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Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder.

Publication ,  Journal Article
Hauser, MA; Garrett, ME; Liu, Y; Dennis, MF; Kimbrel, NA; Beckham, JC; Ashley-Koch, AE ...
Published in: J Psychiatr Res
January 2017

The aim of the present study was to attempt to replicate the recently reported finding associating rs2400707 of the Adrenoceptor Beta 2, Surface (ADRB2) gene and childhood trauma on PTSD symptoms. Participants included a predominantly veteran cohort of non-Hispanic blacks (NHB; n = 949) and a pre-dominantly veteran cohort of non-Hispanic whites (NHW; n = 759). No main effects were observed for rs2400707 on PTSD diagnosis. Among the NHB participants, we observed an interaction between rs2400707 and history of childhood trauma, whereby with each additional A allele, the odds of having PTSD increased by 1.31, but only among those who had experienced childhood trauma (p = 0.038). The interaction with rs2400707 and childhood trauma was not observed among the NHW study participants (p = 0.892). Taken together, the findings from the present research provide further evidence that the adrenergic system may be an important modulator of PTSD risk; however, additional work is still needed to clarify the exact nature of the relationship between PTSD and rs2400707 of the ADRB2 gene.

Duke Scholars

Published In

J Psychiatr Res

DOI

EISSN

1879-1379

Publication Date

January 2017

Volume

84

Start / End Page

59 / 61

Location

England

Related Subject Headings

  • Veterans
  • United States Department of Veterans Affairs
  • United States
  • Surveys and Questionnaires
  • Stress Disorders, Post-Traumatic
  • Sex Factors
  • Receptors, Adrenergic, beta-2
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Hauser, M. A., Garrett, M. E., Liu, Y., Dennis, M. F., Kimbrel, N. A., Veterans Affairs Mid-Atlantic Mental Illness Research Education And Clinical Center Workgroup, ., … Ashley-Koch, A. E. (2017). Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder. J Psychiatr Res, 84, 59–61. https://doi.org/10.1016/j.jpsychires.2016.09.013
Hauser, Michael A., Melanie E. Garrett, Yutao Liu, Michelle F. Dennis, Nathan A. Kimbrel, Nathan A. Veterans Affairs Mid-Atlantic Mental Illness Research Education And Clinical Center Workgroup, Jean C. Beckham, and Allison E. Ashley-Koch. “Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder.J Psychiatr Res 84 (January 2017): 59–61. https://doi.org/10.1016/j.jpsychires.2016.09.013.
Hauser MA, Garrett ME, Liu Y, Dennis MF, Kimbrel NA, Veterans Affairs Mid-Atlantic Mental Illness Research Education And Clinical Center Workgroup, et al. Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder. J Psychiatr Res. 2017 Jan;84:59–61.
Hauser, Michael A., et al. “Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder.J Psychiatr Res, vol. 84, Jan. 2017, pp. 59–61. Pubmed, doi:10.1016/j.jpsychires.2016.09.013.
Hauser MA, Garrett ME, Liu Y, Dennis MF, Kimbrel NA, Veterans Affairs Mid-Atlantic Mental Illness Research Education And Clinical Center Workgroup, Beckham JC, Ashley-Koch AE. Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder. J Psychiatr Res. 2017 Jan;84:59–61.
Journal cover image

Published In

J Psychiatr Res

DOI

EISSN

1879-1379

Publication Date

January 2017

Volume

84

Start / End Page

59 / 61

Location

England

Related Subject Headings

  • Veterans
  • United States Department of Veterans Affairs
  • United States
  • Surveys and Questionnaires
  • Stress Disorders, Post-Traumatic
  • Sex Factors
  • Receptors, Adrenergic, beta-2
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Male