Skip to main content
Journal cover image

Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.

Publication ,  Journal Article
Blum, JM; Añó, L; Li, Z; Van Mater, D; Bennett, BD; Sachdeva, M; Lagutina, I; Zhang, M; Mito, JK; Dodd, LG; Cardona, DM; Dodd, RD; Ma, Y ...
Published in: Cell Rep
November 27, 2013

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, whereas undifferentiated pleomorphic sarcoma (UPS) is one of the most common soft tissue sarcomas diagnosed in adults. To investigate the myogenic cell(s) of origin of these sarcomas, we used Pax7-CreER and MyoD-CreER mice to transform Pax7(+) and MyoD(+) myogenic progenitors by expressing oncogenic Kras(G12D) and deleting Trp53 in vivo. Pax7-CreER mice developed RMS and UPS, whereas MyoD-CreER mice developed UPS. Using gene set enrichment analysis, RMS and UPS each clustered specifically within their human counterparts. These results suggest that RMS and UPS have distinct and overlapping cells of origin within the muscle lineage. Taking them together, we have established mouse models of soft tissue sarcoma from muscle stem and progenitor cells.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

November 27, 2013

Volume

5

Issue

4

Start / End Page

933 / 940

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Rhabdomyosarcoma
  • Proto-Oncogene Proteins p21(ras)
  • PAX7 Transcription Factor
  • Neoplastic Stem Cells
  • Myoblasts, Skeletal
  • MyoD Protein
  • Muscle Development
  • Mice, Transgenic
  • Mice, Inbred C57BL
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Blum, J. M., Añó, L., Li, Z., Van Mater, D., Bennett, B. D., Sachdeva, M., … Kirsch, D. G. (2013). Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. Cell Rep, 5(4), 933–940. https://doi.org/10.1016/j.celrep.2013.10.020
Blum, Jordan M., Leonor Añó, Zhizhong Li, David Van Mater, Brian D. Bennett, Mohit Sachdeva, Irina Lagutina, et al. “Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.Cell Rep 5, no. 4 (November 27, 2013): 933–40. https://doi.org/10.1016/j.celrep.2013.10.020.
Blum JM, Añó L, Li Z, Van Mater D, Bennett BD, Sachdeva M, et al. Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. Cell Rep. 2013 Nov 27;5(4):933–40.
Blum, Jordan M., et al. “Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.Cell Rep, vol. 5, no. 4, Nov. 2013, pp. 933–40. Pubmed, doi:10.1016/j.celrep.2013.10.020.
Blum JM, Añó L, Li Z, Van Mater D, Bennett BD, Sachdeva M, Lagutina I, Zhang M, Mito JK, Dodd LG, Cardona DM, Dodd RD, Williams N, Ma Y, Lepper C, Linardic CM, Mukherjee S, Grosveld GC, Fan C-M, Kirsch DG. Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. Cell Rep. 2013 Nov 27;5(4):933–940.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

November 27, 2013

Volume

5

Issue

4

Start / End Page

933 / 940

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Rhabdomyosarcoma
  • Proto-Oncogene Proteins p21(ras)
  • PAX7 Transcription Factor
  • Neoplastic Stem Cells
  • Myoblasts, Skeletal
  • MyoD Protein
  • Muscle Development
  • Mice, Transgenic
  • Mice, Inbred C57BL