric diet on changes in appendicular lean mass and strength in frail obese older adults undergoing voluntary weight loss. METHODS: Thirty frail older (age, 70 +/- 5 yr) obese (body mass index, ... Full text Link to item Cite

Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women.

Journal Article PLoS One · March 26, 2008 Women have less muscle than men but lose it more slowly during aging. To discover potential underlying mechanism(s) for this we evaluated the muscle protein synthesis process in postabsorptive conditions and during feeding in twenty-nine 65-80 year old men ... Full text Link to item Cite

Alterations in inorganic phosphate in mouse hindlimb muscles during limb disuse.

Journal Article NMR Biomed · February 2008 Muscle disuse induces a wide array of structural, biochemical, and neural adaptations in skeletal muscle, which can affect its function. We recently demonstrated in patients with an orthopedic injury that cast immobilization alters the resting P(i) content ... Full text Link to item Cite

Validity of Visual Assessment of Sit to Stand After Hip Fracture.

Journal Article J Geriatr Phys Ther · 2020 BACKGROUND AND PURPOSE: When treating older adults post-hip fracture, physical therapists routinely assess the sit-to-stand (STS) task using observational analysis. Studies have demonstrated that significant movement asymmetries in ground reaction force pr ... Full text Link to item Cite

Enhancing physical function in HIV-infected older adults: A randomized controlled clinical trial.

Journal Article Health Psychol · June 2016 OBJECTIVE: HIV-infected older adults (HOA) are at risk of functional decline. Interventions promoting physical activity that can attenuate functional decline and are easily translated into the HOA community are of high priority. We conducted a randomized, ... Full text Link to item Cite

Does emotional intelligence influence success during medical school admissions and program matriculation?: a systematic review.

Journal Article J Educ Eval Health Prof · 2016 PURPOSE: It aimed at determining whether emotional intelligence is a predictor for success in a medical school program and whether the emotional intelligence construct correlated with other markers for admission into medical school. METHODS: Three database ... Full text Link to item Cite

Physical Therapy in Cardiovascular and Pulmonary Conditions

Chapter · January 1, 2016 This comprehensive text offers an insightful and thorough overview of both the profession and the practice of physical therapy, including the latest topics and trends surrounding the industry. ... Cite

Weight-bearing asymmetry in individuals post-hip fracture during the sit to stand task.

Journal Article Clin Biomech (Bristol, Avon) · January 2015 BACKGROUND: Individuals post hip fracture decrease force on the involved limb during sit to stand tasks, creating an asymmetry in vertical ground reaction force. Joint specific differences that underlie asymmetry of the vertical ground reaction force are u ... Full text Link to item Cite

Functional Limitations and Adipokines in HIV-Infected Older Adults.

Journal Article The Journal of frailty & aging · 2015 Cite

Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults.

Journal Article Osteoporos Int · February 2014 UNLABELLED: We studied the relationships among strength, muscle mass, and bone mineral density (BMD) with lifestyle change. Lifestyle therapy consisted of exercise, diet, and diet plus exercise. Diet was by caloric restriction to induce and maintain a weig ... Full text Link to item Cite

A new frailty syndrome: central obesity and frailty in older adults with the human immunodeficiency virus.

Journal Article J Am Geriatr Soc · March 2012 OBJECTIVES: To evaluate the relationships between body composition and physical frailty in community-dwelling older adults with the human immunodeficiency virus (HIV) (HOA). DESIGN: Cross-sectional. SETTING: Academic hospital-based infectious disease clini ... Full text Link to item Cite

Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones.

Journal Article J Bone Miner Res · December 2011 Weight loss therapy to improve health in obese older adults is controversial because it causes further bone loss. Therefore, it is recommended that weight loss therapy should include an intervention such as exercise training (ET) to minimize bone loss. The ... Full text Link to item Cite

Weight loss, exercise, or both and physical function in obese older adults

Journal Article Obstetrical and Gynecological Survey · August 1, 2011 Full text Cite

Physical Therapy in Cardiovascular and Pulmonary Conditions

Chapter · April 2011 Providing an overview of the profession and practice of physical therapy, this text presents an excellent introduction to any program of study in physical therapy. ... Cite

Weight loss, exercise, or both and physical function in obese older adults.

Journal Article N Engl J Med · March 31, 2011 BACKGROUND: Obesity exacerbates the age-related decline in physical function and causes frailty in older adults; however, the appropriate treatment for obese older adults is controversial. METHODS: In this 1-year, randomized, controlled trial, we evaluated ... Full text Link to item Cite

Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults.

Journal Article Obesity (Silver Spring) · December 2009 Both obesity and aging increase intrahepatic fat (IHF) content, which leads to nonalcoholic fatty liver disease (NAFLD) and metabolic abnormalities such as insulin resistance. We evaluated the effects of diet and diet in conjunction with exercise on IHF co ... Full text Link to item Cite

Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function.

Journal Article Phys Ther · November 2008 BACKGROUND AND PURPOSE: The primary purpose of this study was to report differences in calf intermuscular adipose tissue (IMAT), muscle strength (peak torque), power, and physical function in individuals with obesity, diabetes mellitus (DM), and peripheral ... Full text Link to item Cite

Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults.

Journal Article Med Sci Sports Exerc · July 2008 PURPOSE: To evaluate the effect of adding exercise to a hypocaloric diet on changes in appendicular lean mass and strength in frail obese older adults undergoing voluntary weight loss. METHODS: Thirty frail older (age, 70 +/- 5 yr) obese (body mass index, ... Full text Link to item Cite

Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women.

Journal Article PLoS One · March 26, 2008 Women have less muscle than men but lose it more slowly during aging. To discover potential underlying mechanism(s) for this we evaluated the muscle protein synthesis process in postabsorptive conditions and during feeding in twenty-nine 65-80 year old men ... Full text Link to item Cite

Alterations in inorganic phosphate in mouse hindlimb muscles during limb disuse.

Journal Article NMR Biomed · February 2008 Muscle disuse induces a wide array of structural, biochemical, and neural adaptations in skeletal muscle, which can affect its function. We recently demonstrated in patients with an orthopedic injury that cast immobilization alters the resting P(i) content ... Full text Link to item Cite

A model of muscle atrophy using cast immobilization in mice.

Journal Article Muscle Nerve · November 2005 We describe a new cast-immobilization protocol to induce muscle atrophy in the lower hindlimb muscles of mice. Bilateral cast immobilization for 2 weeks in a shortened position resulted in a significant loss of muscle size and strength in the soleus and ex ... Full text Link to item Cite

Noninvasive monitoring of muscle damage during reloading following limb disuse.

Journal Article Muscle Nerve · November 2005 Cast immobilization causes skeletal muscle disuse atrophy and an increased susceptibility to muscle damage. The objective of this study was to explore the utility of noninvasive magnetic resonance (MR) imaging to monitor muscle damage in the lower hindlimb ... Full text Link to item Cite

Muscle adaptations with immobilization and rehabilitation after ankle fracture.

Journal Article Med Sci Sports Exerc · October 2004 UNLABELLED: INTRODUCTION/ PURPOSE: The widespread occurrence of muscular atrophy during immobilization and its reversal presents an important challenge to rehabilitation medicine. We used 3D-magnetic resonance imaging (MRI) in patients with surgically-stab ... Full text Link to item Cite