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Ying Xian

Ying Xian

Adjunct Associate Professor in the Department of Neurology
Neurology, Neurocritical Care
200 Morris St, Duke Box 3850, Durham, NC 27701
PO Box 17969, Durham, NC 27715

Selected Publications

Hospital Implementation of Endovascular Thrombectomy and Health Equity in Acute Stroke Outcomes.

Journal Article Stroke · November 2025 BACKGROUND: The introduction of novel therapeutics into clinical practice could impact equity in health outcomes. METHODS: This was a retrospective, observational cohort study based on the Get With The Guidelines-Stroke program of the American Heart Associ ... Full text Link to item Cite

Intracerebral Hemorrhage Outcomes After Reversal of Subtherapeutic Warfarin: Analysis of Data From GWTG-Stroke.

Journal Article Stroke · November 2025 BACKGROUND: Current guidelines recommend reversal of warfarin anticoagulation in intracranial hemorrhages. The benefit of reversing subtherapeutic warfarin anticoagulation in acute spontaneous intracerebral hemorrhage is uncertain. METHODS: An observationa ... Full text Link to item Cite

Cardiovascular Multimorbidity in Older Adults in the United States by Race and Sex.

Journal Article JACC Adv · October 21, 2025 BACKGROUND: It is essential to understand the prevalence of cardiovascular multimorbidity and to recognize disparities by race and sex to promote health equity. OBJECTIVES: The objectives of the study are to investigate disparities in the development and p ... Full text Link to item Cite

Association of Component Strategies of the Target Stroke Phase 3 Nationwide Quality Improvement Program With Accelerated Door-to-Puncture and Door-In-Door-Out Times for Ischemic Stroke Endovascular Thrombectomy in the United States.

Journal Article Circ Cardiovasc Qual Outcomes · October 20, 2025 BACKGROUND: The Target Stroke Phase III program is a national quality improvement initiative led by the American Heart Association, which sought to improve the quality of care for patients with acute stroke undergoing acute reperfusion therapy including en ... Full text Link to item Cite

National Versus State-Level Racial Disparities in Acute Stroke Interventions Using Get With The Guidelines-Stroke Data.

Journal Article Stroke · October 2025 BACKGROUND: Racial disparities have been reported in stroke care, but understanding if there is regional variability is critical to focusing policies and resources. Here, we sought to study racial and ethnic inequity in the administration of thrombolysis a ... Full text Link to item Cite

Sex Differences in Mortality and Health Care Utilization After Dementia Diagnosis.

Journal Article JAMA Neurol · October 1, 2025 IMPORTANCE: Sex differences may contribute to disparities in dementia outcomes. OBJECTIVE: To understand the association between sex and mortality and health care services use after dementia diagnosis. DESIGN, SETTING, AND PARTICIPANTS: This nationwide coh ... Full text Link to item Cite

Incidence and prevalence of dementia among US Medicare beneficiaries, 2015-21: population based study.

Journal Article BMJ · May 20, 2025 OBJECTIVE: To determine the incidence and prevalence of dementia in a nationally representative cohort of US Medicare beneficiaries, stratified by important subgroups. DESIGN: Population based study. SETTING: Nationwide study between 2015 and 2021. PARTICI ... Full text Link to item Cite

Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke.

Journal Article JAMA Netw Open · March 3, 2025 IMPORTANCE: Tenecteplase is an alternative to alteplase for emergency treatment of acute ischemic stroke. However, limited data are available comparing their clinical effectiveness in routine clinical practice. OBJECTIVE: To compare short-term effectivenes ... Full text Link to item Cite

Prourokinase vs Standard Care for Patients With Mild Ischemic Stroke: The PUMICE Randomized Clinical Trial.

Journal Article JAMA Neurol · March 1, 2025 IMPORTANCE: Trials have not demonstrated superiority of alteplase or tenecteplase vs standard care in patients with mild stroke and have raised safety concerns. Prourokinase is an alternative fibrinolytic that may have a favorable safety profile, and the b ... Full text Link to item Cite

Atrial Fibrillation and Retinal Stroke.

Journal Article JAMA Netw Open · January 2, 2025 IMPORTANCE: Atrial fibrillation (AF) is the most common, chronic, cardiac arrythmia in older US adults. It is not known whether AF is independently associated with increased risk of retinal stroke (central retinal artery occlusion), a subtype of ischemic s ... Full text Link to item Cite

Racial and ethnic disparities in longitudinal trajectories of cardiovascular risk factors in U.S. middle-aged and older adults.

Journal Article PLoS One · 2025 BACKGROUND: Racial and ethnic disparities in cardiovascular disease (CVD) risk factors are well-documented. However, racial and ethnic differences in the longitudinal changes among multiple CVD risk factors are unknown. METHODS: We used prospective cohort ... Full text Link to item Cite

The Impact of Later-Life Learning on Trajectories of Cognitive Function Among U.S. Older Adults.

Journal Article Innovation in aging · January 2025 Background and objectivesLow education in early life is a major risk factor for dementia. However, little is known about how education in later life is related to cognitive function in older adults. We assessed whether later-life learning was asso ... Full text Cite

Rationale and design of the GOLDEN BRIDGE II: a cluster-randomised multifaceted intervention trial of an artificial intelligence-based cerebrovascular disease clinical decision support system to improve stroke outcomes and care quality in China.

Journal Article Stroke Vasc Neurol · December 30, 2024 BACKGROUND: Given the swift advancements in artificial intelligence (AI), the utilisation of AI-based clinical decision support systems (AI-CDSSs) has become increasingly prevalent in the medical domain, particularly in the management of cerebrovascular di ... Full text Link to item Cite

Care Quality and Outcomes of Ischemic Stroke in Patients With Premorbid Dementia: Get With The Guidelines-Stroke Registry.

Journal Article Stroke · December 2024 BACKGROUND: Patients with premorbid dementia have been generally excluded from trials of stroke therapies, and their dementia diagnosis may affect the care received. There are few data on the quality of stroke care and outcomes in these patients. METHODS: ... Full text Link to item Cite

Mobile Stroke Unit Management in Patients With Acute Ischemic Stroke Eligible for Intravenous Thrombolysis.

Journal Article JAMA Neurol · December 1, 2024 IMPORTANCE: Clinical trials have suggested that prehospital management in a mobile stroke unit (MSU) improves functional outcomes in patients with acute ischemic stroke who are potentially eligible for intravenous thrombolysis, but there is a paucity of re ... Full text Link to item Cite

Abstract 4145944: Disparities in Cardiovascular Multimorbidity and Mortality among Dual Medicare-Medicaid Beneficiaries: A Nationwide Cohort Study of >2 Million Patients

Conference Circulation · November 12, 2024 Introduction/Background: Patients dually eligible for Medicare and Medicaid have higher mortality rates and disparate outcomes for acute cardiovascular conditions. However, the association between dua ... Full text Cite

Abstract 4145883: Elevated International Normalized Ratio Is Associated with Severity of Intracerebral Hemorrhage for Patients Taking Direct Oral Anticoagulants

Conference Circulation · November 12, 2024 Introduction/Background: While the international normalized ratio (INR), a marker of functioning of the extrinsic and final common pathways of the coagulation cascade is associated with increased intr ... Full text Cite

Thrombolysis for ischaemic stroke despite direct oral anticoagulation.

Journal Article Stroke Vasc Neurol · November 5, 2024 Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants (DOACs) and a recent intake within the last 48 hours in US and European guidelines. However, three observational studies now suggest safety of throm ... Full text Link to item Cite

Migraine May Represent an Independent Risk Factor for Retinal Stroke: A Population-Based Cohort Study.

Journal Article Clin Neurol Neurosurg · November 2024 INTRODUCTION: Migraine is an established risk factor for cerebral ischemic stroke, with an especially robust association in patients with migraine with aura. However, it is not known if migraine is a risk factor for retinal stroke (central or branch retina ... Full text Link to item Cite

Twenty Years of Sustained Improvement in Quality of Care and Outcomes for Patients Hospitalized With Stroke or Transient Ischemic Attack: Data From The Get With The Guidelines-Stroke Program.

Journal Article Stroke · November 2024 BackgroundThe Get With The Guidelines-Stroke program is a quality improvement initiative designed to enhance adherence to evidence-based stroke care. Since its inception in 2003, over 2800 hospitals in the United States have participated in the pr ... Full text Cite

Prospective study on immune function in renal transplant patients during perioperative period: A prospective cohort study

Journal Article Medicine · October 18, 2024 Delayed graft function (DGF) is a type of acute renal failure that is closely linked to the immune system. The objective of this study is to investigate immune trends during the perioperative period of renal transplantation and compare the variatio ... Full text Cite

Prediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research.

Journal Article Neurology · June 11, 2024 OBJECTIVES: A reliable method of predicting large vessel occlusion (LVO) stroke in data sets without neuroimaging could be retrospectively applied to expand research efforts. METHODS: We conducted a retrospective, cross-sectional cohort analysis of the Get ... Full text Link to item Cite

Racial Disparities in Low-Value Care in the Last Year of Life for Medicare Beneficiaries With Neurodegenerative Disease.

Journal Article Neurol Clin Pract · April 2024 BACKGROUND AND OBJECTIVES: There are racial disparities in health care services received by patients with neurodegenerative diseases, but little is known about disparities in the last year of life, specifically in high-value and low-value care utilization. ... Full text Link to item Cite

Time to Anticoagulation Reversal and Outcomes After Intracerebral Hemorrhage.

Journal Article JAMA Neurol · February 9, 2024 IMPORTANCE: Intracerebral hemorrhage (ICH) is the deadliest stroke subtype, and mortality rates are especially high in anticoagulation-associated ICH. Recently, specific anticoagulation reversal strategies have been developed, but it is not clear whether t ... Full text Open Access Link to item Cite

Trends in Stroke Thrombolysis Care Metrics and Outcomes by Race and Ethnicity, 2003-2021.

Journal Article JAMA Netw Open · February 5, 2024 IMPORTANCE: Understanding is needed of racial and ethnic-specific trends in care quality and outcomes associated with the US nationwide quality initiative Target: Stroke (TS) in targeting thrombolysis treatment for acute ischemic stroke. OBJECTIVE: To exam ... Full text Open Access Link to item Cite

Abstract 43: Race-Ethnic Specific Trends in Stroke Thrombolysis Care Metrics in Relation to U.S. Target: Stroke Nationwide Quality Improvement Program 2003-2021

Conference Stroke · February 2024 Objectives: To examine whether thrombolysis care metrics have improved in all races and ethnicities with the launch and advance of Target: Stroke (TS) national quality initiatives. ... Full text Cite

Abstract 24: Differences in Door to Needle and Door In Door Out Times for Tenecteplase vs Alteplase in Acute Ischemic Stroke: Findings From Get With the Guidelines Stroke

Conference Stroke · February 2024 Introduction: Tenecteplase (TNK) has arisen as an alternative to alteplase (ALT) for emergent treatment of acute ischemic stroke. Shorter times to prepare and administer TNK raises the possibility tha ... Full text Cite

Abstract WP252: MARS: Migraine and Retinal Stroke - A Population-Based Cohort Study of 39 Million Patients

Conference Stroke · February 2024 Introduction: Migraine is a risk factor for cerebral ischemic stroke. However, it is not known if migraine is a risk factor for retinal stroke (central retinal artery occlusion, CRAO). Full text Cite

Abstract 145: Anticoagulation-Related Intracerebral Hemorrhage and Time to Reversal Treatment After Intracerebral Hemorrhage in the United States

Conference Stroke · February 2024 Background: Anticoagulation-associated intracerebral hemorrhage (AC-ICH) often results in death. Specific reversal agents are available, but it is not clear whether there is a time-dependent treatment ... Full text Cite

Performance of Thrombectomy-Capable, Comprehensive, and Primary Stroke Centers in Reperfusion Therapies for Acute Ischemic Stroke: Report From the Get With The Guidelines-Stroke Registry.

Journal Article Circulation · December 19, 2023 BACKGROUND: The thrombectomy-capable stroke center (TSC) is a recently introduced intermediate tier of accreditation for hospitals at which patients with acute ischemic stroke receive care. The comparative quality and clinical outcomes of reperfusion thera ... Full text Link to item Cite

Association between perceived risk of Alzheimer's disease and related dementias and cognitive function among U.S. older adults.

Journal Article Arch Gerontol Geriatr · December 2023 INTRODUCTION: The aim of the study was to assess factors associated with the perceived risk of developing Alzheimer's disease and related dementias (ADRD) and how the perceived risk of ADRD was related to cognitive function. METHODS: We conducted a retrosp ... Full text Open Access Link to item Cite

Traditional Chinese Medicine Compound (Tongxinluo) and Clinical Outcomes of Patients With Acute Myocardial Infarction: The CTS-AMI Randomized Clinical Trial.

Conference JAMA · October 24, 2023 IMPORTANCE: Tongxinluo, a traditional Chinese medicine compound, has shown promise in in vitro, animal, and small human studies for myocardial infarction, but has not been rigorously evaluated in large randomized clinical trials. OBJECTIVE: To investigate ... Full text Link to item Cite

Higher Procedural Volumes Are Associated with Faster Treatment Times, Better Functional Outcomes, and Lower Mortality in Patients Undergoing Endovascular Treatment for Acute Ischemic Stroke.

Journal Article Ann Neurol · September 20, 2023 OBJECTIVE: We aimed to characterize the association of hospital procedural volumes with outcomes among acute ischemic stroke (AIS) patients undergoing endovascular therapy (EVT). METHODS: This was a retrospective, observational cohort study using data pros ... Full text Link to item Cite

Correlation of serum albumin level on postoperative day 2 with hospital length of stay in patients undergoing emergency surgery for perforated peptic ulcer

Journal Article World Journal of Gastrointestinal Surgery · July 27, 2023 Obstructive jaundice (OJ) is a common problem in daily clinical practice. However, completely understanding the pathophysiological changes in OJ remains a challenge for planning current and future management. The effects of OJ are widespread, affec ... Full text Cite

Shorter Door-to-Needle Times Are Associated With Better Outcomes After Intravenous Thrombolytic Therapy and Endovascular Thrombectomy for Acute Ischemic Stroke.

Journal Article Circulation · July 4, 2023 BACKGROUND: Existing data and clinical trials could not determine whether faster intravenous thrombolytic therapy (IVT) translates into better long-term functional outcomes after acute ischemic stroke among those treated with endovascular thrombectomy (EVT ... Full text Open Access Link to item Cite

Recent Vitamin K Antagonist Use and Intracranial Hemorrhage After Endovascular Thrombectomy for Acute Ischemic Stroke.

Journal Article JAMA · June 20, 2023 IMPORTANCE: Use of oral vitamin K antagonists (VKAs) may place patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke caused by large vessel occlusion at increased risk of complications. OBJECTIVE: To determine the association betwee ... Full text Link to item Cite

Effect of the Shanghai Stroke Service System (4S) on the quality of stroke care and outcomes: A prospective quality improvement project.

Journal Article Int J Stroke · June 2023 BACKGROUND: In China, disparities in the quality of stroke care still exist and implementing quality improvement is still a challenge. AIM: The aim of the study was to determine whether the intervention by Shanghai Stroke Service System (4S) has helped imp ... Full text Link to item Cite

Racial/ethnic disparities in dementia incidence, outcomes, and health-care utilization.

Journal Article Alzheimers Dement · June 2023 INTRODUCTION: Racial/ethnic disparities exist in many aspects of health care, but data on racial/ethnic disparities for neurodegenerative diseases (NDDs), such as dementia and Parkinson's disease (PD), are limited. METHODS: We used North and South Carolina ... Full text Link to item Cite

Effectiveness of a Quality Improvement Intervention on Reperfusion Treatment for Patients With Acute Ischemic Stroke: A Stepped-Wedge Cluster Randomized Clinical Trial.

Journal Article JAMA Netw Open · June 1, 2023 IMPORTANCE: Reperfusion therapy is the most effective treatment for acute ischemic stroke but remains underused in China. OBJECTIVE: To evaluate the effect of a problem-oriented, culturally adapted, targeted quality improvement intervention on reperfusion ... Full text Link to item Cite

Association Between Hospital-Documented Atrial Fibrillation and Central Retinal Artery Occlusion.

Journal Article Stroke · April 2023 BACKGROUND: Carotid stenosis is thought to be the primary risk factor for central retinal artery occlusion (CRAO); however, it is not known whether atrial fibrillation (AF)-a cardiac arrhythmia that underlies over 25% of cerebral ischemic strokes-predispos ... Full text Link to item Cite

Long-term outcomes of aortic root operations in the United States among Medicare beneficiaries.

Journal Article J Thorac Cardiovasc Surg · February 2023 OBJECTIVE: The best method of aortic root repair in older patients remains unknown given a lack of comparative effectiveness of long-term outcomes data. The objective of this study was to compare long-term outcomes of different surgical approaches for aort ... Full text Link to item Cite

Temporal trends and rural-urban disparities in cerebrovascular risk factors, in-hospital management and outcomes in ischaemic strokes in China from 2005 to 2015: a nationwide serial cross-sectional survey.

Journal Article Stroke Vasc Neurol · February 2023 BACKGROUND: Stroke is the leading cause of mortality in China, with limited evidence of in-hospital burden obtained from nationwide surveys. We aimed to monitor and track the temporal trends and rural-urban disparities in cerebrovascular risk factors, mana ... Full text Link to item Cite

Abstract 30: Association Between Hospital-ascertained Atrial Fibrillation And Central Retinal Artery Occlusion: A Study Of 12 Million Patients

Conference Stroke · February 2023 Introduction: Atrial fibrillation (AF) is a major risk factor for cerebral ischemic stroke. However, it is not known whether AF predicts the development of central retinal artery occlusion (CRAO), a f ... Full text Cite

Abstract TMP47: IMPROVING Time To Anti-Coagulation Reversal For Hemorrhagic Strokes

Conference Stroke · February 2023 Background: Oral anticoagulation (OAC) is a risk factor for intracerebral hemorrhage (ICH) which is an important source of disability and mortality. OAC-associated ICH (OAC-ICH) patients have worse ou ... Full text Cite

Abstract TP116: Procoagulant Reversal Of Warfarin After Intracranial Hemorrhage Is Not Associated With Improved Functional Outcome When Coagulation Is Abnormal Without Full Anticoagulation

Conference Stroke · February 2023 Introduction: Although the current guidelines recommend procoagulant reversal of elevated INR >= 2.0 (International Normalized Ratio) in patients with intracranial hemorrhage using warfarin, the be ... Full text Cite

Abstract 67: Endovascular Thrombectomy In Patients With Acute Ischemic Stroke And Recent Use Of Oral Vitamin K-Antagonists: The Get With The Guidelines-Stroke Program

Conference Stroke · February 2023 Introduction: Emergent endovascular thrombectomy (EVT) is effective in improving outcomes in patients with stroke caused by large vessel occlusion. However, there are limited data on the use of EVT in ... Full text Cite

Abstract 78: Neighborhood Socioeconomic Deprivation Is Associated With Increased 30-day Mortality After Stroke: Results From A Nationwide Study Of 755,899 Medicare Patients

Conference Stroke · February 2023 Introduction: The relationship between neighborhood socioeconomic deprivation- a reflection of the general economic and environmental conditions of a neighborhood- and outcomes after stroke is not kno ... Full text Cite

Abstract 25: Safety And Outcomes Of Endovascular Thrombectomy In Acute Ischemic Stroke Patients With Recent Use Of Non-vitamin K Antagonist Oral Anticoagulants

Conference Stroke · February 2023 Introduction: An increasing number of patients with acute ischemic stroke (AIS) have recently used non-vitamin K antagonist oral anticoagulants (NOACs). However, there are limited data on safety of en ... Full text Cite

Predictive Accuracy of Stroke Risk Prediction Models Across Black and White Race, Sex, and Age Groups.

Journal Article JAMA · January 2023 ImportanceStroke is the fifth-highest cause of death in the US and a leading cause of serious long-term disability with particularly high risk in Black individuals. Quality risk prediction algorithms, free of bias, are key for comprehensive preven ... Full text Cite

Atrial fibrillation as a novel risk factor for retinal stroke: A protocol for a population-based retrospective cohort study.

Journal Article PLoS One · 2023 Central retinal artery occlusion (CRAO; retinal stroke or eye stroke) is an under-recognized, disabling form of acute ischemic stroke which causes severe visual loss in one eye. The classical risk factor for CRAO is ipsilateral carotid stenosis; however, n ... Full text Link to item Cite

Time to Endovascular Reperfusion and Outcome in Acute Ischemic Stroke : A Nationwide Prospective Registry in China.

Journal Article Clin Neuroradiol · December 2022 PURPOSE: The benefit of endovascular reperfusion therapy for acute ischemic stroke is highly time-dependent but the relation of delays in workflow with outcomes and the key determinants of delays remain uncertain. This study aimed to evaluate the associati ... Full text Link to item Cite

Incidence of Poststroke Epilepsy: An Executive Summary.

Journal Article J Neurosci Nurs · December 1, 2022 Full text Link to item Cite

US Surveillance of Acute Ischemic Stroke Patient Characteristics, Care Quality, and Outcomes for 2019.

Journal Article Stroke · November 2022 BACKGROUND: The United States lacks a timely and accurate nationwide surveillance system for acute ischemic stroke (AIS). We use the Get With The Guidelines-Stroke registry to apply poststratification survey weights to generate national assessment of AIS e ... Full text Link to item Cite

Sex Differences in Endovascular Therapy for Ischemic Stroke: Results From the Get With The Guidelines-Stroke Registry.

Journal Article Stroke · October 2022 BACKGROUND: In 2015, endovascular therapy (EVT) for large vessel occlusions became standard of care for acute ischemic stroke. Lower utilization of IV alteplase has been reported in women, but whether sex differences in EVT use in the United States exists ... Full text Link to item Cite

Rationale and design of a stepped wedge cluster randomised trial to improve acute reperfusion treatment quality for stroke: IMPROVE stroke care in China.

Journal Article Stroke Vasc Neurol · October 2022 BACKGROUND: Reperfusion therapy is the most effective treatment for acute ischaemic stroke (AIS) but remains underutilised in China. There is an urgent need to develop tailored strategies to increase adherence to intravenous thrombolysis (IVT) and endovasc ... Full text Link to item Cite

Cerebral Oximetry During Adult Cardiac Surgery Is Associated With Improved Postoperative Outcomes.

Journal Article J Cardiothorac Vasc Anesth · September 2022 OBJECTIVE: To examine the association/effect of intraoperative cerebral oximetry (CeOx) on major organ morbidity and mortality (MOMM) after adult cardiac surgery. DESIGN: A retrospective, multicenter cohort study. SETTING: Patients treated at any hospital ... Full text Link to item Cite

LDL-C levels, lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA.

Journal Article Stroke Vasc Neurol · August 2022 BACKGROUND AND PURPOSE: Dyslipidaemia is a major risk factor for ischaemic stroke and transient ischaemic attack (TIA). This study aimed to investigate the association between baseline low-density lipoprotein cholesterol (LDL-C) level, lipid-lowering treat ... Full text Link to item Cite

Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice.

Journal Article JAMA Neurol · August 1, 2022 IMPORTANCE: The effectiveness and safety of intravenous alteplase given before or concurrently with endovascular thrombectomy (EVT) is uncertain. Randomized clinical trials suggest there is little difference in outcomes but with only modest precision and i ... Full text Open Access Link to item Cite

Anticoagulation in new-onset postoperative atrial fibrillation: An analysis from the Society of Thoracic Surgeons Adult Cardiac Surgery Database.

Journal Article Heart Rhythm O2 · August 2022 BACKGROUND: New-onset postoperative atrial fibrillation (POAF) is the most common complication after cardiac surgery and is associated with increased long-term stroke and mortality. Anticoagulation has been suggested as a potential therapy, but data on saf ... Full text Link to item Cite

Analysis of Prescriptions for Dual Antiplatelet Therapy After Acute Ischemic Stroke.

Journal Article JAMA Netw Open · July 1, 2022 IMPORTANCE: After the publication of the CHANCE (Clopidogrel in High Risk Patients With Acute Nondisabling Cerebrovascular Events) and POINT (Platelet-Oriented Inhibition in New Transient Ischemic Attack and Minor Ischemic Stroke) clinical trials, the Amer ... Full text Link to item Cite

Trends in Use, Outcomes, and Disparities in Endovascular Thrombectomy in US Patients With Stroke Aged 80 Years and Older Compared With Younger Patients.

Journal Article JAMA Netw Open · June 1, 2022 IMPORTANCE: Patients aged 80 years and older were often excluded or underrepresented in pivotal endovascular thrombectomy (EVT) trials. Accordingly, trends in frequency, outcomes, and disparities of EVT use merit close analysis. OBJECTIVE: To delineate tem ... Full text Link to item Cite

Hydration for prevention of kidney injury after primary coronary intervention for acute myocardial infarction: a randomised clinical trial.

Journal Article Heart · May 25, 2022 OBJECTIVE: To evaluate the efficacy of aggressive hydration compared with general hydration for contrast-induced acute kidney injury (CI-AKI) prevention among patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary ... Full text Link to item Cite

Evaluation of Evidence-Based Dual Antiplatelet Therapy for Secondary Prevention in US Patients With Acute Ischemic Stroke.

Journal Article JAMA Intern Med · May 1, 2022 This cohort study examines patterns in prescriptions of dual antiplatelet therapy after publication of important trials and release of updated guidelines. ... Full text Link to item Cite

Race-Ethnic Disparities in Rates of Declination of Thrombolysis for Stroke.

Journal Article Neurology · April 19, 2022 BACKGROUND AND OBJECTIVES: Prior regional or single-center studies have noted that 4% to 7% of eligible patients with acute ischemic stroke (AIS) decline IV tissue plasminogen activator (tPA). We sought to determine the prevalence of tPA declination in a n ... Full text Open Access Link to item Cite

Achieving More Rapid Door-to-Needle Times and Improved Outcomes in Acute Ischemic Stroke in a Nationwide Quality Improvement Intervention.

Journal Article Stroke · April 2022 BACKGROUND: The benefits of tPA (tissue-type plasminogen activator) in acute ischemic stroke are time-dependent. However, delivery of thrombolytic therapy rapidly after hospital arrival was initially occurring infrequently in hospitals in the United States ... Full text Link to item Cite

Association Between Endovascular Therapy Time to Treatment and Outcomes in Patients With Basilar Artery Occlusion.

Journal Article Circulation · March 22, 2022 BACKGROUND: Basilar artery occlusion (BAO) is a devastating condition without definitive evidence to guide treatment. Whereas the association between faster treatment times with endovascular therapy (EVT) and better outcomes in anterior circulation is well ... Full text Link to item Cite

Temporal Trends in Racial and Ethnic Disparities in Endovascular Therapy in Acute Ischemic Stroke.

Journal Article J Am Heart Assoc · March 15, 2022 Introduction Endovascular therapy (EVT) use increased following clinical trials publication in 2015, but limited data suggest there may be persistent race and ethnicity differences. Methods and Results We included all patients with acute ischemic stroke ar ... Full text Link to item Cite

Association Between Inappropriately Dosed Anticoagulation Therapy With Stroke Severity and Outcomes in Patients With Atrial Fibrillation.

Journal Article J Am Heart Assoc · March 15, 2022 Background Oral anticoagulation (OAC) is effective for stroke prevention in patients with atrial fibrillation. However, some patients experience stroke despite OAC therapy, and knowledge about the impact of prior treatment quality is lacking. Methods and R ... Full text Link to item Cite

Association of Recent Use of Non-Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase.

Journal Article JAMA · February 22, 2022 IMPORTANCE: Current guidelines recommend against use of intravenous alteplase in patients with acute ischemic stroke who are taking non-vitamin K antagonist oral anticoagulants (NOACs). OBJECTIVE: To evaluate the safety and functional outcomes of intraveno ... Full text Link to item Cite

Advances in the management of cardioembolic stroke associated with patent foramen ovale.

Journal Article BMJ · February 9, 2022 Patent foramen ovale (PFO) describes a valve in the interatrial septum that permits shunting of blood or thrombotic material between the atria. PFOs are present in approximately 25% of the healthy population and are not associated with any pathology in the ... Full text Link to item Cite

Hyperglycemia, Risk of Subsequent Stroke, and Efficacy of Dual Antiplatelet Therapy: A Post Hoc Analysis of the POINT Trial.

Journal Article J Am Heart Assoc · February 2022 Background One-quarter of all strokes are subsequent events. It is not known whether higher levels of blood glucose are associated with an increased risk of subsequent stroke after high-risk transient ischemic attack or minor ischemic stroke. Methods and R ... Full text Link to item Cite

Abstract 116: Unmet Need In Acute Ischemic Stroke Patients Not Treated With Alteplase

Conference Stroke · February 2022 Introduction: Early administration of intravenous tissue plasminogen activator (IV alteplase) improves functional outcomes in patients with acute ischemic stroke (AIS), yet many patients are not treat ... Full text Cite

Abstract 35: Unmet Need In Acute Ischemic Stroke Patients Arriving After 4.5 Hours

Conference Stroke · February 2022 Introduction: Many patients arrive beyond the guideline-recommended time window for treatment with IV alteplase. For most of these patients, few treatment options exist. There is a need to understand ... Full text Cite

Abstract WP194: Ldlc Levels, Lipid Lowering Treatment And Recurrent Stroke In Minor Ischemic Stroke Or Tia

Conference Stroke · February 2022 Objective: To investigate the association between baseline low-density lipoprotein cholesterol (LDL-C) level, lipid lowering treatment and short-term risk of new stroke in patients with a minor ischem ... Full text Cite

Frequency, Characteristics, and Outcomes of Endovascular Thrombectomy in Patients With Stroke Beyond 6 Hours of Onset in US Clinical Practice.

Journal Article Stroke · December 2021 BACKGROUND AND PURPOSE: In 2018, 2 randomized controlled trials showed the benefit of endovascular thrombectomy (EVT) in acute ischemic stroke patients treated 6 to 24 hours from last known well using imaging-guided selection. However, little is known abou ... Full text Link to item Cite

Antithrombotic Therapy for Stroke Prevention in Patients With Ischemic Stroke With Aspirin Treatment Failure.

Journal Article Stroke · December 2021 BACKGROUND AND PURPOSE: Many older patients presenting with acute ischemic stroke were already taking aspirin before admission. However, the management strategy for patients with aspirin treatment failure has not been fully established. METHODS: We used da ... Full text Link to item Cite

Outcomes of Endovascular Therapy in Patients With Prestroke Mobility Impairment.

Conference Stroke · November 2021 BACKGROUND AND PURPOSE: Patients with prestroke mobility impairment (PSMI) were excluded from endovascular clinical trials. There are limited data regarding safety and outcomes of endovascular thrombectomy in this population. We used a large, national data ... Full text Link to item Cite

Outcomes of Endovascular Therapy in Patients With Prestroke Mobility Impairment

Journal Article Stroke · November 2021 Background and Purpose:Patients with prestroke mobility impairment (PSMI) were excluded from endovascular clinical trials. There are limited data regarding safety and outcomes of endovasc ... Full text Cite

Associations of Medicaid Expansion With Access to Care, Severity, and Outcomes for Acute Ischemic Stroke.

Journal Article Circ Cardiovasc Qual Outcomes · October 2021 BACKGROUND: Multiple states have not expanded Medicaid under the Affordable Care Act, resulting in higher uninsured rates in states with high stroke burdens. This study aimed to evaluate the association of Medicaid expansion with changes in health insuranc ... Full text Link to item Cite

Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors.

Journal Article Stroke Vasc Neurol · September 2021 BACKGROUND AND PURPOSE: Depression is common after stroke and is often treated with antidepressant medications (AD). ADs have also been hypothesised to improve stroke recovery, although recent randomised trials were neutral. We investigated the patterns of ... Full text Link to item Cite

Association Between 2010 Medicare Reform and Inpatient Rehabilitation Access in People With Intracerebral Hemorrhage.

Journal Article J Am Heart Assoc · August 17, 2021 Background Evidence suggests intracerebral hemorrhage survivors have earlier recovery compared with ischemic stroke survivors. The Centers for Medicare and Medicaid Services prospective payment system instituted documentation rules for inpatient rehabilita ... Full text Link to item Cite

Association Between Hospital Volumes and Clinical Outcomes for Patients With Nontraumatic Subarachnoid Hemorrhage.

Journal Article J Am Heart Assoc · August 3, 2021 Background Previous studies of patients with nontraumatic subarachnoid hemorrhage (SAH) suggest better outcomes at hospitals with higher case and procedural volumes, but the shape of the volume-outcome curve has not been defined. We sought to establish min ... Full text Link to item Cite

Clinical Characteristics, Management, and In-Hospital Outcomes in Patients With Stroke or Transient Ischemic Attack in China.

Journal Article JAMA Netw Open · August 2, 2021 IMPORTANCE: Stroke represents a significant burden on the health care system of China. The Chinese Stroke Center Alliance was launched in 2015 to monitor and improve care quality and outcomes for patients with acute stroke and transient ischemic attack (TI ... Full text Link to item Cite

Oral Anticoagulation and Adverse Outcomes after Ischemic Stroke in Heart Failure Patients without Atrial Fibrillation.

Journal Article J Card Fail · August 2021 BACKGROUND: The safety and effectiveness of oral anticoagulation (OAC) after an ischemic stroke in older patients with heart failure (HF) without atrial fibrillation remains uncertain. METHODS: Utilizing Get With The Guidelines Stroke national clinical reg ... Full text Link to item Cite

Detection of Atrial Fibrillation After Central Retinal Artery Occlusion.

Journal Article Stroke · August 2021 BACKGROUND: Central retinal artery occlusion (CRAO) causes sudden, irreversible blindness and is a form of acute ischemic stroke. In this study, we sought to determine the proportion of patients in whom atrial fibrillation (AF) is detected by extended card ... Full text Open Access Link to item Cite

Application of high-throughput sequencing for hereditary thrombocytopenia in southwestern China.

Journal Article J Clin Lab Anal · August 2021 BACKGROUND: The aim of this study was to design and analyze the applicability of a 21-gene high-throughput sequencing (HTS) panel in the molecular diagnosis of patients with hereditary thrombocytopenia (HT). METHODS: A custom target enrichment library was ... Full text Link to item Cite

Association Between 2010 Medicare Reforms and Utilization of Postacute Inpatient Rehabilitation in Ischemic Stroke.

Journal Article Am J Phys Med Rehabil · July 1, 2021 OBJECTIVE: The aim of the study was to investigate whether the elimination of trial admissions and the initiation of documentation requirements, via the 2010 Centers for Medicare and Medicaid Services Inpatient Rehabilitation Facility Prospective Payment S ... Full text Link to item Cite

P2Y12 Inhibitors Plus Aspirin Versus Aspirin Alone in Patients With Minor Stroke or High-Risk Transient Ischemic Attack.

Journal Article Stroke · July 2021 BACKGROUND AND PURPOSE: We performed a systemic review and meta-analysis to elucidate the effectiveness and safety of dual antiplatelet (DAPT) therapy with P2Y12 inhibitors (clopidogrel/ticagrelor) and aspirin versus aspirin monotherapy in patients with mi ... Full text Link to item Cite

Assessment of Trends in Guideline-Based Oral Anticoagulant Prescription for Patients With Ischemic Stroke and Atrial Fibrillation in China.

Journal Article JAMA Netw Open · July 1, 2021 IMPORTANCE: Adherence to oral anticoagulants (OACs) per guideline recommendations is crucial in reducing ischemic stroke and systemic thromboembolism in high-risk patients with ischemic stroke and atrial fibrillation. However, data on OAC use are underrepo ... Full text Link to item Cite

Thrombolytic therapy for wake-up stroke: A systematic review and meta-analysis.

Journal Article European journal of neurology · June 2021 Background and purposeAccording to evidence-based clinical practice guidelines, patients presenting with disabling stroke symptoms should be treated with intravenous tissue plasminogen activator (IV tPA) within 4.5 h of time last known well. Howev ... Full text Cite

Effect of intervention timing on one-year mortality in elderly non-ST-segment elevation myocardial infarction patients.

Journal Article Coron Artery Dis · March 1, 2021 BACKGROUND: The best timing for early invasive therapy in non-ST-segment elevation myocardial infarction (NSTEMI) patients remains controversial. We sought to determine the optimal timing of early catheterization in order to improve long-term outcomes in e ... Full text Link to item Cite

Implementation of regional Acute Stroke Care Map increases thrombolysis rates for acute ischaemic stroke in Chinese urban area in only 3 months.

Journal Article Stroke Vasc Neurol · March 2021 BACKGROUND: The rate of intravenous thrombolysis for acute ischaemic stroke remains low in China. We investigated whether the implementation of a citywide Acute Stroke Care Map (ASCaM) is associated with an improvement of acute stroke care quality in a Chi ... Full text Open Access Link to item Cite

Changes in Informed Consent Policy and Treatment Delays in Stroke Thrombolysis.

Journal Article J Stroke Cerebrovasc Dis · March 2021 OBJECTIVES: The efficacy of thrombolytic therapy with tissue plasminogen activator (tPA) is highly time dependent. Although clinical guidelines do not recommend written informed consent as it may cause treatment delays, local policy can supersede and requi ... Full text Open Access Link to item Cite

Abstract P592: Admission Hyperglycemia is Associated With Subsequent Ischemic Stroke After Transient Ischemic Attack or Minor Stroke: A Secondary Analysis of the POINT Trial

Conference Stroke · March 2021 Introduction: Hyperglycemia is associated with increased lesion volume and worse functional outcome after acute ischemic stroke, however, it is not known whether it is associated with further cerebrov ... Full text Cite

Abstract MP46: Internal Carotid Artery Web and Acute Ischemic Stroke - A Systematic Review and Meta-Analysis

Conference Stroke · March 2021 Introduction: The carotid web is a compelling potential mechanism of embolic ischemic stroke. In this study, we perform a systematic review and meta-analysis to determine the prevalence of ipsilesiona ... Full text Cite

Abstract P252: Discharge Antithrombotic Therapy for Ischemic Stroke Patients With Prior Aspirin Failure

Conference Stroke · March 2021 Introduction: Aspirin is one of the most commonly used medications for cardiovascular disease and stroke prevention. Many older patients who present with a first or recurrent stroke are already on asp ... Full text Cite

National surveillance of stroke quality of care and outcomes by applying post-stratification survey weights on the Get With The Guidelines-Stroke patient registry.

Journal Article BMC Med Res Methodol · February 4, 2021 BACKGROUND: The U.S. lacks a stroke surveillance system. This study develops a method to transform an existing registry into a nationally representative database to evaluate acute ischemic stroke care quality. METHODS: Two statistical approaches are used t ... Full text Link to item Cite

Clinical Characteristics and Outcomes Associated With Oral Anticoagulant Use Among Patients Hospitalized With Intracerebral Hemorrhage.

Journal Article JAMA Netw Open · February 1, 2021 IMPORTANCE: Although the use of factor Xa (FXa) inhibitors has increased substantially over the past decade, there are limited data on characteristics and outcomes of FXa inhibitor-associated intracerebral hemorrhage (ICH). OBJECTIVE: To investigate the as ... Full text Link to item Cite

The Role of Diabetes Mellitus as an Effect Modifier of the Association Between Smoking Cessation and Its Clinical Prognoses: An Observational Cohort Study.

Journal Article Angiology · January 2021 The smoker's paradox refers to an increased risk of adverse clinical outcomes after smoking cessation in patients with coronary artery disease. The mechanisms involved are controversial. The present study evaluated the effect of delay in smoking cessation ... Full text Link to item Cite

Antiplatelet patterns and outcomes in patients with atrial fibrillation not prescribed an anticoagulant after stroke.

Journal Article Int J Cardiol · December 15, 2020 BACKGROUND: To determine association of discharge antiplatelet therapy prescription with 1-year outcomes among patients with AF admitted with acute ischemic stroke and discharged without oral anticoagulation. METHODS: In a retrospective cohort study from t ... Full text Link to item Cite

Trends in Reperfusion Therapy for In-Hospital Ischemic Stroke in the Endovascular Therapy Era.

Journal Article JAMA Neurol · December 1, 2020 IMPORTANCE: A significant proportion of acute ischemic strokes occur while patients are hospitalized. Limited contemporary data exist on the utilization rates of intravenous thrombolysis or endovascular therapy for in-hospital stroke. OBJECTIVE: To use a n ... Full text Open Access Link to item Cite

Target: Stroke Was Associated With Faster Intravenous Thrombolysis and Improved One-Year Outcomes for Acute Ischemic Stroke in Medicare Beneficiaries.

Journal Article Circ Cardiovasc Qual Outcomes · December 2020 BACKGROUND: The benefit of intravenous thrombolytic therapy for acute ischemic stroke is time dependent. To assist hospitals in providing faster thrombolytic treatment, the American Heart Association launched target: stroke quality initiative in January 20 ... Full text Link to item Cite

Application and Innovation of Informatization in Financial Economic Management

Conference 2020 5th International Conference on Mechanical, Control and Computer Engineering (ICMCCE) · December 2020 Full text Cite

Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study.

Journal Article Stroke Vasc Neurol · September 2020 BACKGROUND AND PURPOSE: COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Apart from respiratory complications, acute cerebrovascular disease (CVD) has been observed in some patients with COVID-19. Th ... Full text Link to item Cite

China Tongxinluo Study for myocardial protection in patients with Acute Myocardial Infarction (CTS-AMI): Rationale and design of a randomized, double-blind, placebo-controlled, multicenter clinical trial.

Journal Article Am Heart J · September 2020 Acute ST-segment elevation myocardial infarction (STEMI) remains a serious life-threatening event. Despite coronary revascularization, patients might still suffer from poor outcomes caused by myocardial no-reflow and ischemic/reperfusion injury. Tongxinluo ... Full text Link to item Cite

Concomitant carotid endarterectomy and cardiac surgery does not decrease postoperative stroke rates.

Journal Article J Vasc Surg · August 2020 OBJECTIVE: The timing of operative revascularization for patients with concomitant carotid artery stenosis and coronary artery disease remains controversial. We examined the Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database to evaluate the ... Full text Link to item Cite

Association Between Thrombolytic Door-to-Needle Time and 1-Year Mortality and Readmission in Patients With Acute Ischemic Stroke.

Journal Article JAMA · June 2, 2020 IMPORTANCE: Earlier administration of intravenous tissue plasminogen activator (tPA) in acute ischemic stroke is associated with reduced mortality by the time of hospital discharge and better functional outcomes at 3 months. However, it remains unclear whe ... Full text Open Access Link to item Cite

Random forest for prediction of contrast-induced nephropathy following coronary angiography.

Journal Article Int J Cardiovasc Imaging · June 2020 The majority of prediction models for contrast-induced nephropathy (CIN) have moderate performance. Therefore, we aimed to develop a better pre-procedural prediction tool for CIN following contemporary percutaneous coronary intervention (PCI) or coronary a ... Full text Link to item Cite

Emergency medical services use and its association with acute ischaemic stroke evaluation and treatment in Singapore.

Journal Article Stroke Vasc Neurol · June 2020 BACKGROUND: Emergency medical services (EMS) is a critical link in the chain of stroke survival. We aimed to assess EMS use for stroke in Singapore, identify characteristics associated with EMS use and the association of EMS use with stroke evaluation and ... Full text Open Access Link to item Cite

Risk Analysis and Outcomes of Postoperative Renal Failure After Aortic Valve Surgery in the United States.

Journal Article Ann Thorac Surg · April 2020 BACKGROUND: Postoperative renal failure (RF) compromises early outcomes in cardiac surgery. In contrast, long-term survival and progression of RF after aortic valve replacement (AVR) with or without coronary artery bypass graft surgery (CABG) remain undefi ... Full text Link to item Cite

Implementation of Best Practices-Developing and Optimizing Regional Systems of Stroke Care: Design and Methodology.

Journal Article Am Heart J · April 2020 The AHA Guidelines recommend developing multi-tiered systems for the care of patients with acute stroke.1 An ideal stroke system of care should ensure that all patients receive the most efficient and timely care, regardless of how they first enter or acces ... Full text Link to item Cite

Thrombolytic therapy in older acute ischemic stroke patients with gastrointestinal malignancy or recent bleeding.

Journal Article Eur Stroke J · March 2020 BACKGROUND: There are limited data on the safety of intravenous recombinant tissue plasminogen activator (rtPA) for treating acute ischemic stroke in patients with gastrointestinal malignancy or recent gastrointestinal bleeding within 21 days of their inde ... Full text Link to item Cite

Prognostic value of the GRACE discharge score for predicting the mortality of patients with stable coronary artery disease who underwent percutaneous coronary intervention.

Conference Catheter Cardiovasc Interv · February 2020 OBJECTIVES: To assess the predictive value of the Global Registry of Acute Coronary Events (GRACE) discharge score for patients with stable coronary artery disease (SCAD) after percutaneous coronary intervention (PCI). BACKGROUND: The GRACE score is widely ... Full text Link to item Cite

Racial Differences in Elevated C-Reactive Protein Among US Older Adults.

Journal Article J Am Geriatr Soc · February 2020 OBJECTIVES: To investigate racial differences in elevated C-reactive protein (CRP) and the potential factors contributing to these differences in US older men and women. DESIGN: Nationally representative cohort study. SETTING: Health and Retirement Study, ... Full text Link to item Cite

Safety and Outcomes of Intravenous tPA in Acute Ischemic Stroke Patients With Prior Stroke Within 3 Months: Findings From Get With The Guidelines-Stroke.

Journal Article Circ Cardiovasc Qual Outcomes · January 2020 Background Guidelines recommend against the use of intravenous tPA (tissue-type plasminogen activator; IV tPA) in acute ischemic stroke patients with prior ischemic stroke within 3 months. However, there are limited data on the safety of IV tPA in this pop ... Full text Link to item Cite

Effect of Lifestyle Changes after Percutaneous Coronary Intervention on Revascularization.

Journal Article Biomed Res Int · 2020 OBJECTIVE: Whether optimal cardiovascular health metrics may reduce the risk of cardiovascular events in secondary prevention is uncertain. The study was conducted to evaluate the influence of lifestyle changes on clinical outcomes among the subjects under ... Full text Open Access Link to item Cite

Probing the Effective Treatment Thresholds for Alteplase in Acute Ischemic Stroke With Regression Discontinuity Designs.

Journal Article Front Neurol · 2020 Randomized Controlled Trials (RCTs) are considered the gold standard for measuring the efficacy of medical interventions. However, RCTs are expensive, and use a limited population. Techniques to estimate the effects of stroke interventions from observation ... Full text Open Access Link to item Cite

The Medicare Shared Savings Program and Outcomes for Ischemic Stroke Patients: a Retrospective Cohort Study.

Journal Article J Gen Intern Med · December 2019 BACKGROUND: Post-stroke care delivery may be affected by provider participation in Medicare Shared Savings Program (MSSP) Accountable Care Organizations (ACOs) through systematic changes to discharge planning, care coordination, and transitional care. OBJE ... Full text Link to item Cite

Renal Dysfunction and In-Hospital Outcomes in Patients With Acute Ischemic Stroke After Intravenous Thrombolytic Therapy.

Journal Article J Am Heart Assoc · October 15, 2019 Background The impact of estimated glomerular filtration rate (eGFR) on clinical short-term outcomes after stroke thrombolysis with tissue plasminogen activator remains controversial. Methods and Results We analyzed 18 320 ischemic stroke patients who rece ... Full text Open Access Link to item Cite

Clinical Effectiveness of Direct Oral Anticoagulants vs Warfarin in Older Patients With Atrial Fibrillation and Ischemic Stroke: Findings From the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study.

Journal Article JAMA Neurol · October 1, 2019 IMPORTANCE: Current guidelines recommend direct oral anticoagulants (DOACs) over warfarin for stroke prevention in patients with atrial fibrillation (AF) who are at high risk. Despite demonstrated efficacy in clinical trials, real-world data of DOACs vs wa ... Full text Open Access Link to item Cite

Direct oral anticoagulant- versus vitamin K antagonist-related gastrointestinal bleeding: Insights from a nationwide cohort.

Journal Article Am Heart J · October 2019 BACKGROUND: The purpose of the study was to examine the association between the type of preceding oral anticoagulant use (warfarin or direct oral anticoagulants [DOACs]) and in-hospital mortality among patients admitted with gastrointestinal bleeding. METH ... Full text Link to item Cite

Intensity of Lipid Lowering With Statin Therapy in Patients With Cerebrovascular Disease Versus Coronary Artery Disease: Insights from the PALM Registry.

Journal Article J Am Heart Assoc · October 2019 Background Current treatment guidelines strongly recommend statin therapy for secondary prevention. However, it remains unclear whether patients' perceptions of cardiovascular risk, beliefs on cholesterol, or the intensity of prescribed statin therapy diff ... Full text Open Access Link to item Cite

Rationale and design of Patient-centered Retrospective Observation of Guideline-Recommended Execution for Stroke Sufferers in China: China PROGRESS.

Journal Article Stroke Vasc Neurol · September 2019 BACKGROUND: In 2009, China launched ambitious healthcare reform plans to provide affordable and equitable basic healthcare for all patients, including the substantial number of patients who had a stroke. However, little is known about the pattern of eviden ... Full text Link to item Cite

Efficacy of clopidogrel for stroke depends on CYP2C19 genotype and risk profile.

Journal Article Ann Neurol · September 2019 OBJECTIVE: Dual antiplatelet therapy (DAT) with clopidogrel plus aspirin has been suggested by American Heart Association/American Stroke Association guidelines for minor stroke (MS) and transient ischemic attack (TIA) patients. The purpose of this study w ... Full text Link to item Cite

Hospital distance, socioeconomic status, and timely treatment of ischemic stroke.

Journal Article Neurology · August 20, 2019 OBJECTIVE: To determine whether lower socioeconomic status (SES) and longer home to hospital driving time are associated with reductions in tissue plasminogen activator (tPA) administration and timeliness of the treatment. METHODS: We conducted a retrospec ... Full text Open Access Link to item Cite

Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy.

Journal Article J Am Heart Assoc · August 6, 2019 Background Intravenous recombinant tissue-type plasminogen activator (rtPA) remains the only medical therapy to improve outcomes for acute ischemic stroke (AIS), but the safety of rtPA in AIS patients with a history of recent myocardial infarction (MI) rem ... Full text Open Access Link to item Cite

Effect of a Quality Improvement Intervention on Adherence to Therapies for Patients With Acute Ischemic Stroke and Transient Ischemic Attack: A Cluster Randomized Clinical Trial.

Journal Article JAMA Neurol · August 1, 2019 IMPORTANCE: Translating evidence into clinical practice in the management of acute ischemic stroke (AIS) and transient ischemic attack (TIA) is challenging, especially in low- and middle-income countries. OBJECTIVE: To assess the effect of a multifaceted q ... Full text Open Access Link to item Cite

Intravenous Tissue Plasminogen Activator in Stroke Mimics.

Journal Article Circ Cardiovasc Qual Outcomes · August 2019 BACKGROUND: The necessity for rapid evaluation and treatment of acute ischemic stroke with intravenous tPA (tissue-type plasminogen activator) may increase the risk of administrating tPA to patients presenting with noncerebrovascular conditions that closel ... Full text Link to item Cite

Association Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice.

Journal Article JAMA · July 16, 2019 IMPORTANCE: Randomized clinical trials suggest benefit of endovascular-reperfusion therapy for large vessel occlusion in acute ischemic stroke (AIS) is time dependent, but the extent to which it influences outcome and generalizability to routine clinical p ... Full text Open Access Link to item Cite

Medicare Shared Savings ACOs and Hospice Care for Ischemic Stroke Patients.

Journal Article J Am Geriatr Soc · July 2019 OBJECTIVES: Palliative care services have the potential to improve the quality of end-of-life care and reduce cost. Services such as the Medicare hospice benefit, however, are often underutilized among stroke patients with a poor prognosis. We tested the h ... Full text Link to item Cite

Thrombolysis in young adults with stroke: Findings from Get With The Guidelines-Stroke.

Journal Article Neurology · June 11, 2019 OBJECTIVE: To determine whether young adults (≤40 years old) with acute ischemic stroke are less likely to receive IV tissue plasminogen activator (tPA) and more likely to have longer times to brain imaging and treatment. METHODS: We analyzed data from the ... Full text Open Access Link to item Cite

Intravenous Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients With History of Stroke Plus Diabetes Mellitus.

Journal Article Stroke · June 2019 Background and Purpose- Acute ischemic stroke patients with history of prior ischemic stroke plus concomitant diabetes mellitus (DM) were excluded from the ECASS III trial (European Cooperative Acute Stroke Study) because of safety concerns. However, there ... Full text Link to item Cite

A paradoxical relationship between hemoglobin A1C and in-hospital mortality in intracerebral hemorrhage patients.

Journal Article Heliyon · May 2019 OBJECTIVES: The relationship between prior glycemic status and outcomes in intracerebral hemorrhage (ICH) is not established. We hypothesized that higher hemoglobin (Hb) A1c is associated with worse outcomes in ICH. PATIENTS AND METHODS: Using the GWTG-Str ... Full text Open Access Link to item Cite

Relation of Admission Blood Pressure to In-hospital and 90-Day Outcomes in Patients Presenting With Transient Ischemic Attack.

Journal Article Am J Cardiol · April 1, 2019 The association between admission blood pressure (BP) and outcomes in patients with transient ischemic attack (TIA) is not well defined. Patients in the United States national Get With The Guidelines-Stroke registry with a TIA were included. Admission syst ... Full text Link to item Cite

Comparison of Clinical Care and In-Hospital Outcomes of Asian American and White Patients With Acute Ischemic Stroke.

Journal Article JAMA Neurol · April 1, 2019 IMPORTANCE: Although overall stroke incidence and mortality in the United States is improving, little is known about the characteristics and clinical outcomes of acute ischemic stroke in Asian American individuals. OBJECTIVE: To compare the characteristics ... Full text Open Access Link to item Cite

Use, Temporal Trends, and Outcomes of Endovascular Therapy After Interhospital Transfer in the United States.

Journal Article Circulation · March 26, 2019 BACKGROUND: The use of endovascular therapy (EVT) in patients with acute ischemic stroke who have large vessel occlusion has rapidly increased in the United States following pivotal trials demonstrating its benefit. Information about the contribution of in ... Full text Link to item Cite

China's response to the rising stroke burden.

Journal Article BMJ · February 28, 2019 Zixiao Li and colleagues discuss why the number of strokes is growing in China and how the country is taking steps to reduce the rate and improve care ... Full text Open Access Link to item Cite

Correction to: The Need for Speed: Accelerating Quality of Care in Acute Ischemic Stroke

Journal Article Circulation: Cardiovascular Quality and Outcomes · February 2019 Full text Cite

Components and Trends in Door to Treatment Times for Endovascular Therapy in Get With The Guidelines-Stroke Hospitals.

Journal Article Circulation · January 8, 2019 BACKGROUND: Endovascular therapy (EVT) is standard of care in patients with acute disabling ischemic stroke attributable to large-vessel occlusion and is more effective when delivered quickly. It is currently unclear whether time targets achieved in clinic ... Full text Link to item Cite

An international cluster-randomized quality improvement trial to increase the adherence to evidence-based therapies for acute ischemic stroke and transient ischemic attack patients: Rationale and design of the BRIDGE STROKE Trial.

Journal Article Am Heart J · January 2019 BACKGROUND: Translating evidence into clinical practice in the management of acute ischemic stroke (AIS) and transient ischemic attack (TIA) is challenging especially in low- and middle-income countries. OBJECTIVES: The aim of this study is to assess the e ... Full text Link to item Cite

Prognostic Value of the PARIS Thrombotic Risk Score for 2-Year Mortality After Percutaneous Coronary Intervention.

Journal Article Clin Appl Thromb Hemost · 2019 The Patterns of non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) thrombotic risk score is a novel score for predicting the risk of coronary thrombotic events after percutaneous coronary intervention (PCI). We assessed the prognostic value ... Full text Open Access Link to item Cite

Chinese Stroke Center Alliance: a national effort to improve healthcare quality for acute stroke and transient ischaemic attack: rationale, design and preliminary findings.

Journal Article Stroke Vasc Neurol · December 2018 BACKGROUND: In June 2015, the Chinese Stroke Association (CSA) initiated the Chinese Stroke Center Alliance (CSCA) to establish the national hospital-based stroke care quality assessment and improvement platform. This article outlines its objectives, opera ... Full text Link to item Cite

Factors associated with 1-year mortality after discharge for acute stroke: what matters?

Journal Article Top Stroke Rehabil · December 2018 OBJECTIVE: To evaluate factors associated with 1-year mortality after discharge for acute stroke. METHODS: In this retrospective cohort study, we studied 305 patients with ischemic stroke or intracerebral hemorrhage discharged in 2010/2011. We linked Get W ... Full text Link to item Cite

Evidence-Based Performance Measures and Outcomes in Patients With Acute Ischemic Stroke.

Journal Article Circ Cardiovasc Qual Outcomes · December 2018 BACKGROUND: Stroke is the leading cause of death in China. Despite the wide dissemination of evidence-based guidelines, data about adherence to these in routine clinical practice are scarce. We conducted a study using a nationwide registry to evaluate the ... Full text Link to item Cite

Association of Kidney Function With 30-Day and 1-Year Poststroke Mortality and Hospital Readmission.

Journal Article Stroke · December 2018 Background and Purpose- Kidney dysfunction is common among patients hospitalized for ischemic stroke. Understanding the association of kidney disease with poststroke outcomes is important to properly adjust for case mix in outcome studies, payment models a ... Full text Link to item Cite

The Need for Speed.

Journal Article Circ Cardiovasc Qual Outcomes · December 2018 Full text Link to item Cite

Temperature and Precipitation Associate With Ischemic Stroke Outcomes in the United States.

Journal Article J Am Heart Assoc · November 20, 2018 Background There is disagreement in the literature about the relationship between strokes and seasonal conditions. We sought to (1) describe seasonal patterns of stroke in the United States, and (2) determine the relationship between weather variables and ... Full text Open Access Link to item Cite

International Comparison of Patient Characteristics and Quality of Care for Ischemic Stroke: Analysis of the China National Stroke Registry and the American Heart Association Get With The Guidelines--Stroke Program.

Journal Article J Am Heart Assoc · October 16, 2018 Background Adherence to evidence-based guidelines is an important quality indicator; yet, there is lack of assessment of adherence to performance measures in acute ischemic stroke for most world regions. Methods and Results We analyzed 19 604 patients with ... Full text Open Access Link to item Cite

Shock Index Predicts Patient-Related Clinical Outcomes in Stroke.

Journal Article J Am Heart Assoc · September 18, 2018 Background The prognostic value of shock index ( SI ), heart rate divided by systolic blood pressure, in stroke for clinical outcomes other than mortality is not well understood. Methods and Results We examined the Get With The Guidelines-Stroke ( GWTG -St ... Full text Open Access Link to item Cite

Intravenous tPA (Tissue-Type Plasminogen Activator) in Patients With Acute Ischemic Stroke Taking Non-Vitamin K Antagonist Oral Anticoagulants Preceding Stroke.

Journal Article Stroke · September 2018 Background and Purpose- Although there are no trials or large cohorts to inform clinical care, current guidelines caution against giving intravenous tPA (tissue-type plasminogen activator) to patients with acute ischemic stroke who are taking non-vitamin K ... Full text Link to item Cite

Rates, Characteristics, and Outcomes of Patients Transferred to Specialized Stroke Centers for Advanced Care.

Journal Article Circ Cardiovasc Qual Outcomes · September 2018 Background While many patients are transferred to specialized stroke centers for advanced acute ischemic stroke (AIS) care, few studies have characterized these patients. We sought to determine variation in the rates and differences in the baseline charact ... Full text Link to item Cite

Relationship between hospital performance measures and outcomes in patients with acute ischaemic stroke: a prospective cohort study.

Journal Article BMJ Open · August 1, 2018 OBJECTIVE: Evidence-based performance measures have been increasingly used to evaluate hospital quality of stroke care, but their impact on stroke outcomes has not been verified. We aimed to evaluate the correlations between hospital performance measures a ... Full text Open Access Link to item Cite

Effect of a Multifaceted Quality Improvement Intervention on Hospital Personnel Adherence to Performance Measures in Patients With Acute Ischemic Stroke in China: A Randomized Clinical Trial.

Journal Article JAMA · July 17, 2018 IMPORTANCE: In China and other parts of the world, hospital personnel adherence to evidence-based stroke care is limited. OBJECTIVE: To determine whether a multifaceted quality improvement intervention can improve hospital personnel adherence to evidence-b ... Full text Open Access Link to item Cite

Diabetes and long-term outcomes of ischaemic stroke: findings from Get With The Guidelines-Stroke.

Journal Article Eur Heart J · July 1, 2018 AIMS: There is a paucity of data on the influence of diabetes on long-term outcomes after ischaemic stroke (IS). We assessed whether outcomes after IS differ between patients with and without diabetes. METHODS AND RESULTS: Patients aged ≥65 years (n = 409  ... Full text Link to item Cite

The network of Shanghai Stroke Service System (4S): A public health-care web-based database using automatic extraction of electronic medical records.

Journal Article Int J Stroke · July 2018 Background Several stroke outcome and quality control projects have demonstrated the success in stroke care quality improvement through structured process. However, Chinese health-care systems are challenged with its overwhelming numbers of patients, limit ... Full text Link to item Cite

Comparison of Acute Ischemic Stroke Care and Outcomes Between Comprehensive Stroke Centers and Primary Stroke Centers in the United States.

Journal Article Circ Cardiovasc Qual Outcomes · June 2018 BACKGROUND: To improve stroke care, the Brain Attack Coalition recommended establishing primary stroke center (PSC) and comprehensive stroke center (CSC) certification. This study aimed to compare ischemic stroke care and in-hospital outcomes between CSCs ... Full text Link to item Cite

Prestroke and Poststroke Antithrombotic Therapy in Patients With Atrial Fibrillation: Results From a Nationwide Cohort.

Journal Article JAMA Netw Open · May 18, 2018 IMPORTANCE: Antithrombotic therapies are effective in both primary and secondary stroke prophylaxis in high-risk patients with atrial fibrillation (AF), but they are often underused in community practice. OBJECTIVE: To examine prestroke and poststroke anti ... Full text Link to item Cite

Single- Versus Multicenter Surgeons' Risk-Adjusted Coronary Artery Bypass Graft Procedural Outcomes.

Journal Article Ann Thorac Surg · May 2018 BACKGROUND: Since 2010, 460+ hospital mergers have occurred in the United States, rerouting historical coronary artery bypass graft (CABG) referral patterns. The goals of this study were: (1) to compare risk-adjusted CABG outcomes between single-center ver ... Full text Link to item Cite

The Society of Thoracic Surgeons 2018 Adult Cardiac Surgery Risk Models: Part 2-Statistical Methods and Results.

Journal Article Ann Thorac Surg · May 2018 BACKGROUND: The Society of Thoracic Surgeons (STS) uses statistical models to create risk-adjusted performance metrics for Adult Cardiac Surgery Database (ACSD) participants. Because of temporal changes in patient characteristics and outcomes, evolution of ... Full text Link to item Cite

Long-term Thromboembolic Risk in Patients With Postoperative Atrial Fibrillation After Coronary Artery Bypass Graft Surgery and Patients With Nonvalvular Atrial Fibrillation.

Journal Article JAMA Cardiol · May 1, 2018 IMPORTANCE: New-onset postoperative atrial fibrillation (POAF) is a common complication of coronary artery bypass graft (CABG) surgery. However, the long-term risk of thromboembolism in patients who develop POAF after CABG surgery remains unknown. In addit ... Full text Open Access Link to item Cite

[Predictive value of the GRACE discharge score on the long-term out-of-hospital coronary thrombotic events after implantation of drug-eluting stents].

Journal Article Zhonghua Xin Xue Guan Bing Za Zhi · March 24, 2018 Objective: To evaluate the predictive value of GRACE discharge score on the long-term out-of-hospital coronary thrombotic events (CTE) after percutaneous coronary intervention (PCI) with drug-eluting stents. Methods: Present study was a prospective, observ ... Full text Link to item Cite

Association of Intracerebral Hemorrhage Among Patients Taking Non-Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality.

Journal Article JAMA · February 6, 2018 IMPORTANCE: Although non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly used to prevent thromboembolic disease, there are limited data on NOAC-related intracerebral hemorrhage (ICH). OBJECTIVE: To assess the association between preceding ... Full text Open Access Link to item Cite

Evaluation of CRUSADE and ACUITY-HORIZONS Scores for Predicting Long-term Out-of-Hospital Bleeding after Percutaneous Coronary Interventions.

Journal Article Chin Med J (Engl) · February 5, 2018 BACKGROUND: There is scanty evidence concerning the ability of Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the ACC/AHA Guidelines (CRUSADE) and Acute Catheterization and Urgent Interventi ... Full text Open Access Link to item Cite

Absence of July Phenomenon in Acute Ischemic Stroke Care Quality and Outcomes.

Journal Article J Am Heart Assoc · January 31, 2018 BACKGROUND: Lower care quality and an increase in adverse outcomes as a result of new medical trainees is a concept well rooted in popular belief, termed the "July phenomenon." Whether this phenomenon occurs in acute ischemic stroke has not been well studi ... Full text Open Access Link to item Cite

Current Practice Trends for Use of Early Venous Thromboembolism Prophylaxis After Intracerebral Hemorrhage.

Journal Article Neurosurgery · January 1, 2018 BACKGROUND: Venous thromboembolism (VTE) is common after intracerebral hemorrhage (ICH). Guidelines recommend early VTE prophylaxis. OBJECTIVE: To determine characteristics associated with early chemoprophylaxis (CP) after ICH in the Get With The Guideline ... Full text Link to item Cite

Increase in Endovascular Therapy in Get With The Guidelines-Stroke After the Publication of Pivotal Trials.

Journal Article Circulation · December 12, 2017 BACKGROUND: Beginning in December 2014, a series of pivotal trials showed that endovascular thrombectomy (EVT) was highly effective, prompting calls to reorganize stroke systems of care. However, there are few data on how these trials influenced the freque ... Full text Link to item Cite

Could late measurement of serum creatinine be missed for patients without early increase in serum creatinine following coronary angiography?

Journal Article Medicine (Baltimore) · December 2017 Most patients are discharged early (within 24 hours) after coronary angiography (CAG) and may miss identification the late (24-48 hours) increase in serum creatinine (SCr), whose characteristics and prognosis have been less intensively investigated.We pros ... Full text Link to item Cite

Risk factors associated with 90-day recurrent stroke in patients on dual antiplatelet therapy for minor stroke or high-risk TIA: a subgroup analysis of the CHANCE trial.

Journal Article Stroke Vasc Neurol · December 2017 OBJECTIVE: Many patients receiving dual antiplatelet therapy still had recurrent strokes. We aimed to identify factors associated with recurrent stroke at 90 days in patients receiving dual antiplatelet therapy in Clopidogrel in High-risk patients with Acu ... Full text Link to item Cite

A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation (IMPACT-AF): an international, cluster-randomised trial.

Journal Article Lancet · October 14, 2017 BACKGROUND: Oral anticoagulation is underused in patients with atrial fibrillation. We assessed the impact of a multifaceted educational intervention, versus usual care, on oral anticoagulant use in patients with atrial fibrillation. METHODS: This study wa ... Full text Link to item Cite

Comparison of Transradial and Transfemoral Approaches in Women Undergoing Percutaneous Coronary Intervention in China: A Retrospective Observational Study.

Journal Article Angiology · October 2017 Despite increasing adoption of the transradial approach for percutaneous coronary intervention (PCI) in clinical practice, the role of transradial intervention (TRI) in women remains a significant debate. We identified 1392 women from a consecutive cohort ... Full text Link to item Cite

Unexplained Variation for Hospitals' Use of Inpatient Rehabilitation and Skilled Nursing Facilities After an Acute Ischemic Stroke.

Journal Article Stroke · October 2017 BACKGROUND AND PURPOSE: Rehabilitation is recommended after a stroke to enhance recovery and improve outcomes, but hospital's use of inpatient rehabilitation facilities (IRFs) or skilled nursing facility (SNF) and the factors associated with referral are u ... Full text Link to item Cite

Regional differences in presentation and antithrombotic treatment of patients with atrial fibrillation: Baseline characteristics from a clustered randomized trial to IMProve treatment with AntiCoagulanTs in patients with atrial fibrillation (IMPACT-AF).

Journal Article Am Heart J · October 2017 UNLABELLED: Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide. However, there are few contemporary comparative data on AF from middle-income countries. METHODS: Baseline characteristics of the IMPACT-AF trial were analyzed to asses ... Full text Link to item Cite

Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke.

Journal Article Eur Heart J · October 1, 2017 AIMS: Post-stroke hypertension is associated with poor short-term outcome, although the results have been conflicting. Our objective was to evaluate the association of blood pressure (BP) and in-hospital outcomes in patients with acute ischaemic stroke. ME ... Full text Link to item Cite

Is Risk-Standardized In-Hospital Stroke Mortality an Adequate Proxy for Risk-Standardized 30-Day Stroke Mortality Data? Findings From Get With The Guidelines-Stroke.

Journal Article Circ Cardiovasc Qual Outcomes · October 2017 BACKGROUND: Hospital profiling is typically undertaken using risk-standardized 30-day mortality, but obtaining these data for hospitals can be difficult. We sought to determine whether risk-standardized in-hospital mortality could serve as an adequate prox ... Full text Link to item Cite

Utilization, Characteristics, and In-Hospital Outcomes of Coronary Artery Bypass Grafting in Patients With ST-Segment-Elevation Myocardial Infarction: Results From the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines.

Journal Article Circ Cardiovasc Qual Outcomes · August 2017 BACKGROUND: There are limited data on the utilization and outcomes of coronary artery bypass grafting (CABG) among ST-segment-elevation myocardial infarction (STEMI) patients in contemporary practice. METHODS AND RESULTS: Using data from National Cardiovas ... Full text Link to item Cite

Regional Variation in 30-Day Ischemic Stroke Outcomes for Medicare Beneficiaries Treated in Get With The Guidelines-Stroke Hospitals.

Journal Article Circ Cardiovasc Qual Outcomes · August 2017 BACKGROUND: We explored regional variation in 30-day ischemic stroke mortality and readmission rates and the extent to which regional differences in patients, hospitals, healthcare resources, and a quality of care composite care measure explain the observe ... Full text Link to item Cite

Association of US Centers for Medicare and Medicaid Services Hospital 30-Day Risk-Standardized Readmission Metric With Care Quality and Outcomes After Acute Myocardial Infarction: Findings From the National Cardiovascular Data Registry/Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With the Guidelines.

Journal Article JAMA Cardiol · July 1, 2017 IMPORTANCE: The US Centers for Medicare and Medicaid Services Hospital Readmissions Reduction Program penalizes hospitals with higher-than-expected risk-adjusted 30-day readmission rates (excess readmission ratio [ERR] > 1) after acute myocardial infarctio ... Full text Link to item Cite

Association Between Previous Use of Antiplatelet Therapy and Intracerebral Hemorrhage Outcomes.

Journal Article Stroke · July 2017 BACKGROUND AND PURPOSE: Although the use of antiplatelet therapy (APT) is associated with the risk of intracerebral hemorrhage (ICH), there are limited data on prestroke APT and outcomes, particularly among patients on combination APT (CAPT). We hypothesiz ... Full text Link to item Cite

Early transition to comfort measures only in acute stroke patients: Analysis from the Get With The Guidelines-Stroke registry.

Journal Article Neurol Clin Pract · June 2017 BACKGROUND: Death after acute stroke often occurs after forgoing life-sustaining interventions. We sought to determine the patient and hospital characteristics associated with an early decision to transition to comfort measures only (CMO) after ischemic st ... Full text Link to item Cite

Direct Transport to a Percutaneous Cardiac Intervention Center and Outcomes in Patients With Out-of-Hospital Cardiac Arrest.

Journal Article Circ Cardiovasc Qual Outcomes · June 2017 BACKGROUND: Practice guidelines recommend regional systems of care for out-of-hospital cardiac arrest. However, whether emergency medical services should bypass nonpercutaneous cardiac intervention (non-PCI) facilities and transport out-of-hospital cardiac ... Full text Link to item Cite

Association of body mass index with mortality and functional outcome after acute ischemic stroke.

Journal Article Sci Rep · May 31, 2017 The relation between obesity and stroke outcome has been disputed. This study was aimed to determine the association of body mass index (BMI) with mortality and functional outcome in patients with acute ischemic stroke. Data were from a national, multi-cen ... Full text Open Access Link to item Cite

An Initial Evaluation of the Impact of Pokémon GO on Physical Activity.

Journal Article J Am Heart Assoc · May 16, 2017 BACKGROUND: Pokémon GO is a location-based augmented reality game. Using GPS and the camera on a smartphone, the game requires players to travel in real world to capture animated creatures, called Pokémon. We examined the impact of Pokémon GO on physical a ... Full text Open Access Link to item Cite

Sex and Age Interactions and Differences in Outcomes After Intracerebral Hemorrhage.

Journal Article J Womens Health (Larchmt) · April 2017 BACKGROUND: Compared to ischemic stroke, sex differences in response to intracerebral hemorrhage (ICH) are largely unexplored, and their potential interactions with patient age have not been examined. This study hypothesized that risk for poor outcome is g ... Full text Link to item Cite

Delays in Door-to-Needle Times and Their Impact on Treatment Time and Outcomes in Get With The Guidelines-Stroke.

Journal Article Stroke · April 2017 BACKGROUND AND PURPOSE: Despite quality improvement programs such as the American Heart Association/American Stroke Association Target Stroke initiative, a substantial portion of acute ischemic stroke patients are still treated with tissue-type plasminogen ... Full text Link to item Cite

Stroke care quality in China: Substantial improvement, and a huge challenge and opportunity.

Journal Article Int J Stroke · April 2017 Stroke is The first two authors contributed equally. the leading cause of death and adult disability in China. Although evidence-based clinical interventions have been identified to improve care and outcomes in stroke, significant gaps still exist between ... Full text Link to item Cite

Assessment and provision of rehabilitation among patients hospitalized with acute ischemic stroke in China: Findings from the China National Stroke Registry II.

Journal Article Int J Stroke · April 2017 Background Stroke rehabilitation improves functional recovery among stroke patients. However, little is known about clinical practice in China regarding the assessment and provision of rehabilitation among patients with acute ischemic stroke. Aims We exami ... Full text Link to item Cite

Use of Intravenous Recombinant Tissue Plasminogen Activator in Patients With Acute Ischemic Stroke Who Take Non-Vitamin K Antagonist Oral Anticoagulants Before Stroke.

Journal Article Circulation · March 14, 2017 BACKGROUND: Intravenous rt-PA (recombinant tissue-type plasminogen activator) is effective in improving outcomes in ischemic stroke; however, there are few data on the use of rt-PA in patients who are receiving a non-vitamin K antagonist oral anticoagulant ... Full text Link to item Cite

Association of Preceding Antithrombotic Treatment With Acute Ischemic Stroke Severity and In-Hospital Outcomes Among Patients With Atrial Fibrillation.

Journal Article JAMA · March 14, 2017 IMPORTANCE: Antithrombotic therapies are known to prevent stroke for patients with atrial fibrillation (AF) but are often underused in community practice. OBJECTIVES: To examine the prevalence of patients with acute ischemic stroke with known history of AF ... Full text Open Access Link to item Cite

Coexistent Sickle Cell Disease Has No Impact on the Safety or Outcome of Lytic Therapy in Acute Ischemic Stroke: Findings From Get With The Guidelines-Stroke.

Journal Article Stroke · March 2017 BACKGROUND AND PURPOSE: The recommended treatment for ischemic stroke is tPA (tissue-type plasminogen activator). Although sickle cell disease (SCD) represents no known contraindication to tPA, National Heart Lung and Blood Institute of the National Instit ... Full text Link to item Cite

Timely Reperfusion in Stroke and Myocardial Infarction Is Not Correlated: An Opportunity for Better Coordination of Acute Care.

Journal Article Circ Cardiovasc Qual Outcomes · March 2017 BACKGROUND: Timely reperfusion is critical in acute ischemic stroke (AIS) and ST-segment-elevation myocardial infarction (STEMI). The degree to which hospital performance is correlated on emergent STEMI and AIS care is unknown. Primary objective of this st ... Full text Link to item Cite

Renal Dysfunction Is Associated With Poststroke Discharge Disposition and In-Hospital Mortality: Findings From Get With The Guidelines-Stroke.

Journal Article Stroke · February 2017 BACKGROUND AND PURPOSE: Kidney disease is a frequent comorbidity in patients presenting with acute ischemic stroke. We evaluated whether the estimated glomerular filtration rate (eGFR) on admission is associated with poststroke in-hospital mortality or dis ... Full text Link to item Cite

Differences in Acute Ischemic Stroke Quality of Care and Outcomes by Primary Stroke Center Certification Organization.

Journal Article Stroke · February 2017 BACKGROUND AND PURPOSE: Primary stroke center (PSC) certification was established to identify hospitals providing evidence-based care for stroke patients. The numbers of PSCs certified by Joint Commission (JC), Healthcare Facilities Accreditation Program, ... Full text Link to item Cite

Hospital Variation in Functional Recovery After Stroke.

Journal Article Circ Cardiovasc Qual Outcomes · January 2017 BACKGROUND: Functional status is a key patient-centric outcome, but there are little data on whether functional recovery post-stroke varies among hospitals. This study examined the distribution of functional status 3 months after stroke, determined whether ... Full text Link to item Cite

Use of Strategies to Improve Door-to-Needle Times With Tissue-Type Plasminogen Activator in Acute Ischemic Stroke in Clinical Practice: Findings from Target: Stroke.

Journal Article Circ Cardiovasc Qual Outcomes · January 2017 BACKGROUND: The implementation of Target: Stroke Phase I, the first stage of the American Heart Association's national quality improvement initiative to accelerate door-to-needle (DTN) times, was associated with an average 15-minute reduction in DTN times. ... Full text Link to item Cite

Acute management of stroke patients taking non-vitamin K antagonist oral anticoagulants Addressing Real-world Anticoagulant Management Issues in Stroke (ARAMIS) Registry: Design and rationale.

Journal Article Am Heart J · December 2016 BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs, dabigatran, rivaroxaban, apixaban, and edoxaban) have been increasingly used as alternatives to warfarin for stroke prophylaxis in patients with atrial fibrillation. Yet there is substantial ... Full text Link to item Cite

Obesity is associated with better survival and functional outcome after acute intracerebral hemorrhage.

Journal Article J Neurol Sci · November 15, 2016 OBJECTIVE: To evaluate the association of obesity measured by body mass index (BMI) with mortality and functional outcome in patients with acute intracerebral hemorrhage (ICH). METHODS: Data were from 1571 patients with ICH enrolled in a national, multi-ce ... Full text Link to item Cite

Impact of Insurance Status on Outcomes and Use of Rehabilitation Services in Acute Ischemic Stroke: Findings From Get With The Guidelines-Stroke.

Journal Article J Am Heart Assoc · November 14, 2016 BACKGROUND: Insurance status affects access to care, which may affect health outcomes. The objective was to determine whether patients without insurance or with government-sponsored insurance had worse quality of care or in-hospital outcomes in acute ische ... Full text Open Access Link to item Cite

Substantial Progress Yet Significant Opportunity for Improvement in Stroke Care in China.

Journal Article Stroke · November 2016 BACKGROUND AND PURPOSE: Stroke is a leading cause of death in China. Yet the adherence to guideline-recommended ischemic stroke performance metrics in the past decade has been previously shown to be suboptimal. Since then, several nationwide stroke quality ... Full text Link to item Cite

Hospital Variation in Home-Time After Acute Ischemic Stroke: Insights From the PROSPER Study (Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research).

Journal Article Stroke · October 2016 BACKGROUND AND PURPOSE: Stroke survivors identify home-time as a high-priority outcome; there are limited data on factors influencing home-time and home-time variability among discharging hospitals. METHODS: We ascertained home-time (ie, time alive out of ... Full text Link to item Cite

Comparing Inverse Probability of Treatment Weighting and Instrumental Variable Methods for the Evaluation of Adenosine Diphosphate Receptor Inhibitors After Percutaneous Coronary Intervention.

Journal Article JAMA Cardiol · September 1, 2016 IMPORTANCE: There is increasing interest in performing comparative effectiveness analyses in large observational databases, yet these analyses must adjust for treatment selection issues. OBJECTIVES: To conduct comparative safety and efficacy analyses of pr ... Full text Open Access Link to item Cite

Use and Outcomes of Intravenous Thrombolysis for Acute Ischemic Stroke in Patients ≥90 Years of Age.

Journal Article Stroke · September 2016 BACKGROUND AND PURPOSE: Intravenous tissue-type plasminogen activator (tPA) is a proven treatment for acute ischemic stroke, but there has been limited evaluation among patients aged ≥90 years. METHODS: We analyzed data from the Get With The Guidelines-Str ... Full text Link to item Cite

Failure to Rescue Rates After Coronary Artery Bypass Grafting: An Analysis From The Society of Thoracic Surgeons Adult Cardiac Surgery Database.

Journal Article Ann Thorac Surg · August 2016 BACKGROUND: Failure to rescue (FTR) is increasingly recognized as an important quality indicator in surgery. The Society of Thoracic Surgeons National Database was used to develop FTR metrics and a predictive FTR model for coronary artery bypass grafting ( ... Full text Link to item Cite

Prior Antithrombotic Use Is Associated With Favorable Mortality and Functional Outcomes in Acute Ischemic Stroke.

Journal Article Stroke · August 2016 BACKGROUND AND PURPOSE: Antithrombotics are the mainstay of treatment in primary and secondary prevention of stroke, and their use before an acute event may be associated with better outcomes. METHODS: Using data from Get With The Guidelines-Stroke with ov ... Full text Link to item Cite

Coronary Artery Bypass Graft Surgery and Percutaneous Coronary Interventions in Patients With Unprotected Left Main Coronary Artery Disease.

Journal Article JACC Cardiovasc Interv · June 13, 2016 OBJECTIVES: This study sought to investigate long-term clinical outcomes following coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) in patients with unprotected left main disease (ULMD). BACKGROUND: PCI has been increasingly ... Full text Link to item Cite

A clustered randomized trial to IMProve treatment with AntiCoagulanTs in patients with Atrial Fibrillation (IMPACT-AF): design and rationale.

Journal Article Am Heart J · June 2016 Atrial fibrillation (AF) is common, increasing as the population ages, and a major cause of embolic stroke. While oral anticoagulation (OAC) is highly effective at preventing stroke in patients with AF, it continues to be underused in eligible patients wor ... Full text Link to item Cite

The China Acute Myocardial Infarction (CAMI) Registry: A national long-term registry-research-education integrated platform for exploring acute myocardial infarction in China.

Journal Article Am Heart J · May 2016 BACKGROUND: Acute myocardial infarction (AMI) has become a major cause of hospitalization and mortality in China. There has been limited data to date available to characterize AMI presentation, contemporary patterns of medical care, and outcomes in China. ... Full text Link to item Cite

Intravenous adenosine in termination of paroxysmal supraventricular tachycardia

Journal Article Chin J New Drugs Clin Rem · May 1, 2016 Cite

Costs and Benefits Associated With Transradial Versus Transfemoral Percutaneous Coronary Intervention in China.

Journal Article J Am Heart Assoc · April 22, 2016 BACKGROUND: Transradial percutaneous coronary intervention (PCI) has been increasingly adopted in clinical practice, given its potential advantages over transfemoral intervention; however, the impact of different access strategies on costs and clinical out ... Full text Open Access Link to item Cite

Treatment Effect of Clopidogrel Plus Aspirin Within 12 Hours of Acute Minor Stroke or Transient Ischemic Attack.

Journal Article J Am Heart Assoc · March 21, 2016 BACKGROUND: The aim of this study was to analyze the benefits and safety associated with the combination therapy of clopidogrel and aspirin among minor stroke or transient ischemic attack patients treated within 12 hours. METHODS AND RESULTS: This was a su ... Full text Open Access Link to item Cite

Assessment of Home-Time After Acute Ischemic Stroke in Medicare Beneficiaries.

Journal Article Stroke · March 2016 BACKGROUND AND PURPOSE: Stroke survivors have identified home-time as a meaningful outcome. We evaluated home-time as a patient-centered outcome in Medicare beneficiaries with ischemic stroke in comparison with modified Rankin Scale (mRS) score at 90 days ... Full text Link to item Cite

Aggressive hydraTion in patients with ST-Elevation Myocardial infarction undergoing Primary percutaneous coronary intervention to prevenT contrast-induced nephropathy (ATTEMPT): Study design and protocol for the randomized, controlled trial, the ATTEMPT, RESCIND 1 (First study for REduction of contraSt-induCed nephropathy followINg carDiac catheterization) trial.

Journal Article Am Heart J · February 2016 Adequate hydration is recommended for acute ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) to prevent contrast-induced nephropathy (CIN). However, the optimal hydration regimen has not been w ... Full text Link to item Cite

Risks and Benefits Associated With Prestroke Antiplatelet Therapy Among Patients With Acute Ischemic Stroke Treated With Intravenous Tissue Plasminogen Activator.

Journal Article JAMA Neurol · January 2016 IMPORTANCE: Intravenous tissue plasminogen activator (tPA) is known to improve outcomes in ischemic stroke; however, many patients may have been receiving antiplatelet therapy before acute ischemic stroke and could face an increased risk for bleeding when ... Full text Open Access Link to item Cite

The Comparison of the Outcomes between Primary PCI, Fibrinolysis, and No Reperfusion in Patients ≥ 75 Years Old with ST-Segment Elevation Myocardial Infarction: Results from the Chinese Acute Myocardial Infarction (CAMI) Registry.

Journal Article PLoS One · 2016 BACKGROUND: Only a few randomized trials have analyzed the clinical outcomes of elderly ST-segment elevation myocardial infarction (STEMI) patients (≥ 75 years old). Therefore, the best reperfusion strategy has not been well established. An observational s ... Full text Open Access Link to item Cite

Relationship Between the Urine Flow Rate and Risk of Contrast-Induced Nephropathy After Emergent Percutaneous Coronary Intervention.

Journal Article Medicine (Baltimore) · December 2015 A low urine flow rate is a marker of acute kidney injury. However, it is unclear whether a high urine flow rate is associated with a reduced risk of contrast-induced nephropathy (CIN) in high-risk patients. We conducted this study to evaluate the predictiv ... Full text Link to item Cite

Clinical Effectiveness of Statin Therapy After Ischemic Stroke: Primary Results From the Statin Therapeutic Area of the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study.

Journal Article Circulation · October 13, 2015 BACKGROUND: In patients with ischemic stroke, data on the real-world effectiveness of statin therapy for clinical and patient-centered outcomes are needed to better inform shared decision making. METHODS AND RESULTS: Patient-Centered Research Into Outcomes ... Full text Link to item Cite

Smoking Paradox in Patients Hospitalized With Coronary Artery Disease or Acute Ischemic Stroke: Findings From Get With The Guidelines.

Journal Article Circ Cardiovasc Qual Outcomes · October 2015 BACKGROUND: Smoking is a potent risk factor for coronary artery disease (CAD) and acute ischemic stroke (AIS), but there are numerous reports of lower in-hospital mortality among smokers versus nonsmokers hospitalized for these events. METHODS AND RESULTS: ... Full text Link to item Cite

Quality of Care and Ischemic Stroke Risk After Hospitalization for Transient Ischemic Attack: Findings From Get With The Guidelines-Stroke.

Journal Article Circ Cardiovasc Qual Outcomes · October 2015 BACKGROUND: Patients with transient ischemic attack (TIA) are at increased risk for ischemic stroke. We derived a prediction rule for 1-year ischemic stroke risk post-TIA, examining estimated risk, receipt of inpatient quality of care measures for TIA, and ... Full text Link to item Cite

Research without borders: fostering innovative clinical research and implementation.

Journal Article Neurol Res · September 2015 Stroke remains one of the major killers worldwide. Addressing this epidemic will require combined efforts of researchers (bench, translational, clinical, epidemiologists, outcomes, and implementation scientists) as well as all forms of health care workers ... Full text Link to item Cite

Effect of clopidogrel with aspirin on functional outcome in TIA or minor stroke: CHANCE substudy.

Journal Article Neurology · August 18, 2015 OBJECTIVE: We compared the effect of clopidogrel plus aspirin vs aspirin alone on functional outcome and quality of life in the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial of aspirin-clopidogrel vs aspir ... Full text Link to item Cite

Racial/Ethnic and Sex Differences in Emergency Medical Services Transport Among Hospitalized US Stroke Patients: Analysis of the National Get With The Guidelines-Stroke Registry.

Journal Article J Am Heart Assoc · August 12, 2015 BACKGROUND: Differences in activation of emergency medical services (EMS) may contribute to racial/ethnic and sex disparities in stroke outcomes. The purpose of this study was to determine whether EMS use varied by race/ethnicity and sex among a current, d ... Full text Open Access Link to item Cite

Comparative Effectiveness of Hybrid Coronary Revascularization vs Coronary Artery Bypass Grafting.

Journal Article J Am Coll Surg · August 2015 BACKGROUND: Hybrid coronary revascularization (HCR) combines minimally invasive left internal mammary artery to left anterior descending bypass with percutaneous coronary intervention of non-left anterior descending vessels. Its safety and effectiveness co ... Full text Link to item Cite

Real world effectiveness of warfarin among ischemic stroke patients with atrial fibrillation: observational analysis from Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) study.

Journal Article BMJ · July 31, 2015 OBJECTIVE: To examine the association between warfarin treatment and longitudinal outcomes after ischemic stroke in patients with atrial fibrillation in community practice. DESIGN: Observational study. SETTING: Hospitals (n = 1487) participating in the Get ... Full text Open Access Link to item Cite

Association of Discharge Aspirin Dose With Outcomes After Acute Myocardial Infarction: Insights From the Treatment with ADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) Study.

Conference Circulation · July 21, 2015 BACKGROUND: Aspirin is the most widely used antiplatelet drug postmyocardial infarction, yet its optimal maintenance dose after percutaneous coronary intervention with stenting remains uncertain. METHODS AND RESULTS: We compared outcomes of 10 213 patients ... Full text Link to item Cite

Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research: Implementing the patient-driven research paradigm to aid decision making in stroke care.

Journal Article Am Heart J · July 2015 BACKGROUND: Stroke is common and costly, annually depriving the lives and well-being of 800,000 Americans. Despite demonstrated efficacy in clinical trials, questions remain about the safety and clinical effectiveness of various treatment options given pat ... Full text Link to item Cite

Novel Oral Anticoagulant Use Among Patients With Atrial Fibrillation Hospitalized With Ischemic Stroke or Transient Ischemic Attack.

Journal Article Circ Cardiovasc Qual Outcomes · July 2015 BACKGROUND: Novel oral anticoagulants (NOACs) have been shown to be at least as good as warfarin for preventing stroke or transient ischemic attack in patients with atrial fibrillation, yet diffusion of these therapies and patterns of use among atrial fibr ... Full text Link to item Cite

Rationale and design of a cluster-randomized multifaceted intervention trial to improve stroke care quality in China: The GOLDEN BRIDGE-Acute Ischemic Stroke.

Journal Article Am Heart J · June 2015 BACKGROUND: Prior studies have demonstrated a significant gap between guideline-based recommendations and clinical practice in the management of acute ischemic stroke (AIS) in China. AIMS: This study implements a targeted multifaceted quality improvement i ... Full text Link to item Cite

Lack of impact of electronic health records on quality of care and outcomes for ischemic stroke.

Journal Article J Am Coll Cardiol · May 12, 2015 BACKGROUND: Electronic health records (EHRs) may be key tools for improving the quality of health care, particularly for conditions for which guidelines are rapidly evolving and timely care is critical, such as ischemic stroke. OBJECTIVES: The goal of this ... Full text Link to item Cite

A nationwide survey on perception, experience, and expectations of hybrid coronary revascularization among top-ranked US hospitals.

Journal Article Am Heart J · April 2015 BACKGROUND: Hybrid coronary revascularization (HCR) combines a surgical and percutaneous approach for treatment of multivessel coronary artery disease. METHODS: A survey was conducted among 200 cardiologists and cardiac surgeons from 100 top-ranked US hosp ... Full text Link to item Cite

Trends in endovascular therapy and clinical outcomes within the nationwide Get With The Guidelines-Stroke registry.

Journal Article Stroke · April 2015 BACKGROUND AND PURPOSE: We sought to determine hospital and patient characteristics associated with the use of endovascular therapy for acute ischemic stroke and to analyze trends in clinical outcome. METHODS: Data were from Get With The Guidelines-Stroke ... Full text Link to item Cite

Seroprevalence ofToxoplasma gondiiInfection in Patients of Intensive Care Unit in China: A Hospital Based Study

Journal Article BioMed Research International · 2015 The objective of this study was to estimate the seroprevalence ofToxoplasma gondiiinfection in 394 patients of intensive care unit (ICU) in a hospital between April 2010 and March 2012 and analyze the association between< ... Full text Cite

Hospital case volume is associated with mortality in patients hospitalized with subarachnoid hemorrhage.

Journal Article Neurosurgery · November 2014 BACKGROUND: Prior studies have suggested that hospital case volume may be associated with improved outcomes after subarachnoid hemorrhage (SAH), but contemporary national data are limited. OBJECTIVE: To assess the association between hospital case volume f ... Full text Link to item Cite

Association between estimated glomerular filtration rate and clinical outcomes in patients with acute ischaemic stroke: results from China National Stroke Registry.

Journal Article Age Ageing · November 2014 BACKGROUND: the impact of estimated glomerular filtration rate (eGFR) on stroke clinical outcomes remains controversial. We examined the association between eGFR and all-cause mortality, recurrent stroke, and stroke disability in patients with acute ischae ... Full text Link to item Cite

Racial/Ethnic differences in process of care and outcomes among patients hospitalized with intracerebral hemorrhage.

Journal Article Stroke · November 2014 BACKGROUND AND PURPOSE: Although racial/ethnic differences in care are pervasive in many areas of medicine, little is known whether intracerebral hemorrhage (ICH) care processes or outcomes differ by race/ethnicity. METHODS: We analyzed 123 623 patients wi ... Full text Link to item Cite

Clinical outcomes of hybrid coronary revascularization versus coronary artery bypass surgery in patients with diabetes mellitus.

Journal Article Am Heart J · October 2014 BACKGROUND: Hybrid coronary revascularization (HCR) involves minimally invasive left internal mammary artery to left anterior descending coronary artery grafting combined with percutaneous coronary intervention (PCI) of non-left anterior descending vessels ... Full text Link to item Cite

Practice patterns and clinical outcomes after hybrid coronary revascularization in the United States: an analysis from the society of thoracic surgeons adult cardiac database.

Journal Article Circulation · September 9, 2014 BACKGROUND: Hybrid coronary revascularization (HCR) involves a combination of surgical and percutaneous techniques, which in selected patients may present an alternative to conventional coronary artery bypass grafting (CABG). METHODS AND RESULTS: Patients ... Full text Link to item Cite

Race/Ethnic differences in the risk of hemorrhagic complications among patients with ischemic stroke receiving thrombolytic therapy.

Journal Article Stroke · August 2014 BACKGROUND AND PURPOSE: Race/ethnic-related differences in safety of intravenous thrombolytic therapy have been shown in patients with myocardial infarction, but not studied in ischemic stroke. METHODS: Using data from the Get With The Guidelines (GWTG)-St ... Full text Link to item Cite

Strategies used by hospitals to improve speed of tissue-type plasminogen activator treatment in acute ischemic stroke.

Journal Article Stroke · May 2014 BACKGROUND AND PURPOSE: The benefits of intravenous tissue-type plasminogen activator in acute ischemic stroke are time dependent, and several strategies have been reported to be associated with more rapid door-to-needle (DTN) times. However, the extent to ... Full text Link to item Cite

Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative.

Journal Article JAMA · April 23, 2014 IMPORTANCE: The benefits of intravenous tissue plasminogen activator (tPA) in patients with acute ischemic stroke (AIS) are time dependent and guidelines recommend a door-to-needle (DTN) time of 60 minutes or less. However, studies have found that less tha ... Full text Link to item Cite

Will Nintendo "Wii Fit" Get You Fit? An Evaluation of the Energy Expenditure from Active-Play Videogames.

Journal Article Games Health J · April 2014 OBJECTIVE: This study aimed to determine whether Nintendo(®) (Redmond, WA) "Wii Fit™" games can help individuals meet physical activity recommendations. SUBJECTS AND METHODS: Thirty young healthy volunteers were recruited for this randomized crossover stud ... Full text Link to item Cite

Sources of hospital-level variation in major bleeding among patients with non-st-segment elevation myocardial infarction: a report from the National Cardiovascular Data Registry (NCDR).

Journal Article Circ Cardiovasc Qual Outcomes · March 2014 BACKGROUND: Major bleeding has received increasing attention as a target for quality improvement in care of patients with acute myocardial infarction. However, little is known about variation in bleeding across hospitals and whether variation is attributab ... Full text Link to item Cite

Quality of care and outcomes for in-hospital ischemic stroke: findings from the National Get With The Guidelines-Stroke.

Journal Article Stroke · January 2014 BACKGROUND AND PURPOSE: Analysis of quality of care for in-hospital stroke has not been previously performed at the national level. This study compares patient characteristics, process measures of quality, and outcomes for in-hospital strokes with those fo ... Full text Link to item Cite

Status quo of hybrid coronary revascularization for multi-vessel coronary artery disease.

Journal Article Ann Thorac Surg · December 2013 Hybrid coronary revascularization (HCR) combines bypass grafting of the left anterior descending (LAD) coronary artery with percutaneous coronary intervention (PCI) of non-LAD vessels. HCR has been performed as an alternative to CABG or multi-vessel PCI in ... Full text Link to item Cite

Relationship between sex, ejection fraction, and B-type natriuretic peptide levels in patients hospitalized with heart failure and associations with inhospital outcomes: findings from the Get With The Guideline-Heart Failure Registry.

Journal Article Am Heart J · December 2013 BACKGROUND: In heart failure (HF), there are known differences in plasma B-type natriuretic peptide (BNP) levels between reduced and preserved ejection fraction (EF), but few HF studies have explored sex differences. We sought to evaluate the relationship ... Full text Link to item Cite

The association between smoking and long-term outcomes after non-ST-segment elevation myocardial infarction in older patients.

Journal Article Am Heart J · December 2013 BACKGROUND: Prior studies have observed that smokers have paradoxically favorable 1-year mortality rates after acute coronary syndromes, but it is unknown whether this association extends to long-term outcomes and to older patients. METHODS: We identified ... Full text Link to item Cite

Comparison of performance achievement award recognition with primary stroke center certification for acute ischemic stroke care.

Journal Article J Am Heart Assoc · October 14, 2013 BACKGROUND: Hospital certification and recognition programs represent 2 independent but commonly used systems to distinguish hospitals, yet they have not been directly compared. This study assessed acute ischemic stroke quality of care measure conformity b ... Full text Open Access Link to item Cite

Patterns of emergency medical services use and its association with timely stroke treatment: findings from Get With the Guidelines-Stroke.

Journal Article Circ Cardiovasc Qual Outcomes · May 1, 2013 BACKGROUND: Prior studies found that only about half of stroke patients arrived at hospitals via emergency medical services (EMSs), yet since then, there have been efforts to increase public awareness that time is brain. Using contemporary Get With the Gui ... Full text Link to item Cite

Targeting telestroke: benchmarking time performance in telestroke consultations.

Journal Article J Stroke Cerebrovasc Dis · May 2013 OBJECTIVE: To describe the length of time physicians spend completing telestroke consultations and examine factors associated with that period. METHODS: This is a retrospective review of data from telestroke software. Clinical data obtained between July 20 ... Full text Link to item Cite

Racial and ethnic differences in outcomes in older patients with acute ischemic stroke.

Journal Article Circ Cardiovasc Qual Outcomes · May 1, 2013 BACKGROUND: Little is known as to whether long-term outcomes of acute ischemic stroke (AIS) vary by race/ethnicity. Using the American Heart Association Get With The Guidelines-Stroke registry linked with Medicare claims data set, we examined whether 30-da ... Full text Link to item Cite

The impact of a statewide pre-hospital STEMI strategy to bypass hospitals without percutaneous coronary intervention capability on treatment times.

Journal Article Circulation · February 5, 2013 BACKGROUND: The ultimate treatment goal for ST-segment elevation myocardial infarction (STEMI) is rapid reperfusion via primary percutaneous intervention (PCI). North Carolina has adopted a statewide STEMI referral strategy that advises paramedics to bypas ... Full text Link to item Cite

Data sources for heart failure comparative effectiveness research.

Journal Article Heart Fail Clin · January 2013 Existing data sources for heart failure research offer advantages and disadvantages for CER. Clinical registries collect detailed information about disease presentation, treatment, and outcomes on a large number of patients and provide the "real-world" pop ... Full text Link to item Cite

JSSlicer: A Static Program Slicing Tool for JavaScript

Conference Applied Mechanics and Materials · December 2012 The rapid development of Web 2.0 leads scripting language such as JavaScript to be ubiquitous in web pages; however the dynamic nature and flexibility of JavaScript make its development, debugging, maintenance, and reuse difficult. To improve the e ... Full text Cite

Patterns, predictors, variations, and temporal trends in emergency medical service hospital prenotification for acute ischemic stroke.

Journal Article J Am Heart Assoc · August 2012 BACKGROUND#ENTITYSTARTX02014;: Emergency medical services (EMS) hospital prenotification of an incoming stroke patient is guideline recommended as a means of increasing the timeliness with which stroke patients are evaluated and treated. Still, data are li ... Full text Open Access Link to item Cite

Emergency medical service hospital prenotification is associated with improved evaluation and treatment of acute ischemic stroke.

Journal Article Circ Cardiovasc Qual Outcomes · July 1, 2012 BACKGROUND: The benefits of intravenous tissue-plasminogen activator (tPA) in acute ischemic stroke are time-dependent. Emergency medical services (EMS) hospital prenotification of an incoming patient with potential stroke may provide a means of reducing e ... Full text Link to item Cite

Risks of intracranial hemorrhage among patients with acute ischemic stroke receiving warfarin and treated with intravenous tissue plasminogen activator.

Journal Article JAMA · June 27, 2012 CONTEXT: Intravenous tissue plasminogen activator (tPA) is known to improve outcomes in ischemic stroke; however, patients receiving long-term chronic warfarin therapy may face an increased risk for intracranial hemorrhage when treated with tPA. Although c ... Full text Open Access Link to item Cite

Challenges in assessing hospital-level stroke mortality as a quality measure: comparison of ischemic, intracerebral hemorrhage, and total stroke mortality rates.

Journal Article Stroke · June 2012 BACKGROUND AND PURPOSE: Public reporting efforts currently profile hospitals based on overall stroke mortality rates, yet the "mix" of hemorrhagic and ischemic stroke cases may impact this rate. METHODS: Using the 2005 to 2006 New York state data, we exami ... Full text Link to item Cite

Temporal trends in and factors associated with bleeding complications among patients undergoing percutaneous coronary intervention: a report from the National Cardiovascular Data CathPCI Registry.

Journal Article J Am Coll Cardiol · May 22, 2012 OBJECTIVES: The purpose of this study was to examine temporal trends in post-percutaneous coronary intervention (PCI) bleeding among patients with elective PCI, unstable angina (UA)/non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment el ... Full text Link to item Cite

Data quality in the American Heart Association Get With The Guidelines-Stroke (GWTG-Stroke): results from a national data validation audit.

Journal Article Am Heart J · March 2012 BACKGROUND: Get With The Guidelines (GWTG)-Stroke is a national stroke registry and quality improvement program. We examined the accuracy and reliability of data entered in GWTG-Stroke. METHODS: Data entered by sites in the GWTG-Stroke database were compar ... Full text Link to item Cite

Racial differences in mortality among patients with acute ischemic stroke: an observational study.

Journal Article Ann Intern Med · February 1, 2011 BACKGROUND: Black patients are commonly believed to have higher stroke mortality. However, several recent studies have reported better survival in black patients with stroke. OBJECTIVE: To examine racial differences in stroke mortality and explore potentia ... Full text Link to item Cite

Association between stroke center hospitalization for acute ischemic stroke and mortality.

Journal Article JAMA · January 26, 2011 CONTEXT: Although stroke centers are widely accepted and supported, little is known about their effect on patient outcomes. OBJECTIVE: To examine the association between admission to stroke centers for acute ischemic stroke and mortality. DESIGN, SETTING, ... Full text Open Access Link to item Cite

Are quality improvements associated with the Get With the Guidelines-Coronary Artery Disease (GWTG-CAD) program sustained over time? A longitudinal comparison of GWTG-CAD hospitals versus non-GWTG-CAD hospitals.

Journal Article Am Heart J · February 2010 BACKGROUND: Previous reports have demonstrated that participation in GWTG-CAD, a national quality initiative of the American Heart Association, is associated with improved guideline adherence for patients hospitalized with CAD. We sought to establish wheth ... Full text Link to item Cite

P104 The impact of a new cancer diagnosis on vulnerability in older Medicare beneficiaries

Conference Critical Reviews in Oncology/Hematology · October 2009 Full text Cite

Association of a cancer diagnosis with vulnerability and frailty in older Medicare beneficiaries.

Journal Article J Natl Cancer Inst · September 2, 2009 BACKGROUND: Few studies have evaluated the independent effect of a cancer diagnosis on vulnerability and frailty, which have been associated with adverse health outcomes in older adults. METHODS: We used data in the 2003 Medicare Current Beneficiary Survey ... Full text Link to item Cite

The impact of cancer on vulnerability in older Medicare beneficiaries

Conference Journal of Clinical Oncology · May 20, 2008 Full text Cite

A Comparative Study to Extract the Diaphragmatic Electromyogram Signal

Conference 2008 International Conference on BioMedical Engineering and Informatics · May 2008 Full text Cite