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Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers.

Publication ,  Journal Article
Zhu, R; Baker, SS; Moylan, CA; Abdelmalek, MF; Guy, CD; Zamboni, F; Wu, D; Lin, W; Liu, W; Baker, RD; Govindarajan, S; Cao, Z; Farci, P ...
Published in: J Pathol
March 2016

Obese animals and non-alcoholic fatty liver disease (NAFLD) patients exhibit elevated blood alcohol, suggesting potential contributions of alcohol metabolism to the development of NAFLD. Liver gene expression in patients with biopsy-proven mild (N = 40) and severe (N = 32) NAFLD were compared to that in healthy liver donors (N = 7) and alcoholic hepatitis (AH; N = 15) using microarrays. Principal components analyses (PCA) revealed similar gene expression patterns between mild and severe NAFLD which clustered with those of AH but were distinct from those of healthy livers. Differential gene expression between NAFLD and healthy livers was consistent with established NAFLD-associated genes and NAFLD pathophysiology. Alcohol-metabolizing enzymes including ADH, ALDH, CYP2E1, and CAT were up-regulated in NAFLD livers. The expression level of alcohol-metabolizing genes in severe NAFLD was similar to that in AH. The NAFLD gene expression profiles provide new directions for future investigations to identify disease markers and targets for prevention and treatment, as well as to foster our understanding of NAFLD pathogenesis and pathophysiology. Particularly, increased expression of alcohol-metabolizing genes in NAFLD livers supports a role for endogenous alcohol metabolism in NAFLD pathology and provides further support for gut microbiome therapy in NAFLD management. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley © Sons, Ltd.

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Published In

J Pathol

DOI

EISSN

1096-9896

Publication Date

March 2016

Volume

238

Issue

4

Start / End Page

531 / 542

Location

England

Related Subject Headings

  • Transcriptome
  • Pathology
  • Obesity
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Humans
  • Gene Expression Profiling
  • Female
  • Biopsy
 

Citation

APA
Chicago
ICMJE
MLA
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Zhu, R., Baker, S. S., Moylan, C. A., Abdelmalek, M. F., Guy, C. D., Zamboni, F., … Zhu, L. (2016). Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers. J Pathol, 238(4), 531–542. https://doi.org/10.1002/path.4650
Zhu, Ruixin, Susan S. Baker, Cynthia A. Moylan, Manal F. Abdelmalek, Cynthia D. Guy, Fausto Zamboni, Dingfeng Wu, et al. “Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers.J Pathol 238, no. 4 (March 2016): 531–42. https://doi.org/10.1002/path.4650.
Zhu R, Baker SS, Moylan CA, Abdelmalek MF, Guy CD, Zamboni F, et al. Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers. J Pathol. 2016 Mar;238(4):531–42.
Zhu, Ruixin, et al. “Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers.J Pathol, vol. 238, no. 4, Mar. 2016, pp. 531–42. Pubmed, doi:10.1002/path.4650.
Zhu R, Baker SS, Moylan CA, Abdelmalek MF, Guy CD, Zamboni F, Wu D, Lin W, Liu W, Baker RD, Govindarajan S, Cao Z, Farci P, Diehl AM, Zhu L. Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers. J Pathol. 2016 Mar;238(4):531–542.
Journal cover image

Published In

J Pathol

DOI

EISSN

1096-9896

Publication Date

March 2016

Volume

238

Issue

4

Start / End Page

531 / 542

Location

England

Related Subject Headings

  • Transcriptome
  • Pathology
  • Obesity
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Humans
  • Gene Expression Profiling
  • Female
  • Biopsy