Journal ArticleViruses · March 2024
Avian influenza viruses (AIVs) have posed a significant pandemic threat since their discovery. This review mainly focuses on the epidemiology, virology, pathogenesis, and treatments of avian influenza viruses. We delve into the global spread, past pandemic ...
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Journal ArticleClinical & translational immunology · January 2020
ObjectivesLittle is known about the prevalence of febrile illness in the Arabian region as clinical, laboratory and immunological profiling remains largely uncharacterised.MethodsA total of 2018 febrile patients from Jazan, Saudi Arabia, ...
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Journal ArticleThe Journal of infectious diseases · June 2019
BackgroundZika virus (ZIKV) infections have reemerged as a global health issue due to serious clinical complications. Development of specific serological assays to detect and differentiate ZIKV from other cocirculating flaviviruses for accurate di ...
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Journal ArticleClinical & translational immunology · January 2019
ObjectivesRecent Zika virus (ZIKV) outbreaks challenged existing laboratory diagnostic standards, especially for serology-based methods. Because of the genetic and structural similarity of ZIKV with other flaviviruses, this results in cross-reacti ...
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Journal ArticleScientific reports · November 2018
Animal models that recapitulate the human pathophysiology have been developed as useful research tools. Although laboratory mice are widely used, they are phylogenetically "distant" to humans. New world monkeys, such as the common marmoset (Callithrix jacc ...
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Journal ArticleJournal of the peripheral nervous system : JPNS · September 2018
Although individuals with Zika virus (ZIKV) antibodies were reported in Malaya in mid-1950s, entomological and human surveillance in Singapore did not identify autochthonous transmission until the outbreak of August-November, 2016. A total of 455 cases fro ...
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Journal ArticleThe Journal of infectious diseases · July 2018
BackgroundSince its unexpected reemergence, Zika virus (ZIKV) has caused numerous outbreaks globally. This study characterized the host immune responses during ZIKV infection.MethodsPatient samples were collected longitudinally during the ...
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Journal ArticleScientific reports · March 2018
Infection with Zika virus (ZIKV), a mosquito-borne flavivirus has been casually linked with increased congenital microcephaly in Brazil from 2015 through 2016. Sensitive and specific diagnosis of patients with Zika fever (ZIKF) remains critical for patient ...
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Journal ArticleScientific reports · January 2018
The arthropod-transmitted chikungunya virus (CHIKV) causes a flu-like disease that is characterized by incapacitating arthralgia. The re-emergence of CHIKV and the continual risk of new epidemics have reignited research in CHIKV pathogenesis. Virus-specifi ...
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Journal ArticlePLoS neglected tropical diseases · December 2017
ObjectivesWe determined the seroprevalence of chikungunya virus (CHIKV) infection in the adult resident population in Singapore following local outbreaks of chikungunya fever (CHIKF) in 2008-2009.MethodsOur cross-sectional study involved ...
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Journal ArticleThe Journal of infectious diseases · July 2017
BackgroundZika virus (ZIKV) infections have been linked to different levels of clinical outcomes, ranging from mild rash and fever to severe neurological complications and congenital malformations.MethodsWe investigated the clinical and i ...
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Journal ArticleJournal of medicinal chemistry · April 2017
Chikungunya virus (CHIKV) is a re-emerging vector-borne alphavirus, and there is no approved effective antiviral treatment currently available for CHIKV. We previously reported the discovery of thieno[3,2-b]pyrrole 1b that displayed good antiviral activity ...
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Journal ArticleViruses · March 2024
Avian influenza viruses (AIVs) have posed a significant pandemic threat since their discovery. This review mainly focuses on the epidemiology, virology, pathogenesis, and treatments of avian influenza viruses. We delve into the global spread, past pandemic ...
Full textCite
Journal ArticleClinical & translational immunology · January 2020
ObjectivesLittle is known about the prevalence of febrile illness in the Arabian region as clinical, laboratory and immunological profiling remains largely uncharacterised.MethodsA total of 2018 febrile patients from Jazan, Saudi Arabia, ...
Full textCite
Journal ArticleThe Journal of infectious diseases · June 2019
BackgroundZika virus (ZIKV) infections have reemerged as a global health issue due to serious clinical complications. Development of specific serological assays to detect and differentiate ZIKV from other cocirculating flaviviruses for accurate di ...
Full textCite
Journal ArticleClinical & translational immunology · January 2019
ObjectivesRecent Zika virus (ZIKV) outbreaks challenged existing laboratory diagnostic standards, especially for serology-based methods. Because of the genetic and structural similarity of ZIKV with other flaviviruses, this results in cross-reacti ...
Full textCite
Journal ArticleScientific reports · November 2018
Animal models that recapitulate the human pathophysiology have been developed as useful research tools. Although laboratory mice are widely used, they are phylogenetically "distant" to humans. New world monkeys, such as the common marmoset (Callithrix jacc ...
Full textCite
Journal ArticleJournal of the peripheral nervous system : JPNS · September 2018
Although individuals with Zika virus (ZIKV) antibodies were reported in Malaya in mid-1950s, entomological and human surveillance in Singapore did not identify autochthonous transmission until the outbreak of August-November, 2016. A total of 455 cases fro ...
Full textCite
Journal ArticleThe Journal of infectious diseases · July 2018
BackgroundSince its unexpected reemergence, Zika virus (ZIKV) has caused numerous outbreaks globally. This study characterized the host immune responses during ZIKV infection.MethodsPatient samples were collected longitudinally during the ...
Full textCite
Journal ArticleScientific reports · March 2018
Infection with Zika virus (ZIKV), a mosquito-borne flavivirus has been casually linked with increased congenital microcephaly in Brazil from 2015 through 2016. Sensitive and specific diagnosis of patients with Zika fever (ZIKF) remains critical for patient ...
Full textCite
Journal ArticleScientific reports · January 2018
The arthropod-transmitted chikungunya virus (CHIKV) causes a flu-like disease that is characterized by incapacitating arthralgia. The re-emergence of CHIKV and the continual risk of new epidemics have reignited research in CHIKV pathogenesis. Virus-specifi ...
Full textCite
Journal ArticlePLoS neglected tropical diseases · December 2017
ObjectivesWe determined the seroprevalence of chikungunya virus (CHIKV) infection in the adult resident population in Singapore following local outbreaks of chikungunya fever (CHIKF) in 2008-2009.MethodsOur cross-sectional study involved ...
Full textCite
Journal ArticleThe Journal of infectious diseases · July 2017
BackgroundZika virus (ZIKV) infections have been linked to different levels of clinical outcomes, ranging from mild rash and fever to severe neurological complications and congenital malformations.MethodsWe investigated the clinical and i ...
Full textCite
Journal ArticleJournal of medicinal chemistry · April 2017
Chikungunya virus (CHIKV) is a re-emerging vector-borne alphavirus, and there is no approved effective antiviral treatment currently available for CHIKV. We previously reported the discovery of thieno[3,2-b]pyrrole 1b that displayed good antiviral activity ...
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Journal ArticleJCI insight · April 2017
Zika virus (ZIKV) infections have been linked with neurological complications and congenital Zika syndrome. Given the high level of homology between ZIKV and the related flavivirus dengue virus (DENV), we investigated the level of cross-reactivity with ZIK ...
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Journal ArticleThe Journal of infectious diseases · January 2017
Background Dengue virus infection typically causes mild dengue fever, but, in severe cases, life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) occur. The pathophysiological hallmark of DHF and DSS is plasma leakage tha ...
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Journal ArticleScientific reports · May 2016
Chikungunya fever (CHIKF) is a global infectious disease which can affect a wide range of age groups. The pathological and immunological response upon Chikungunya virus (CHIKV) infection have been reported over the last few years. However, the clinical pro ...
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Journal ArticleJournal of medicinal chemistry · December 2015
Chikungunya virus (CHIKV) is a re-emerging vector-borne alphavirus and is transmitted to humans by Aedes mosquitoes. Despite the re-emergence of CHIKV as an epidemic threat, there is no approved effective antiviral treatment currently available for CHIKV. ...
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Journal ArticleJournal of virological methods · September 2015
Chikungunya fever (CHIKF) has re-emerged as an arboviral disease that mimics clinical symptoms of other diseases such as dengue, malaria, as well as other alphavirus-related illnesses leading to problems with definitive diagnosis of the infection. Herein w ...
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Journal ArticleJournal of virology · August 2015
UnlabelledChikungunya virus (CHIKV) is a mosquito-borne arthralgic alphavirus that has garnered international attention as an important emerging pathogen since 2005. More recently, it invaded the Caribbean islands and the Western Hemisphere. Intri ...
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Journal ArticleJournal of virology · August 2015
Chikungunya virus (CHIKV) infection is a re-emerging pandemic human arboviral disease. CD4+ T cells were previously shown to contribute to joint inflammation in the course of CHIKV infection in mice. The JES6-1 anti-IL-2 antibody selectively exp ...
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Journal ArticleThe Journal of infectious diseases · June 2015
BackgroundIndividuals infected with chikungunya virus (CHIKV) normally exhibit a variety of clinical manifestations during the acute phase of infection. However, studies in different patient cohorts have revealed that disease manifestations vary i ...
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Journal ArticleEMBO molecular medicine · January 2015
RNA-sensing toll-like receptors (TLRs) mediate innate immunity and regulate anti-viral response. We show here that TLR3 regulates host immunity and the loss of TLR3 aggravates pathology in Chikungunya virus (CHIKV) infection. Susceptibility to CHIKV infect ...
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Journal ArticlePLoS neglected tropical diseases · January 2015
Chikungunya virus (CHIKV) and clinically-related arboviruses cause large epidemics with serious economic and social impact. As clinical symptoms of CHIKV infections are similar to several flavivirus infections, good detection methods to identify CHIKV infe ...
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Journal ArticlePloS one · January 2014
Chikungunya virus (CHIKV) is an Alphavirus that causes chronic and incapacitating arthralgia in humans. Although patient cohort studies have shown the production of CHIKV specific antibodies, the fine specificity of the antibody response against CHIKV is n ...
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Journal ArticleJournal of immunology (Baltimore, Md. : 1950) · June 2013
In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV infection in both humans and mice, their exact role in the control of CHIKV inf ...
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Journal ArticleVirology journal · May 2013
BackgroundA comparative analysis of the genomic and replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central and South African (ECSA) lineage was performed.FindingsAnalysis of the data reveale ...
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Journal ArticleJournal of virology · December 2012
Chikungunya virus (CHIKV) is an alphavirus which causes chronic and incapacitating arthralgia in humans. Although previous studies have shown that antibodies against the virus are produced during and after infection, the fine specificity of the antibody re ...
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Journal ArticleThe Journal of infectious diseases · April 2012
BackgroundChikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. Although infected individuals clear the virus from the blood, some develop debilitating and pro ...
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Journal ArticleEMBO molecular medicine · April 2012
Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. The immune mechanisms, which control viral multiplication and dissemination, are not yet known. Here, we studied t ...
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Journal ArticleHong Kong medical journal = Xianggang yi xue za zhi · February 2012
1. A SARS vaccine was produced based on recombinant native full-length Spike-protein trimers (triSpike) and efficient establishment of a vaccination procedure in rodents. 2. Antibody-mediated enhancement of SARS-CoV infection with anti-SARS-CoV Spike immun ...
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Journal ArticlePLoS pathogens · December 2011
Chikungunya virus (CHIKV) is an alphavirus responsible for numerous epidemics throughout Africa and Asia, causing infectious arthritis and reportedly linked with fatal infections in newborns and elderly. Previous studies in animal models indicate that humo ...
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Journal ArticleFuture Virology · August 1, 2011
Chikungunya virus (CHIKV), a dormant 'old world alphavirus, has warranted worldwide research attention due to the explosive nature of its outbreak events during 2004-2008. Despite being around for more than 50 years, CHIKV still remains elusive compared wi ...
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Journal ArticleBMC genomics · December 2010
BackgroundThe identification of B-cell epitopes on antigens has been a subject of intense research as the knowledge of these markers has great implications for the development of peptide-based diagnostics, therapeutics and vaccines. As experimenta ...
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Journal ArticleMicrobes and infection · December 2009
The re-emergence of Chikungunya fever, an old tropical infectious disease with new characteristics represents a major public health problem with severe social and economic burdens globally. Though Chikungunya has previously been known as a relatively benig ...
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Journal ArticleMicrobes and infection · December 2009
Chikungunya fever is an acute illness caused by the arbovirus Chikungunya virus. The virus is transmitted primarily in a sylvatic cycle involving the Aedes mosquitoes. Since 2005, a Chikungunya fever outbreak of unprecedented magnitude occurred on several ...
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Journal ArticlePloS one · November 2009
BackgroundEntry of enveloped viruses into host cells requires the activation of viral envelope glycoproteins through cleavage by either intracellular or extracellular proteases. In order to gain insight into the molecular basis of protease cleavag ...
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Journal ArticleJournal of virology · February 2008
Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the inte ...
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Journal ArticleVaccine · January 2007
Vaccine-induced antibodies can prevent or, in the case of feline infectious peritonitis virus, aggravate infections by coronaviruses. We investigated whether a recombinant native full-length S-protein trimer (triSpike) of severe acute respiratory syndrome ...
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Journal ArticleThe Journal of general virology · May 2005
Post-translational modifications and correct subcellular localization of viral structural proteins are prerequisites for assembly and budding of enveloped viruses. Coronaviruses, like the severe acute respiratory syndrome-associated virus (SARS-CoV), bud f ...
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Journal ArticleJournal of receptor and signal transduction research · February 2003
Mouse prostacyclin (mIP) receptors transiently expressed in Chinese hamster ovary (CHO) cells activated both adenylyl cyclase and phospholipase C, with a 33-fold preference for signaling through Gs. The prostacyclin (IP) receptor agonists cicaprost, ilopro ...
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Journal ArticleCellular signalling · November 2001
Octimibate and related nonprostanoid prostacyclin mimetics are partial agonists displaying highly tissue-specific responses. Octimibate demonstrated considerably greater efficacy for stimulation of adenylyl cyclase activity in Chinese hamster ovary cells t ...
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