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Clinical utility of FoundationOne tissue molecular profiling in men with metastatic prostate cancer.

Publication ,  Journal Article
Zhu, J; Tucker, M; Marin, D; Gupta, RT; Healy, P; Humeniuk, M; Jarvis, C; Zhang, T; McNamara, M; George, DJ; Wu, Y; Lisi, S; Armstrong, AJ
Published in: Urol Oncol
November 2019

PURPOSE: Targeted inhibitors and immunotherapy have entered the treatment landscape of metastatic prostate cancer. Genomic testing may uncover which patients benefit most from these therapies. We report the clinical utility and benefits of FoundationOne testing in men with advanced prostate cancer. PATIENTS AND METHODS: We retrospectively identified all men with prostate cancer who received tissue FoundationOne testing at our institution between January 2010 and April 2017. Genomic alterations, treatment selection based on FoundationOne results, and clinical outcomes including response and duration of therapy following matched targeted therapy were analyzed. RESULTS: A total of 77 men with metastatic prostate cancer were referred for FoundationOne testing; 59 (77%) had sufficient tumor tissue for testing. Of these, 22% (17/77) of men had a targetable mutation and 9% (7/77) of men received matched off-label targeted therapy. Overall, 5% (4/77) of patients derived clinical benefit. One patient with a BRCA2 loss had a complete response on olaparib (>27 months) and 3 patients (ATM substitution, PALB2 frameshift, CDK12 frameshift) had stable disease with olaparib (10.3, 18.7, and 7.8 months, respectively). Three patients (BRCA2 frameshift, PDL1 + PDL2 amplification, PMS2 missense) had progressive disease despite targeted therapy. CONCLUSIONS: Tissue genomic testing can uncover patients who may benefit from targeted therapies such as poly(adenosine diphosphate-ribose) polymerase inhibitors or immunotherapy. In our limited single institution study, genomic testing led to clinical benefit in 5% of patients. Combined germline and circulating tumor DNA testing may be helpful to identify additional patients suitable for matched genomic therapies.

Duke Scholars

Published In

Urol Oncol

DOI

EISSN

1873-2496

Publication Date

November 2019

Volume

37

Issue

11

Start / End Page

813.e1 / 813.e9

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Treatment Outcome
  • Retrospective Studies
  • Prostatic Neoplasms
  • Precision Medicine
  • Mutation
  • Molecular Targeted Therapy
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhu, J., Tucker, M., Marin, D., Gupta, R. T., Healy, P., Humeniuk, M., … Armstrong, A. J. (2019). Clinical utility of FoundationOne tissue molecular profiling in men with metastatic prostate cancer. Urol Oncol, 37(11), 813.e1-813.e9. https://doi.org/10.1016/j.urolonc.2019.06.015
Zhu, Jason, Matthew Tucker, Daniele Marin, Rajan T. Gupta, Patrick Healy, Michael Humeniuk, Casey Jarvis, et al. “Clinical utility of FoundationOne tissue molecular profiling in men with metastatic prostate cancer.Urol Oncol 37, no. 11 (November 2019): 813.e1-813.e9. https://doi.org/10.1016/j.urolonc.2019.06.015.
Zhu J, Tucker M, Marin D, Gupta RT, Healy P, Humeniuk M, et al. Clinical utility of FoundationOne tissue molecular profiling in men with metastatic prostate cancer. Urol Oncol. 2019 Nov;37(11):813.e1-813.e9.
Zhu, Jason, et al. “Clinical utility of FoundationOne tissue molecular profiling in men with metastatic prostate cancer.Urol Oncol, vol. 37, no. 11, Nov. 2019, pp. 813.e1-813.e9. Pubmed, doi:10.1016/j.urolonc.2019.06.015.
Zhu J, Tucker M, Marin D, Gupta RT, Healy P, Humeniuk M, Jarvis C, Zhang T, McNamara M, George DJ, Wu Y, Lisi S, Armstrong AJ. Clinical utility of FoundationOne tissue molecular profiling in men with metastatic prostate cancer. Urol Oncol. 2019 Nov;37(11):813.e1-813.e9.
Journal cover image

Published In

Urol Oncol

DOI

EISSN

1873-2496

Publication Date

November 2019

Volume

37

Issue

11

Start / End Page

813.e1 / 813.e9

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Treatment Outcome
  • Retrospective Studies
  • Prostatic Neoplasms
  • Precision Medicine
  • Mutation
  • Molecular Targeted Therapy
  • Middle Aged
  • Male
  • Humans