Scholars@Duke
Yuan Wu

Yuan Wu

Associate Professor in Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
yuan.wu@duke.edu
Duke Box 2721, Durham, NC 27710
2424 Erwin Road, 11101 Hock Plaza Suite 1102, Durham, NC 27710

Selected Publications

A Pathological Diagnosis Method for Fever of Unknown Origin Based on Multipath Hierarchical Classification: Model Design and Validation.

Journal Article JMIR Form Res · December 9, 2024 BACKGROUND: Fever of unknown origin (FUO) is a significant challenge for the medical community due to its association with a wide range of diseases, the complexity of diagnosis, and the likelihood of misdiagnosis. Machine learning can extract valuable info ... Full text Link to item Cite

Exploring optimal settings for safe and effective thulium fibre laser lithotripsy in a kidney model.

Journal Article BJU Int · February 2024 OBJECTIVES: To explore the optimal laser settings and treatment strategies for thulium fibre laser (TFL) lithotripsy, namely, those with the highest treatment efficiency, lowest thermal injury risk, and shortest procedure time. MATERIALS AND METHODS: An in ... Full text Open Access Link to item Cite

Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness.

Journal Article Sci Rep · December 4, 2023 The lethality of epithelial ovarian cancer (OC) is largely due to a high rate of recurrence and development of chemoresistance, which requires synergy between cancer cells and the tumor microenvironment (TME) and is thought to involve cancer stem cells. Ou ... Full text Open Access Link to item Cite

Relationship Between Pretreatment Body Composition and Clinical Outcomes in Patients With Metastatic Renal Cell Carcinoma Receiving First-Line Ipilimumab Plus Nivolumab.

Journal Article Clin Genitourin Cancer · December 2023 INTRODUCTION: Biomarkers are needed to identify patients with metastatic renal cell carcinoma (mRCC) most likely to benefit from immune checkpoint inhibitors. We examined associations between radiographically assessed body composition (BC) variables and bo ... Full text Link to item Cite

Salvage Cryoablation for Recurrent Prostate Cancer Following Primary External Beam Radiotherapy or Primary Cryotherapy: A Propensity Score Matched Analysis of Mid-term Oncologic and Functional Outcomes.

Journal Article Clin Genitourin Cancer · October 2023 INTRODUCTION: Local prostate cancer recurrence following radiotherapy (XRT) or cryoablation (CRYO) may be addressed with salvage cryotherapy (SCT), although little is known about how the primary treatment modality affects SCT results. Oncologic and functio ... Full text Link to item Cite

Intermediate-term oncological and functional outcomes of salvage cryotherapy for the management of prostate cancer recurrence after primary brachytherapy versus primary cryotherapy: A propensity score-matched analysis.

Journal Article Prostate · October 2023 BACKGROUND: Salvage cryotherapy (SCT) is widely used to treat prostate cancer (PCa) recurrence after radiotherapy (RT). We studied the intermediate oncological and functional outcomes of patients who underwent SCT following cryotherapy (CRYO-SCT) recurrenc ... Full text Link to item Cite

Transcriptomic Signatures Associated With Outcomes in Recurrent Prostate Cancer Treated With Salvage Radiation, Androgen-Deprivation Therapy, and Enzalutamide: Correlative Analysis of the STREAM Trial.

Journal Article JCO Precis Oncol · August 2023 PURPOSE: Men with rising prostate-specific antigen (PSA) after radical prostatectomy (RP) may progress despite radiation and androgen-deprivation therapy (ADT). Tissue-based transcriptomic signatures can identify who may benefit from a more aggressive syst ... Full text Link to item Cite

Is time to castration resistant prostate cancer a potential intermediate end-point for time to metastasis among men initiating androgen deprivation therapy for non-metastatic prostate cancer with rapid PSA doubling time (<9 months)?

Journal Article Prostate Cancer Prostatic Dis · March 2023 PURPOSE: Metastasis-free survival (MFS) is a surrogate for overall survival (OS) in men with non-metastatic castration-resistant prostate cancer (CRPC), but this endpoint may take years to develop in men with non-metastatic castrate-sensitive disease. The ... Full text Link to item Cite

Real-world effectiveness of antifungal prophylaxis with posaconazole as the primary agent in patients with haematological malignancies.

Journal Article Mycoses · November 2022 BACKGROUND AND OBJECTIVES: Patients undergoing induction/reinduction chemotherapy for haematologic malignancies (HM) are at risk for invasive fungal infections (IFIs). In 2015, Duke University Hospital (DUH) implemented a new standardised fungal prophylaxi ... Full text Link to item Cite

The Effects of Scanning Speed and Standoff Distance of the Fiber on Dusting Efficiency during Short Pulse Holmium: YAG Laser Lithotripsy.

Journal Article J Clin Med · August 28, 2022 To investigate the effects of fiber lateral scanning speed across the stone surface (vfiber) and fiber standoff distance (SD) on dusting efficiency during short pulse holmium (Ho): YAG laser lithotripsy (LL), pre-soaked BegoStone samples were treated in wa ... Full text Link to item Cite

The BivarIntCensored: An R Package for Nonparametric Inference of Bivariate Interval-Censored Data

Chapter · July 15, 2022 Bivariate event time data are constantly encountered in biomedical research. In many real-life applications, both event times are possibly subject to interval censoring that gives rise to bivariate interval-censored data. Nonparametric inference of bivaria ... Full text Cite

A spline-based nonparametric analysis for interval-censored bivariate survival data.

Journal Article Stat Sin · July 2022 In this manuscript we propose a spline-based sieve nonparametric maximum likelihood estimation method for joint distribution function with bivariate interval-censored data. We study the asymptotic behavior of the proposed estimator by proving the consisten ... Full text Link to item Cite

A phase 2 trial of avelumab in men with aggressive-variant or neuroendocrine prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · April 2022 BACKGROUND: Men with progressive neuroendocrine or aggressive-variant metastatic prostate cancer (NEPC/AVPC) have a poor prognosis and limited treatment options, and immunotherapy has not been tested in such patients. METHODS: We conducted an open label si ... Full text Link to item Cite

A randomized controlled trial comparing changes in fitness with or without supervised exercise in patients initiated on enzalutamide and androgen deprivation therapy for non-metastatic castration-sensitive prostate cancer (EXTEND).

Journal Article Prostate Cancer Prostatic Dis · March 2022 BACKGROUND: Androgen deprivation therapy (ADT) and androgen receptor signaling inhibitors (ARSI) are associated with deleterious physical effects, which exercise may mitigate; however, exercise has never been studied in patients initiating treatment with A ... Full text Link to item Cite

Phase II Trial of Enzalutamide and Androgen Deprivation Therapy with Salvage Radiation in Men with High-risk Prostate-specific Antigen Recurrent Prostate Cancer: The STREAM Trial.

Journal Article Eur Urol Oncol · December 2021 BACKGROUND: Salvage external beam radiotherapy (RT) with androgen deprivation therapy (ADT) improves survival over RT in men with prostate cancer (PC) and rising prostate-specific antigen (PSA) levels after radical prostatectomy (RP). OBJECTIVE: To investi ... Full text Link to item Cite

Predictive Value of Combining Biomarkers for Clinical Outcomes in Advanced Non-Small Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors.

Journal Article Clin Lung Cancer · November 2021 INTRODUCTION: A high tumor mutational burden (TMB) (≥10 mut/Mb) has been associated with improved clinical benefit in non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICI) and is a tumor agnostic indication for pembrolizumab ac ... Full text Link to item Cite

LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multiple cancer types.

Journal Article J Immunother Cancer · March 2021 BACKGROUND: Low-density lipoprotein receptor-related protein 1b (encoded by LRP1B) is a putative tumor suppressor, and preliminary evidence suggests LRP1B-mutated cancers may have improved outcomes with immune checkpoint inhibitors (ICI). METHODS: We condu ... Full text Open Access Link to item Cite

Interim analysis of STARTAR: A phase II salvage trial of androgen receptor (AR) inhibition with androgen deprivation therapy (ADT) and apalutamide with radiation therapy (RT) followed by docetaxel in men with PSA recurrent prostate cancer (PC) after radical prostatectomy (RP).

Conference Journal of Clinical Oncology · February 20, 2021 90 Background: ADT with salvage RT improves survival for men with PSA recurrence after RP. Current standard duration of ADT for high risk PSA recurrence is up to 2 years with RT; therefore shortening but intensifying systemic the ... Full text Cite

ASSET: Alternative schedule sunitinib in metastatic renal cell carcinoma (RCC)—Cardiopulmonary exercise testing (CPET).

Conference Journal of Clinical Oncology · February 20, 2021 300 Background: Sunitinib (SUN) is a vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor (TKI) approved for treatment of advanced RCC and high risk RCC after nephrectomy. Evidence suggests that a 2 week (wk) on, 1 ... Full text Cite

Efficacy of the PD-L1 inhibitor avelumab in neuroendocrine or aggressive variant prostate cancer: Results from a phase II, single-arm study.

Conference Journal of Clinical Oncology · February 20, 2021 89 Background: Men with metastatic neuroendocrine/small cell and aggressive variant prostate cancer (NEPC/AVPC) have poor outcomes despite platinum and taxane chemotherapy. These tumors share common features with small cell lung ... Full text Cite

Estimating Uncertainty Intervals from Collaborating Networks

Journal Article Journal of Machine Learning Research · 2021 Link to item Cite

Estimating Uncertainty Intervals from Collaborating Networks.

Journal Article J Mach Learn Res · 2021 Effective decision making requires understanding the uncertainty inherent in a prediction. In regression, this uncertainty can be estimated by a variety of methods; however, many of these methods are laborious to tune, generate overconfident uncertainty in ... Link to item Cite

PD-L1 Assay Concordance in Metastatic Renal Cell Carcinoma and Metastatic Urothelial Carcinoma.

Journal Article Clin Genitourin Cancer · December 2020 BACKGROUND: Immune checkpoint inhibitors are now standard of care for many patients with metastatic renal cell carcinoma (mRCC) and metastatic urothelial carcinoma (mUC). Given real-world limitations in programmed death-ligand 1 (PD-L1) testing, concordanc ... Full text Link to item Cite

Score and deviance residuals based on the full likelihood approach in survival analysis.

Journal Article Pharm Stat · November 2020 Assuming the proportional hazards model and non-informative censoring, the full likelihood approach is used to obtain two new residuals. The first residual is based on the ideas used in obtaining score-type residuals similar to the partial likelihood appro ... Full text Link to item Cite

Predictive accuracy of markers or risk scores for interval censored survival data.

Journal Article Stat Med · August 15, 2020 Methods for the evaluation of the predictive accuracy of biomarkers with respect to survival outcomes subject to right censoring have been discussed extensively in the literature. In cancer and other diseases, survival outcomes are commonly subject to inte ... Full text Link to item Cite

A Randomized Controlled Trial of a 6-Month Low-Carbohydrate Intervention on Disease Progression in Men with Recurrent Prostate Cancer: Carbohydrate and Prostate Study 2 (CAPS2).

Journal Article Clin Cancer Res · June 15, 2020 PURPOSE: Both weight loss and low-carbohydrate diets (LCD) without weight loss prolong survival in prostate cancer models. Few human trials have tested weight loss or LCD on prostate cancer. EXPERIMENTAL DESIGN: We conducted a multi-site randomized 6-month ... Full text Link to item Cite

Knowledge-Based Tradeoff Hyperplanes for Head and Neck Treatment Planning.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2020 PURPOSE: To develop a tradeoff hyperplane model to facilitate tradeoff decision-making before inverse planning. METHODS AND MATERIALS: We propose a model-based approach to determine the tradeoff hyperplanes that allow physicians to navigate the clinically ... Full text Link to item Cite

Evaluating treatment protocols for rectal squamous cell carcinomas: the Duke experience and literature.

Journal Article J Gastrointest Oncol · April 2020 BACKGROUND: Colorectal cancer is the third most common cancer in the United States and associated with significant morbidity and mortality. Within colorectal cancer histologies, squamous cell carcinomas (SCC) are rare compared to adenocarcinomas, with only ... Full text Link to item Cite

Multi-Institutional Analysis of Synchronous Prostate and Rectosigmoid Cancers.

Journal Article Front Oncol · 2020 Purpose: To perform a multi-institutional analysis of patients with synchronous prostate and rectosigmoid cancers. Materials and Methods: A retrospective review of Duke University and Durham Veterans Affairs Medical Center records was performed for men wit ... Full text Link to item Cite

Prolonged PSA stabilization and overall survival following sipuleucel-T monotherapy in metastatic castration-resistant prostate cancer patients.

Journal Article Prostate Cancer Prostatic Dis · December 2019 BACKGROUND: Sipuleucel-T is an autologous cellular immunotherapy that is FDA approved for the treatment of asymptomatic or minimally symptomatic metastatic castrate-resistant prostate cancer (mCRPC). The IMPACT registry trial demonstrated a 4.1 month survi ... Full text Link to item Cite

Clinical utility of FoundationOne tissue molecular profiling in men with metastatic prostate cancer.

Journal Article Urol Oncol · November 2019 PURPOSE: Targeted inhibitors and immunotherapy have entered the treatment landscape of metastatic prostate cancer. Genomic testing may uncover which patients benefit most from these therapies. We report the clinical utility and benefits of FoundationOne te ... Full text Link to item Cite

Pembrolizumab in men with heavily treated metastatic castrate-resistant prostate cancer.

Journal Article Cancer Med · August 2019 BACKGROUND: Pembrolizumab is approved for patients with metastatic, microsatellite instability (MSI)-high or mismatch repair-deficient (dMMR) solid tumors. However, very few men with prostate cancer were included in these initial studies. METHODS: We perfo ... Full text Link to item Cite

Semiparametric sieve maximum likelihood estimation under cure model with partly interval censored and left truncated data for application to spontaneous abortion.

Journal Article Lifetime Data Anal · July 2019 This work was motivated by observational studies in pregnancy with spontaneous abortion (SAB) as outcome. Clearly some women experience the SAB event but the rest do not. In addition, the data are left truncated due to the way pregnant women are recruited ... Full text Link to item Cite

A phase II Salvage Trial of AR Inhibition with ADT and Apalutamide with Radiation therapy followed by docetaxel in men with PSA recurrent prostate cancer (PC) after radical prostatectomy (STARTAR).

Conference Journal of Clinical Oncology · May 20, 2019 TPS5097 Background: Androgen deprivation combined with salvage external beam radiation therapy (RT) have improved survival for patients (pts) with non-metastatic hormone naïve PC and PSA recurrence after radical prostatectomy (RP ... Full text Cite

Immune checkpoint inhibitor response in tumors with LRP1B variants.

Conference Journal of Clinical Oncology · May 20, 2019 e14291 Background: Low-density lipoprotein receptor-related protein 1B (LRP1B) is a putative tumor suppressor gene spanning > 500 kb on chromosome 2. A melanoma study previously reported enrichment of LRP1B mutations in respon ... Full text Cite

Prevalence of pathogenic germline variants in DNA repair by race, age, and ethnicity in men with prostate cancer.

Conference Journal of Clinical Oncology · May 20, 2019 5062 Background: Patients with advanced prostate cancer (PC) frequently harbor pathogenic or likely pathogenic (P/LP) germline variants (GVs) in mismatch repair (MMR) and homologous repair (HR) enzymes which have clinical and tre ... Full text Cite

Interval Censoring

Chapter · April 24, 2019 Some of the recommended methods can be generally adapted and applied to combination studies; however, at this point, ... O'Quigley J, Pepe M, Fisher L. Continual reassessment method: A practical design for phase I clinical trials in cancer. ... Cite

Multi-institutional analysis of synchronous prostate and rectosigmoid cancers.

Conference Journal of Clinical Oncology · March 1, 2019 33 Background: Synchronous prostate cancer (PC) and rectosigmoid (RS) cancer (RSC) is a challenging clinical situation. Methods: A retrospective review of Duke University and Durham VA charts was performed for men with adenocarci ... Full text Cite

Pembrolizumab in men with heavily treated metastatic castration-resistant prostate cancer (mCRPC).

Conference Journal of Clinical Oncology · March 1, 2019 172 Background: Pembrolizumab is approved for patients with metastatic, microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) solid tumors who have progressed on prior therapy and have no satisfactory treatm ... Full text Cite

PEAX: Men with metastatic castrate-resistant prostate cancer (mCRPC) treated with either sipuleucel-T (SIP-T), enzalutamide (ENZA) or abiraterone acetate (ABI) undergoing cardiopulmonary exercise testing (CPET).

Conference Journal of Clinical Oncology · March 1, 2019 281 Background: Both ENZA and ABI are associated with significant toxicity to the cardiovascular-musculoskeletal system and physical side effects. However whether they cause a decline in cardiorespiratory fitness (CRF), as conven ... Full text Cite

Phase II trial enzalutamide and androgen deprivation therapy (ADT) with salvage radiation in men with high-risk PSA recurrent prostate cancer (PC): The STREAM trial.

Conference Journal of Clinical Oncology · March 1, 2019 29 Background: Salvage external beam radiotherapy (RT) and hormonal therapy improves survival over RT alone in men with non-metastatic hormone naïve PC and PSA recurrence after radical prostatectomy (RP). We investigated the safe ... Full text Cite

Sample size calculation for studies with grouped survival data.

Journal Article Stat Med · November 30, 2018 Grouped survival data arise often in studies where the disease status is assessed at regular visits to clinic. The time to the event of interest can only be determined to be between two adjacent visits or is right censored at one visit. In data analysis, r ... Full text Open Access Link to item Cite

Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer When the Prostate Specific Antigen is in the Diagnostic Gray Zone: Defining the Optimum Cutoff Point Stratified by Race and Body Mass Index.

Journal Article J Urol · October 2018 PURPOSE: We assessed the predictive value of prostate specific antigen density to detect clinically significant prostate cancer, defined as prostate cancer grade group 2 or greater, in a series of men undergoing prostate biopsy with prostate specific antig ... Full text Link to item Cite

Postoperative Radiation Therapy for Prostate Cancer: Comparison of Conventional Versus Hypofractionated Radiation Regimens.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2018 PURPOSE: To compare acute/late toxicity and biochemical control in contemporaneous prostate cancer patient cohorts treated with hypofractionated postprostatectomy radiation therapy (hypoPORT) or conventional PORT (coPORT). METHODS AND MATERIALS: Consecutiv ... Full text Link to item Cite

Chemotherapy or Combined Modality Therapy for Early-stage Hodgkin Lymphoma.

Journal Article Anticancer Res · May 2018 BACKGROUND/AIM: Optimizing treatment of early-stage Hodgkin lymphoma (HL) requires balancing cure with potential acute and late toxicities from treatment. We reviewed our institutional experience with chemotherapy alone (ChT) versus combined modality thera ... Full text Link to item Cite

Platinum sensitivity in metastatic prostate cancer: does histology matter?

Journal Article Prostate Cancer Prostatic Dis · April 2018 BACKGROUND: Platinum-based chemotherapy is effective in men with neuroendocrine prostate cancer (NEPC), but it is unclear whether histology (adenocarcinoma vs. non-adenocarcinoma NEPC variants) is predictive of platinum sensitivity. Given that NEPC exists ... Full text Link to item Cite

Consolidation Radiation Therapy for Patients With Advanced Hodgkin Lymphoma in Complete Metabolic Response According to PET-CT or Gallium Imaging.

Journal Article Clin Lymphoma Myeloma Leuk · February 2018 INTRODUCTION: The purpose of this study was to evaluate the role of consolidation radiation therapy (RT) in advanced Hodgkin lymphoma (HL) in the setting of a complete metabolic response (CR) to chemotherapy (ChT). PATIENTS AND METHODS: Patients with stage ... Full text Link to item Cite

Prostate-specific antigen response in black and white patients treated with abiraterone acetate for metastatic castrate-resistant prostate cancer.

Journal Article Urol Oncol · June 2017 PURPOSE: Evidence suggests differences in androgen receptor AR signaling between black (B) and white (W) patients with prostate cancer, but pivotal trials of abiraterone acetate (AA) for patients with metastatic castration-resistant prostate cancer (mCRPC) ... Full text Link to item Cite

Association of neuroendocrine phenotype with platinum chemotherapy outcomes in men with metastatic prostate cancer.

Conference Journal of Clinical Oncology · May 20, 2017 e16532 Background: DNA repair defects are common in men with mCRPC, and platinum chemotherapy may have a role in selected patients. We aimed to determine whether neuroendocrine variant prostate cancer (NEPC) is associated with a ... Full text Cite

Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer.

Journal Article Eur Urol · November 2016 UNLABELLED: We completed targeted exome sequencing of the tumors of 50 patients with pTis-pT4b bladder cancer. Mutations were categorized by type, stratified against previously identified cancer loci in the Catalogue of Somatic Mutations in Cancer and The ... Full text Link to item Cite

Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS).

Journal Article Breast Cancer Res Treat · June 2016 Current evidence suggests that the majority of DCIS lesions do not progress to invasive carcinoma, and overtreatment of DCIS is a significant problem. We previously reported an 8-gene signature that differentiated microdissected low-grade (LG) DCIS lesions ... Full text Link to item Cite

Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era.

Journal Article Ann Surg Oncol · March 2016 BACKGROUND: The role of adjuvant radiation therapy (RT) in the treatment of resected, locally advanced colon cancer is unclear. One randomized controlled trial (Intergroup-0130) addressed this question but failed to meet its accrual goals. Since this trial ... Full text Link to item Cite

WebDISCO: a web service for distributed cox model learning without patient-level data sharing.

Journal Article J Am Med Inform Assoc · November 2015 OBJECTIVE: The Cox proportional hazards model is a widely used method for analyzing survival data. To achieve sufficient statistical power in a survival analysis, it usually requires a large amount of data. Data sharing across institutions could be a poten ... Full text Link to item Cite

Low-dose consolidation radiation therapy for early stage unfavorable Hodgkin lymphoma.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2015 PURPOSE: The German Hodgkin Study Group (GHSG) trial HD11 established 4 cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and 30 Gy of radiation therapy (RT) as a standard for early stage (I, II), unfavorable Hodgkin lymphoma (HL). Addi ... Full text Link to item Cite

Grid multi-category response logistic models.

Journal Article BMC Med Inform Decis Mak · February 18, 2015 BACKGROUND: Multi-category response models are very important complements to binary logistic models in medical decision-making. Decomposing model construction by aggregating computation developed at different sites is necessary when data cannot be moved ou ... Full text Link to item Cite

Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma.

Journal Article J Gastrointest Oncol · December 2014 BACKGROUND: Cervical esophageal carcinoma (CEC) is an uncommon malignancy. Limited data supports the use of definitive chemoradiotherapy (CRT) as primary treatment. Furthermore, the role of human papillomavirus (HPV) tumor infection in CEC remains unknown. ... Full text Link to item Cite

Definitive Chemoradiation Therapy for Cervical Esophageal Carcinoma: A Single-Institution Experience

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Low-Dose Consolidation Radiation Therapy for Early-Stage Unfavorable Hodgkin Lymphoma

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Development of a web service for analysis in a distributed network.

Journal Article EGEMS (Wash DC) · 2014 OBJECTIVE: We describe functional specifications and practicalities in the software development process for a web service that allows the construction of the multivariate logistic regression model, Grid Logistic Regression (GLORE), by aggregating partial e ... Full text Open Access Link to item Cite

Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma

Journal Article Journal of Gastrointestinal Oncology · January 1, 2014 Background: Cervical esophageal carcinoma (CEC) is an uncommon malignancy. Limited data supports the use of definitive chemoradiotherapy (CRT) as primary treatment. Furthermore, the role of human papillomavirus (HPV) tumor infection in CEC remains unknown. ... Full text Cite

WebGLORE: a web service for Grid LOgistic REgression.

Journal Article Bioinformatics · December 15, 2013 UNLABELLED: WebGLORE is a free web service that enables privacy-preserving construction of a global logistic regression model from distributed datasets that are sensitive. It only transfers aggregated local statistics (from participants) through Hypertext ... Full text Link to item Cite

B-Spline-based sieve estimation in survival analysis

Journal Article Annals of Biometrics and Biostatistics · July 5, 2013 Cite

EXpectation Propagation LOgistic REgRession (EXPLORER): distributed privacy-preserving online model learning.

Journal Article J Biomed Inform · June 2013 We developed an EXpectation Propagation LOgistic REgRession (EXPLORER) model for distributed privacy-preserving online learning. The proposed framework provides a high level guarantee for protecting sensitive information, since the information exchanged be ... Full text Link to item Cite

Cancer risk in children and adolescents with birth defects: a population-based cohort study.

Journal Article PLoS One · 2013 OBJECTIVE: Birth defects are an increasing health priority worldwide, and the subject of a major 2010 World Health Assembly Resolution. Excess cancer risk may be an added burden in this vulnerable group of children, but studies to date have provided incons ... Full text Link to item Cite

Youth violence across multiple dimensions: a study of violence, absenteeism, and suspensions among middle school children.

Journal Article J Pediatr · September 2012 OBJECTIVE: To determine how multidimensional measures of violence correlate with school absenteeism and suspensions among middle school youth. STUDY DESIGN: A cross-sectional survey was conducted in 2004 with 28 882 sixth graders from an urban school distr ... Full text Link to item Cite

Grid Binary LOgistic REgression (GLORE): building shared models without sharing data.

Journal Article J Am Med Inform Assoc · 2012 OBJECTIVE: The classification of complex or rare patterns in clinical and genomic data requires the availability of a large, labeled patient set. While methods that operate on large, centralized data sources have been extensively used, little attention has ... Full text Link to item Cite

Preserving Institutional Privacy in Distributed binary Logistic Regression.

Conference AMIA Annu Symp Proc · 2012 Privacy is becoming a major concern when sharing biomedical data across institutions. Although methods for protecting privacy of individual patients have been proposed, it is not clear how to protect the institutional privacy, which is many times a critica ... Link to item Cite

Selecting cases for whom additional tests can improve prognostication.

Conference AMIA Annu Symp Proc · 2012 Prognostic models are increasingly being used in clinical practice. The benefit of adding variables (e.g., gene expression measurements) to an original set of variables (e.g., phenotypes) when building prognostic models is usually measured on a whole set o ... Link to item Cite

Sieve Estimation with Bivariate Interval Censored Data

Journal Article Journal of Statistics: Advances in Theory and Applications · 2011 Cite

Changes in skeletal muscle cross sectional area (CSA) in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with enzalutamide (ENZ).

Journal Article Journal of Clinical Oncology Background: Phase III studies that led to ENZ approval in the treatment of mCRPC included side effects like fatigue, musculoskeletal pain, and falls, which could result from skeletal muscle loss. Such muscle loss (sarcopenia), in a variety of cancer popula ... Full text Link to item Cite