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Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer's Disease in a Mouse Model.

Publication ,  Journal Article
Song, G; Steelman, ZA; Finkelstein, S; Yang, Z; Martin, L; Chu, KK; Farsiu, S; Arshavsky, VY; Wax, A
Published in: Sci Rep
May 13, 2020

We acquired depth-resolved light scattering measurements from the retinas of triple transgenic Alzheimer's Disease (3xTg-AD) mice and wild type (WT) age-matched controls using co-registered angle-resolved low-coherence interferometry (a/LCI) and optical coherence tomography (OCT). Angle-resolved light scattering measurements were acquired from the nerve fiber layer, outer plexiform layer, and retinal pigmented epithelium using image guidance and segmented thicknesses provided by co-registered OCT B-scans. Analysis of the OCT images showed a statistically significant thinning of the nerve fiber layer in AD mouse retinas compared to WT controls. The a/LCI scattering measurements provided complementary information that distinguishes AD mice by quantitatively characterizing tissue heterogeneity. The AD mouse retinas demonstrated higher mean and variance in nerve fiber layer light scattering intensity compared to WT controls. Further, the difference in tissue heterogeneity was observed through short-range spatial correlations that show greater slopes at all layers of interest for AD mouse retinas compared to WT controls. A greater slope indicates a faster loss of spatial correlation, suggesting a loss of tissue self-similarity characteristic of heterogeneity consistent with AD pathology. Use of this combined modality introduces unique tissue texture characterization to complement development of future AD biomarker analysis.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

May 13, 2020

Volume

10

Issue

1

Start / End Page

7912

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Signal Processing, Computer-Assisted
  • Retina
  • Mice, Transgenic
  • Mice
  • Image Processing, Computer-Assisted
  • Fluorescent Antibody Technique
  • Disease Models, Animal
  • Biopsy
  • Biomarkers
 

Citation

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Chicago
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Song, G., Steelman, Z. A., Finkelstein, S., Yang, Z., Martin, L., Chu, K. K., … Wax, A. (2020). Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer's Disease in a Mouse Model. Sci Rep, 10(1), 7912. https://doi.org/10.1038/s41598-020-64827-2
Song, Ge, Zachary A. Steelman, Stella Finkelstein, Ziyun Yang, Ludovic Martin, Kengyeh K. Chu, Sina Farsiu, Vadim Y. Arshavsky, and Adam Wax. “Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer's Disease in a Mouse Model.Sci Rep 10, no. 1 (May 13, 2020): 7912. https://doi.org/10.1038/s41598-020-64827-2.
Song G, Steelman ZA, Finkelstein S, Yang Z, Martin L, Chu KK, et al. Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer's Disease in a Mouse Model. Sci Rep. 2020 May 13;10(1):7912.
Song, Ge, et al. “Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer's Disease in a Mouse Model.Sci Rep, vol. 10, no. 1, May 2020, p. 7912. Pubmed, doi:10.1038/s41598-020-64827-2.
Song G, Steelman ZA, Finkelstein S, Yang Z, Martin L, Chu KK, Farsiu S, Arshavsky VY, Wax A. Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer's Disease in a Mouse Model. Sci Rep. 2020 May 13;10(1):7912.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

May 13, 2020

Volume

10

Issue

1

Start / End Page

7912

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Signal Processing, Computer-Assisted
  • Retina
  • Mice, Transgenic
  • Mice
  • Image Processing, Computer-Assisted
  • Fluorescent Antibody Technique
  • Disease Models, Animal
  • Biopsy
  • Biomarkers