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Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis.

Publication ,  Journal Article
Patel, YA; Henao, R; Moylan, CA; Guy, CD; Piercy, DL; Diehl, AM; Abdelmalek, MF
Published in: Am J Gastroenterol
November 2016

OBJECTIVES: The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is complex. Vitamin D (VitD) has been implicated in NAFLD pathogenesis because it has roles in immune modulation, cell differentiation and proliferation, and regulation of inflammation. We evaluated the association of VitD levels, hepatic gene expression for VitD metabolizing genes, and NAFLD histological severity. METHODS: Two adult cohorts, controls (n=39) and NAFLD (n=244), who underwent liver biopsy were compared. Two-sided t-tests or Wilcoxon's rank-sum tests for continuous predictors and chi-squared tests or Fisher's exact tests for categorical variables were used to analyze the association of VitD and NAFLD. Generalized linear models were used to analyze the association of VitD levels and VitD metabolizing genes with histological severity of NAFLD while adjusting for potential confounders and correcting for multiple comparisons. RESULTS: NAFLD patients were more likely than controls to have higher HbA1c (6.5±1.2 vs 5.9±1.0; P=0.009), a risk factor for VitD deficiency. However, no difference in VitD levels was observed between groups. VitD levels did not correlate with the severity of hepatic steatosis, lobular or portal inflammation, or ballooned hepatocytes after adjusting for confounding factors. Furthermore, no association was noted between VitD deficiency or differential expression of genes involved in VitD metabolism and severity of hepatic fibrosis or any other histologic feature of NAFLD. CONCLUSIONS: Neither VitD deficiency, nor hepatic expression of VitD-related genes, associate with the presence or histologic severity of NAFLD in patients. Hence, despite preclinical evidence implicating VitD in NAFLD pathogenesis, VitD deficiency does not appear to be associated with NAFLD severity in humans.

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Published In

Am J Gastroenterol

DOI

EISSN

1572-0241

Publication Date

November 2016

Volume

111

Issue

11

Start / End Page

1591 / 1598

Location

United States

Related Subject Headings

  • Vitamin D3 24-Hydroxylase
  • Vitamin D-Binding Protein
  • Vitamin D Deficiency
  • Vitamin D
  • Severity of Illness Index
  • Retrospective Studies
  • Retinoid X Receptors
  • Receptors, Calcitriol
  • RNA, Messenger
  • Peroxisome Proliferator-Activated Receptors
 

Citation

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MLA
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Patel, Y. A., Henao, R., Moylan, C. A., Guy, C. D., Piercy, D. L., Diehl, A. M., & Abdelmalek, M. F. (2016). Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis. Am J Gastroenterol, 111(11), 1591–1598. https://doi.org/10.1038/ajg.2016.406
Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis.Am J Gastroenterol 111, no. 11 (November 2016): 1591–98. https://doi.org/10.1038/ajg.2016.406.
Patel YA, Henao R, Moylan CA, Guy CD, Piercy DL, Diehl AM, et al. Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis. Am J Gastroenterol. 2016 Nov;111(11):1591–8.
Patel, Yuval A., et al. “Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis.Am J Gastroenterol, vol. 111, no. 11, Nov. 2016, pp. 1591–98. Pubmed, doi:10.1038/ajg.2016.406.
Patel YA, Henao R, Moylan CA, Guy CD, Piercy DL, Diehl AM, Abdelmalek MF. Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis. Am J Gastroenterol. 2016 Nov;111(11):1591–1598.

Published In

Am J Gastroenterol

DOI

EISSN

1572-0241

Publication Date

November 2016

Volume

111

Issue

11

Start / End Page

1591 / 1598

Location

United States

Related Subject Headings

  • Vitamin D3 24-Hydroxylase
  • Vitamin D-Binding Protein
  • Vitamin D Deficiency
  • Vitamin D
  • Severity of Illness Index
  • Retrospective Studies
  • Retinoid X Receptors
  • Receptors, Calcitriol
  • RNA, Messenger
  • Peroxisome Proliferator-Activated Receptors