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Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia.

Publication ,  Journal Article
Brumbaugh, JE; Bell, EF; Grey, SF; DeMauro, SB; Vohr, BR; Harmon, HM; Bann, CM; Rysavy, MA; Logan, JW; Colaizy, TT; Peralta-Carcelen, MA ...
Published in: J Pediatr
April 2020

OBJECTIVE: To characterize behavior of 2-year-old children based on the severity of bronchopulmonary dysplasia (BPD). STUDY DESIGN: We studied children born at 22-26 weeks of gestation and assessed at 22-26 months of corrected age with the Child Behavior Checklist (CBCL). BPD was classified by the level of respiratory support at 36 weeks of postmenstrual age. CBCL syndrome scales were the primary outcomes. The relationship between BPD grade and behavior was evaluated, adjusting for perinatal confounders. Mediation analysis was performed to evaluate whether cognitive, language, or motor skills mediated the effect of BPD grade on behavior. RESULTS: Of 2310 children, 1208 (52%) had no BPD, 806 (35%) had grade 1 BPD, 177 (8%) had grade 2 BPD, and 119 (5%) had grade 3 BPD. Withdrawn behavior (P < .001) and pervasive developmental problems (P < .001) increased with worsening BPD grade. Sleep problems (P = .008) and aggressive behavior (P = .023) decreased with worsening BPD grade. Children with grade 3 BPD scored 2 points worse for withdrawn behavior and pervasive developmental problems and 2 points better for externalizing problems, sleep problems, and aggressive behavior than children without BPD. Cognitive, language, and motor skills mediated the effect of BPD grade on the attention problems, emotionally reactive, somatic complaints, and withdrawn CBCL syndrome scales (P values < .05). CONCLUSIONS: BPD grade was associated with increased risk of withdrawn behavior and pervasive developmental problems but with decreased risk of sleep problems and aggressive behavior. The relationship between BPD and behavior is complex. Cognitive, language, and motor skills mediate the effects of BPD grade on some problem behaviors.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

April 2020

Volume

219

Start / End Page

152 / 159.e5

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Prospective Studies
  • Problem Behavior
  • Pediatrics
  • Motor Skills
  • Male
  • Language Development
  • Infant, Newborn
  • Infant, Extremely Premature
  • Infant Behavior
 

Citation

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Brumbaugh, J. E., Bell, E. F., Grey, S. F., DeMauro, S. B., Vohr, B. R., Harmon, H. M., … Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . (2020). Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia. J Pediatr, 219, 152-159.e5. https://doi.org/10.1016/j.jpeds.2019.12.028
Brumbaugh, Jane E., Edward F. Bell, Scott F. Grey, Sara B. DeMauro, Betty R. Vohr, Heidi M. Harmon, Carla M. Bann, et al. “Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia.J Pediatr 219 (April 2020): 152-159.e5. https://doi.org/10.1016/j.jpeds.2019.12.028.
Brumbaugh JE, Bell EF, Grey SF, DeMauro SB, Vohr BR, Harmon HM, et al. Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia. J Pediatr. 2020 Apr;219:152-159.e5.
Brumbaugh, Jane E., et al. “Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia.J Pediatr, vol. 219, Apr. 2020, pp. 152-159.e5. Pubmed, doi:10.1016/j.jpeds.2019.12.028.
Brumbaugh JE, Bell EF, Grey SF, DeMauro SB, Vohr BR, Harmon HM, Bann CM, Rysavy MA, Logan JW, Colaizy TT, Peralta-Carcelen MA, McGowan EC, Duncan AF, Stoll BJ, Das A, Hintz SR, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia. J Pediatr. 2020 Apr;219:152-159.e5.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

April 2020

Volume

219

Start / End Page

152 / 159.e5

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Prospective Studies
  • Problem Behavior
  • Pediatrics
  • Motor Skills
  • Male
  • Language Development
  • Infant, Newborn
  • Infant, Extremely Premature
  • Infant Behavior