Scholars@Duke
Anthony Thomas Dren

Anthony Thomas Dren

Consulting Professor in the School of Nursing
School of Nursing
tony.dren@duke.edu
Box 3322 Med Ctr, Durham, NC 27710
Room 3214 Ipe Building, Duke University Sch of Nursing, Durham, NC 27710

Selected Publications

Bidirectional interaction of valproate and lamotrigine in healthy subjects.

Journal Article Clinical pharmacology and therapeutics · August 1996 ObjectiveTo evaluate the steady-state pharmacokinetics of lamotrigine and valproate at three dosing levels of lamotrigine in normal volunteers receiving steady-state therapeutic doses of valproate.MethodsThis was an open-label, randomized ... Full text Cite

Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. U.S. Lamotrigine Protocol 0.5 Clinical Trial Group.

Journal Article Neurology · November 1993 We evaluated the efficacy and safety of lamotrigine (300 and 500 mg/day) as add-on therapy in a multicenter, randomized, double-blind, parallel-group, placebo-controlled study of 216 patients with refractory partial seizures. During 6 months of treatment, ... Full text Link to item Cite

Does sigma receptor antagonism predict clinical antipsychotic efficacy?

Journal Article Psychopharmacology bulletin · January 1991 The psychotogenic actions of sigma receptor agonists, such as pentazocine, have led to the hypothesis that sigma receptor antagonists may be putative antipsychotic agents. In this study, BW234U, a selective but relatively weak sigma receptor antagonist was ... Cite

INTRAVENOUS ANESTHETIC ACTIVITY OF BICYCLIC KETALS STRUCTURALLY RELATED TO KETAMINE AND ETOXADROL

Journal Article PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR · September 1, 1987 Link to item Cite

Case report: The case of the disappearing white blood cells.

Journal Article J Clin Res Drug Dev · 1987 Cite

BW234U: a non-dopamine receptor blocking antipsychotic drug without extrapyramidal effects?

Journal Article Drug Development Research · 1985 Based on studies in animals and in healthy human volunteers, it was predicted that the carbazole compound BW234U would have antipsychotic effects in patients without producing concomitant extrapyramidal effects. The compound was administered to 22 inpatien ... Cite

Open-label evaluation of the novel antipsychotic compound BW234U in chronic schizophrenics.

Journal Article Drug Development Research · 1985 In a 28-day open label study, 15 inpatients with chronic schizophrenia in relapse were treated with BW234U. Approximately half of the patients showed marked improvement. Four patients showed no change and three dropped out. Thought disturbance improved mar ... Full text Cite

New azacannabinoids highly active in the central nervous system.

Journal Article Journal of medicinal chemistry · February 1983 Full text Cite

Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range study

Journal Article Drug Development Research · January 1, 1983 In a 28‐day, dose‐range study, 11 chronic schizophrenic inpatients newly admitted to the hospital with acute exacerbations were administered a new antipsychotic, BW 234U, in daily doses ranging from 100 to 400 mg/day on a fixed/flexible schedule to determi ... Full text Cite

The first clinical study of BW-234U in schizophrenia.

Journal Article Psychopharmacol Bull · October 1982 Link to item Cite

N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain.

Journal Article The Journal of pharmacy and pharmacology · February 1979 N-o-Methoxyphenylpiperazine (MPP) is a moderately effective in vivo blocker of dopaminergic receptors. Its ability to increase the concentration of rat brain homovanillic acid (HVA) and the resulting time course for HVA were similar to the actions of cloza ... Full text Cite

Local anesthetic activity and acute toxicity of N-substituted 1,2,3,4-tetrahydro-1- and 2-naphthylamines.

Journal Article Journal of pharmaceutical sciences · June 1978 Seven N-substituted 1,2,3,4-tetrahydro-1- and three 2-naphthylamines were prepared and tested for local anesthetic activity in the rabbit corneal reflex test and the mouse sciatic nerve block test. At 0.1 and 1%, three 1-alkylamino compounds had durations ... Full text Cite

3-Halo-5,7-dimethylpyrazolo [1,5-a]pyrimidines, a nonbenzodiazepinoid class of antianxiety agents devoid of potentiation of central nervous system depressant effects of ethanol or barbiturates.

Journal Article Journal of medicinal chemistry · March 1977 Forty derivatives (1-40) of pyrazolo[1,5-a]pyrimidine were synthesized and evaluated for antianxiety properties via gross behavioral observations in rats. Five of these compounds, including 5,7-dimethylpyrazolo[1,5-a]pyrimidine (6) and the 3-fluoro (7), 3- ... Full text Cite

Drugs derived from cannabinoids. 5. Delta 6a, 10a-tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains.

Journal Article Journal of Medicinal Chemistry · April 1976 Ten new delta6a,10a-THC analogs with arylalkyl side chains, one with a dimethylaminoalkyl side chain, and six heterocyclic delta6a,10a-THC analogs [8-substituted 5,5-dimethyl-10-hydroxy-2-(2-propynyl)-1,2,3,4-tetrahydro-5H-[1]benzo-pyrano[4,3-c]pyridines] ... Cite

Drugs derived from cannabinoids. 3. Sulfur analogs, thiopyranobenzopyrans and thienobenzopyrans.

Journal Article Journal of medicinal chemistry · April 1976 Sulfur analogs of cannabinoids corresponding to DMHP(1) were prepared using the Pechmann condensation between the appropriate keto ester and 5-(1,2-dimethyl(eptyl)resorcnol, followeed by Grignard reaction. Compounds of various structural types (2-6) were f ... Full text Cite

Drugs derived from cannabinoids. 2. Basic esters of nitrogen and carbocyclic analogs.

Journal Article Journal of medicinal chemistry · April 1976 Various basic esters of nitrogen (2) and carbocyclic (3 and 4) analogs of cannabinoids were synthesized using dicyclohexylcarbodiimide in methylene chloride. The compounds in the three series werw studied in selected pharmacological tests in mice, rats, do ... Full text Cite

Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs.

Journal Article Journal of medicinal chemistry · April 1976 Various CNS-active cannabinoids in which the alicyclic ring was thiopheno, cyclopenteno, or cyclohexeno with the alkyl substituent in various positions (structural types 1-6) were synthesized by procedures described previously. These compounds were compare ... Full text Cite

Cholinergic and adrenergic activating agents as antagonists of the EEG effects of hemicholinium-3.

Journal Article Archives internationales de pharmacodynamie et de therapie · September 1968 Cite

Effects of hemicholinium (HC-3) on EEG activation and brain acetylcholine in the dog.

Journal Article The Journal of pharmacology and experimental therapeutics · May 1968 Cite

EEG Evaluation of Drug Action

Journal Article INTEK · 1968 Cite

Role of cholinergic mechanisms in states of wakefulness and sleep.

Journal Article Progress in brain research · January 1968 Full text Cite