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Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence.

Publication ,  Journal Article
McClernon, FJ; Conklin, CA; Kozink, RV; Adcock, RA; Sweitzer, MM; Addicott, MA; Chou, Y-H; Chen, N-K; Hallyburton, MB; DeVito, AM
Published in: Neuropsychopharmacology
February 2016

Environments associated with prior drug use provoke craving and drug taking, and set the stage for lapse/relapse. Although the neurobehavioral bases of environment-induced drug taking have been investigated with animal models, the influence of drug-environments on brain function and behavior in clinical populations of substance users is largely unexplored. Adult smokers (n=40) photographed locations personally associated with smoking (personal smoking environments; PSEs) or personal nonsmoking environment (PNEs). Following 24-h abstinence, participants underwent fMRI scanning while viewing PSEs, PNEs, standard smoking and nonsmoking environments, as well as proximal smoking (eg, lit cigarette) and nonsmoking (eg, pencil) cues. Finally, in two separate sessions following 6-h abstinence they viewed either PSEs or PNEs while cue-induced self-reported craving and smoking behavior were assessed. Viewing PSEs increased blood oxygen level-dependent signal in right posterior hippocampus (pHPC; F(2,685)=3.74, p<0.024) and bilateral insula (left: F(2,685)=6.87, p=0.0011; right: F(2,685)=5.34, p=0.005). In the laboratory, viewing PSEs, compared with PNEs, was associated with higher craving levels (F(2,180)=18.32, p<0.0001) and greater ad lib smoking (F(1,36)=5.01, p=0.032). The effect of PSEs (minus PNEs) on brain activation in right insula was positively correlated with the effect of PSEs (minus PNEs) on number of puffs taken from a cigarette (r=0.6, p=0.001). Our data, for the first time in humans, elucidates the neural mechanisms that mediate the effects of real-world drug-associated environments on drug taking behavior under conditions of drug abstinence. These findings establish targets for the development and evaluation of treatments seeking to reduce environment provoked relapse.

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Published In

Neuropsychopharmacology

DOI

EISSN

1740-634X

Publication Date

February 2016

Volume

41

Issue

3

Start / End Page

877 / 885

Location

England

Related Subject Headings

  • Young Adult
  • Visual Perception
  • Tobacco Use Disorder
  • Substance Withdrawal Syndrome
  • Smoking
  • Psychiatry
  • Photic Stimulation
  • Neuropsychological Tests
  • Neural Pathways
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
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McClernon, F. J., Conklin, C. A., Kozink, R. V., Adcock, R. A., Sweitzer, M. M., Addicott, M. A., … DeVito, A. M. (2016). Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence. Neuropsychopharmacology, 41(3), 877–885. https://doi.org/10.1038/npp.2015.214
McClernon, F Joseph, Cynthia A. Conklin, Rachel V. Kozink, R Alison Adcock, Maggie M. Sweitzer, Merideth A. Addicott, Ying-hui Chou, Nan-kuei Chen, Matthew B. Hallyburton, and Anthony M. DeVito. “Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence.Neuropsychopharmacology 41, no. 3 (February 2016): 877–85. https://doi.org/10.1038/npp.2015.214.
McClernon FJ, Conklin CA, Kozink RV, Adcock RA, Sweitzer MM, Addicott MA, et al. Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence. Neuropsychopharmacology. 2016 Feb;41(3):877–85.
McClernon, F. Joseph, et al. “Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence.Neuropsychopharmacology, vol. 41, no. 3, Feb. 2016, pp. 877–85. Pubmed, doi:10.1038/npp.2015.214.
McClernon FJ, Conklin CA, Kozink RV, Adcock RA, Sweitzer MM, Addicott MA, Chou Y-H, Chen N-K, Hallyburton MB, DeVito AM. Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence. Neuropsychopharmacology. 2016 Feb;41(3):877–885.

Published In

Neuropsychopharmacology

DOI

EISSN

1740-634X

Publication Date

February 2016

Volume

41

Issue

3

Start / End Page

877 / 885

Location

England

Related Subject Headings

  • Young Adult
  • Visual Perception
  • Tobacco Use Disorder
  • Substance Withdrawal Syndrome
  • Smoking
  • Psychiatry
  • Photic Stimulation
  • Neuropsychological Tests
  • Neural Pathways
  • Middle Aged