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Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest Period.

Publication ,  Journal Article
Spearman, P; Tomaras, GD; Montefiori, DC; Huang, Y; Elizaga, ML; Ferrari, G; Alam, SM; Isaacs, A; Ahmed, H; Hural, J; McElrath, MJ; Butler, C ...
Published in: J Infect Dis
May 5, 2019

BACKGROUND: The durability and breadth of human immunodeficiency virus type 1 (HIV-1)-specific immune responses elicited through vaccination are important considerations in the development of an effective HIV-1 vaccine. Responses to HIV-1 envelope subunit protein (Env) immunization in humans are often described as short-lived. METHODS: We enrolled 16 healthy volunteers who had received priming with an HIV-1 subtype B Env vaccine given with MF59 adjuvant 5-17 years previously and 20 healthy unprimed volunteers. Three booster immunizations with a heterologous subtype C trimeric gp140 protein vaccine were administered to the primed group, and the same subtype C gp140 protein vaccination regimen was administered to the unprimed subjects. RESULTS: Binding antibodies and neutralizing antibodies to tier 1 viral isolates were detected in the majority of previously primed subjects. Remarkably, a single dose of protein boosted binding and neutralizing antibody titers in 100% of primed subjects following this prolonged immunologic rest period, and CD4+ T-cell responses were boosted in 75% of primed individuals. CONCLUSIONS: These results demonstrate that HIV-1 protein immunogens can elicit durable memory T- and B-cell responses and that strong tier 1 virus neutralizing responses can be elicited by a single booster dose of protein following a long immunologic rest period. However, we found no evidence that cross-clade boosting led to a significantly broadened neutralizing antibody response.

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Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

May 5, 2019

Volume

219

Issue

11

Start / End Page

1755 / 1765

Location

United States

Related Subject Headings

  • Young Adult
  • Vaccination
  • Middle Aged
  • Microbiology
  • Immunization, Secondary
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Antibodies, Neutralizing
 

Citation

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Spearman, P., Tomaras, G. D., Montefiori, D. C., Huang, Y., Elizaga, M. L., Ferrari, G., … HVTN 088 Protocol Team and the NIH/NIAID HIV Vaccine Trials Network, . (2019). Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest Period. J Infect Dis, 219(11), 1755–1765. https://doi.org/10.1093/infdis/jiz008
Spearman, Paul, Georgia D. Tomaras, David C. Montefiori, Ying Huang, Marnie L. Elizaga, Guido Ferrari, S Munir Alam, et al. “Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest Period.J Infect Dis 219, no. 11 (May 5, 2019): 1755–65. https://doi.org/10.1093/infdis/jiz008.
Spearman P, Tomaras GD, Montefiori DC, Huang Y, Elizaga ML, Ferrari G, et al. Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest Period. J Infect Dis. 2019 May 5;219(11):1755–65.
Spearman, Paul, et al. “Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest Period.J Infect Dis, vol. 219, no. 11, May 2019, pp. 1755–65. Pubmed, doi:10.1093/infdis/jiz008.
Spearman P, Tomaras GD, Montefiori DC, Huang Y, Elizaga ML, Ferrari G, Alam SM, Isaacs A, Ahmed H, Hural J, McElrath MJ, Ouedraogo L, Pensiero M, Butler C, Kalams SA, Overton ET, Barnett SW, HVTN 088 Protocol Team and the NIH/NIAID HIV Vaccine Trials Network. Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest Period. J Infect Dis. 2019 May 5;219(11):1755–1765.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

May 5, 2019

Volume

219

Issue

11

Start / End Page

1755 / 1765

Location

United States

Related Subject Headings

  • Young Adult
  • Vaccination
  • Middle Aged
  • Microbiology
  • Immunization, Secondary
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Antibodies, Neutralizing