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Risk of development of treated retinopathy of prematurity in very low birth weight infants.

Publication ,  Journal Article
Gonski, S; Hupp, SR; Cotten, CM; Clark, RH; Laughon, M; Watt, K; Hornik, CP; Kumar, K; Smith, PB; Greenberg, RG
Published in: J Perinatol
November 2019

OBJECTIVE: Quantify the risk of treatment for retinopathy of prematurity (ROP) among infants meeting current U.S. screening guidelines. STUDY DESIGN: Among infants ≤1500 g birth weight or ≤30 weeks gestation screened for ROP from 2006-2015, we developed a risk prediction model to identify infants treated for ROP. We applied our model to a separate infant cohort discharged in 2016. RESULT: Seventy-five thousand eight hundred and twenty one infants met inclusion criteria; 2306 (3%) were treated for ROP. Infants with several risk factor combinations (no ventilator support or oxygen on postnatal day 28, no history of necrotizing enterocolitis, and no intraventricular hemorrhage) were at low risk of ROP. Applied to 6127 infants discharged in 2016, our model had 97.9% sensitivity, 63.3% specificity, positive predictive value of 4.0%, and negative predictive value of 99.9%. CONCLUSION: Large numbers of infants at low risk of developing ROP are required to undergo screening. Refining current ROP guidelines may reduce unnecessary examinations.

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

November 2019

Volume

39

Issue

11

Start / End Page

1562 / 1568

Location

United States

Related Subject Headings

  • Weight Gain
  • United States
  • Sensitivity and Specificity
  • Risk Factors
  • Risk Assessment
  • Retinopathy of Prematurity
  • Pediatrics
  • Neonatal Screening
  • Male
  • Logistic Models
 

Citation

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Gonski, S., Hupp, S. R., Cotten, C. M., Clark, R. H., Laughon, M., Watt, K., … Greenberg, R. G. (2019). Risk of development of treated retinopathy of prematurity in very low birth weight infants. J Perinatol, 39(11), 1562–1568. https://doi.org/10.1038/s41372-019-0487-6
Gonski, Samantha, Susan R. Hupp, C Michael Cotten, Reese H. Clark, Matthew Laughon, Kevin Watt, Christoph P. Hornik, Karan Kumar, P Brian Smith, and Rachel G. Greenberg. “Risk of development of treated retinopathy of prematurity in very low birth weight infants.J Perinatol 39, no. 11 (November 2019): 1562–68. https://doi.org/10.1038/s41372-019-0487-6.
Gonski S, Hupp SR, Cotten CM, Clark RH, Laughon M, Watt K, et al. Risk of development of treated retinopathy of prematurity in very low birth weight infants. J Perinatol. 2019 Nov;39(11):1562–8.
Gonski, Samantha, et al. “Risk of development of treated retinopathy of prematurity in very low birth weight infants.J Perinatol, vol. 39, no. 11, Nov. 2019, pp. 1562–68. Pubmed, doi:10.1038/s41372-019-0487-6.
Gonski S, Hupp SR, Cotten CM, Clark RH, Laughon M, Watt K, Hornik CP, Kumar K, Smith PB, Greenberg RG. Risk of development of treated retinopathy of prematurity in very low birth weight infants. J Perinatol. 2019 Nov;39(11):1562–1568.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

November 2019

Volume

39

Issue

11

Start / End Page

1562 / 1568

Location

United States

Related Subject Headings

  • Weight Gain
  • United States
  • Sensitivity and Specificity
  • Risk Factors
  • Risk Assessment
  • Retinopathy of Prematurity
  • Pediatrics
  • Neonatal Screening
  • Male
  • Logistic Models