Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.
Publication
, Journal Article
Ren, XR; Wang, J; Osada, T; Mook, RA; Morse, MA; Barak, LS; Lyerly, HK; Chen, W
Published in: Breast Cancer Res
December 2015
Human epidermal growth factor receptor HER3 has been implicated in promoting the aggressiveness and metastatic potential of breast cancer. Upregulation of HER3 has been found to be a major mechanism underlying drug resistance to EGFR and HER2 tyrosine kinase inhibitors and to endocrine therapy in the treatment of breast cancer. Thus, agents that reduce HER3 expression at the plasma membrane may synergize with current therapies and offer a novel therapeutic strategy to improve treatment.
Duke Scholars
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Published In
Breast Cancer Res
DOI
EISSN
1465-542X
Publication Date
December 2015
Volume
17
Issue
1
Start / End Page
528
Location
England
Related Subject Headings
- Oncology & Carcinogenesis
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Ren, X. R., Wang, J., Osada, T., Mook, R. A., Morse, M. A., Barak, L. S., … Chen, W. (2015). Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. Breast Cancer Res, 17(1), 528. https://doi.org/10.1186/s13058-015-0528-9
Ren, X. R., J. Wang, T. Osada, R. A. Mook, M. A. Morse, L. S. Barak, H. K. Lyerly, and W. Chen. “Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.” Breast Cancer Res 17, no. 1 (December 2015): 528. https://doi.org/10.1186/s13058-015-0528-9.
Ren XR, Wang J, Osada T, Mook RA, Morse MA, Barak LS, et al. Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. Breast Cancer Res. 2015 Dec;17(1):528.
Ren, X. R., et al. “Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.” Breast Cancer Res, vol. 17, no. 1, Dec. 2015, p. 528. Pubmed, doi:10.1186/s13058-015-0528-9.
Ren XR, Wang J, Osada T, Mook RA, Morse MA, Barak LS, Lyerly HK, Chen W. Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. Breast Cancer Res. 2015 Dec;17(1):528.
Published In
Breast Cancer Res
DOI
EISSN
1465-542X
Publication Date
December 2015
Volume
17
Issue
1
Start / End Page
528
Location
England
Related Subject Headings
- Oncology & Carcinogenesis
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis