Skip to main content
Journal cover image

Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.

Publication ,  Journal Article
Singh, SK; Stogsdill, JA; Pulimood, NS; Dingsdale, H; Kim, YH; Pilaz, L-J; Kim, IH; Manhaes, AC; Rodrigues, WS; Pamukcu, A; Enustun, E ...
Published in: Cell
January 14, 2016

Proper establishment of synapses is critical for constructing functional circuits. Interactions between presynaptic neurexins and postsynaptic neuroligins coordinate the formation of synaptic adhesions. An isoform code determines the direct interactions of neurexins and neuroligins across the synapse. However, whether extracellular linker proteins can expand such a code is unknown. Using a combination of in vitro and in vivo approaches, we found that hevin, an astrocyte-secreted synaptogenic protein, assembles glutamatergic synapses by bridging neurexin-1alpha and neuroligin-1B, two isoforms that do not interact with each other. Bridging of neurexin-1alpha and neuroligin-1B via hevin is critical for the formation and plasticity of thalamocortical connections in the developing visual cortex. These results show that astrocytes promote the formation of synapses by modulating neurexin/neuroligin adhesions through hevin secretion. Our findings also provide an important mechanistic insight into how mutations in these genes may lead to circuit dysfunction in diseases such as autism.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

January 14, 2016

Volume

164

Issue

1-2

Start / End Page

183 / 196

Location

United States

Related Subject Headings

  • Thalamus
  • Synapses
  • Signal Transduction
  • Protein Isoforms
  • Neurons
  • Neural Cell Adhesion Molecules
  • Nervous System Diseases
  • Mice, Knockout
  • Mice
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Singh, S. K., Stogsdill, J. A., Pulimood, N. S., Dingsdale, H., Kim, Y. H., Pilaz, L.-J., … Eroglu, C. (2016). Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell, 164(1–2), 183–196. https://doi.org/10.1016/j.cell.2015.11.034
Singh, Sandeep K., Jeff A. Stogsdill, Nisha S. Pulimood, Hayley Dingsdale, Yong Ho Kim, Louis-Jan Pilaz, Il Hwan Kim, et al. “Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.Cell 164, no. 1–2 (January 14, 2016): 183–96. https://doi.org/10.1016/j.cell.2015.11.034.
Singh SK, Stogsdill JA, Pulimood NS, Dingsdale H, Kim YH, Pilaz L-J, et al. Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell. 2016 Jan 14;164(1–2):183–96.
Singh, Sandeep K., et al. “Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.Cell, vol. 164, no. 1–2, Jan. 2016, pp. 183–96. Pubmed, doi:10.1016/j.cell.2015.11.034.
Singh SK, Stogsdill JA, Pulimood NS, Dingsdale H, Kim YH, Pilaz L-J, Kim IH, Manhaes AC, Rodrigues WS, Pamukcu A, Enustun E, Ertuz Z, Scheiffele P, Soderling SH, Silver DL, Ji R-R, Medina AE, Eroglu C. Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell. 2016 Jan 14;164(1–2):183–196.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

January 14, 2016

Volume

164

Issue

1-2

Start / End Page

183 / 196

Location

United States

Related Subject Headings

  • Thalamus
  • Synapses
  • Signal Transduction
  • Protein Isoforms
  • Neurons
  • Neural Cell Adhesion Molecules
  • Nervous System Diseases
  • Mice, Knockout
  • Mice
  • Humans