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Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.

Publication ,  Journal Article
Om, K; Paquin-Proulx, D; Montero, M; Peachman, K; Shen, X; Wieczorek, L; Beck, Z; Weiner, JA; Kim, D; Li, Y; Mdluli, T; Shubin, Z; Bryant, C ...
Published in: PLoS Pathog
September 2020

To augment HIV-1 pox-protein vaccine immunogenicity using a next generation adjuvant, a prime-boost strategy of recombinant modified vaccinia virus Ankara and multimeric Env gp145 was evaluated in macaques with either aluminum (alum) or a novel liposomal monophosphoryl lipid A (MPLA) formulation adsorbed to alum, ALFA. Binding antibody responses were robust and comparable between arms, while antibody-dependent neutrophil and monocyte phagocytotic responses were greatly enhanced by ALFA. Per-exposure vaccine efficacy against heterologous tier 2 SHIV mucosal challenge was 90% in ALFA-adjuvanted males (P = 0.002), while alum conferred no protection. Half of the ALFA-adjuvanted males remained uninfected after the full challenge series, which spanned seven months after the last vaccination. Antibody-dependent monocyte and neutrophil phagocytic responses both strongly correlated with protection. Significant sex differences in infection risk were observed, with much lower infection rates in females than males. In humans, MPLA-liposome-alum adjuvanted gp120 also increased HIV-1-specific phagocytic responses relative to alum. Thus, next-generation liposome-based adjuvants can drive vaccine elicited antibody effector activity towards potent phagocytic responses in both macaques and humans and these responses correlate with protection. Future protein vaccination strategies aiming to improve functional humoral responses may benefit from such adjuvants.

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Published In

PLoS Pathog

DOI

EISSN

1553-7374

Publication Date

September 2020

Volume

16

Issue

9

Start / End Page

e1008764

Location

United States

Related Subject Headings

  • Young Adult
  • Virology
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Middle Aged
  • Male
  • Macaca mulatta
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Om, K., Paquin-Proulx, D., Montero, M., Peachman, K., Shen, X., Wieczorek, L., … Bolton, D. L. (2020). Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge. PLoS Pathog, 16(9), e1008764. https://doi.org/10.1371/journal.ppat.1008764
Om, Kier, Dominic Paquin-Proulx, Maria Montero, Kristina Peachman, Xiaoying Shen, Lindsay Wieczorek, Zoltan Beck, et al. “Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.PLoS Pathog 16, no. 9 (September 2020): e1008764. https://doi.org/10.1371/journal.ppat.1008764.
Om K, Paquin-Proulx D, Montero M, Peachman K, Shen X, Wieczorek L, et al. Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge. PLoS Pathog. 2020 Sep;16(9):e1008764.
Om, Kier, et al. “Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.PLoS Pathog, vol. 16, no. 9, Sept. 2020, p. e1008764. Pubmed, doi:10.1371/journal.ppat.1008764.
Om K, Paquin-Proulx D, Montero M, Peachman K, Shen X, Wieczorek L, Beck Z, Weiner JA, Kim D, Li Y, Mdluli T, Shubin Z, Bryant C, Sharma V, Tokarev A, Dawson P, White Y, Appelbe O, Klatt NR, Tovanabutra S, Estes JD, Matyas GR, Ferrari G, Alving CR, Tomaras GD, Ackerman ME, Michael NL, Robb ML, Polonis V, Rolland M, Eller MA, Rao M, Bolton DL. Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge. PLoS Pathog. 2020 Sep;16(9):e1008764.

Published In

PLoS Pathog

DOI

EISSN

1553-7374

Publication Date

September 2020

Volume

16

Issue

9

Start / End Page

e1008764

Location

United States

Related Subject Headings

  • Young Adult
  • Virology
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Middle Aged
  • Male
  • Macaca mulatta
  • Humans