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Depressive symptoms and early mortality following lung transplantation: A pilot study.

Publication ,  Journal Article
Smith, PJ; Blumenthal, JA; Snyder, LD; Mathew, JP; Durheim, MT; Hoffman, BM; Rivelli, SK; Palmer, SM
Published in: Clin Transplant
February 2017

BACKGROUND: Impaired psychological function is common among lung transplant candidates and may affect clinical outcomes following transplantation. Although numerous studies have examined the relationship between pretransplant depression, quality of life (QoL), and post-transplant outcomes, few have examined the relationship between depression and QoL shortly following transplantation and subsequent clinical outcomes. We therefore examined the association between depression, QoL, and short-term mortality in a consecutive series of lung transplant recipients. METHODS: Depression (Patient Health Questionnaire-9; Hospital Anxiety and Depression Scale; Centers for Epidemiologic Studies Depression Scale) and QoL (UCSD Shortness of Breath Questionnaire; Pulmonary Quality of Life Scale) were assessed prior to transplantation (median 0.9 months [IQR=1.6]) and again approximately 2 weeks following transplantation (median=0.5 months [IQR=0.5]), in a series of 66 patients transplanted between March 2013 and April 2014. The association between psychiatric diagnoses from participants' comprehensive pretransplant assessment and mortality also was examined. Cox proportional hazards models were used to examine the association between depression, QoL, and mortality. RESULTS: During a median follow-up of 2.8 years (range 0.4-3.3), 21 patients died (32%). Greater depressive symptoms assessed shortly after transplant were associated with subsequent mortality (HR=2.17 [1.01, 4.67], P=.048), and this relationship persisted after controlling for primary graft dysfunction, duration of transplant hospitalization, and gender. In contrast, neither pretransplant depression, history of depression, nor QoL was associated with mortality. CONCLUSIONS: Greater post-transplant depressive symptoms are independently associated with mortality among lung transplant recipients.

Duke Scholars

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Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

February 2017

Volume

31

Issue

2

Location

Denmark

Related Subject Headings

  • Survival Rate
  • Surveys and Questionnaires
  • Surgery
  • Quality of Life
  • Prognosis
  • Pilot Projects
  • Middle Aged
  • Male
  • Lung Transplantation
  • Humans
 

Citation

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Smith, P. J., Blumenthal, J. A., Snyder, L. D., Mathew, J. P., Durheim, M. T., Hoffman, B. M., … Palmer, S. M. (2017). Depressive symptoms and early mortality following lung transplantation: A pilot study. Clin Transplant, 31(2). https://doi.org/10.1111/ctr.12874
Smith, Patrick J., James A. Blumenthal, Laurie D. Snyder, Joseph P. Mathew, Michael T. Durheim, Benson M. Hoffman, Sarah K. Rivelli, and Scott M. Palmer. “Depressive symptoms and early mortality following lung transplantation: A pilot study.Clin Transplant 31, no. 2 (February 2017). https://doi.org/10.1111/ctr.12874.
Smith PJ, Blumenthal JA, Snyder LD, Mathew JP, Durheim MT, Hoffman BM, et al. Depressive symptoms and early mortality following lung transplantation: A pilot study. Clin Transplant. 2017 Feb;31(2).
Smith, Patrick J., et al. “Depressive symptoms and early mortality following lung transplantation: A pilot study.Clin Transplant, vol. 31, no. 2, Feb. 2017. Pubmed, doi:10.1111/ctr.12874.
Smith PJ, Blumenthal JA, Snyder LD, Mathew JP, Durheim MT, Hoffman BM, Rivelli SK, Palmer SM. Depressive symptoms and early mortality following lung transplantation: A pilot study. Clin Transplant. 2017 Feb;31(2).

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

February 2017

Volume

31

Issue

2

Location

Denmark

Related Subject Headings

  • Survival Rate
  • Surveys and Questionnaires
  • Surgery
  • Quality of Life
  • Prognosis
  • Pilot Projects
  • Middle Aged
  • Male
  • Lung Transplantation
  • Humans