Skip to main content

Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study.

Publication ,  Journal Article
Gupta, A; Oyekunle, T; Salako, O; Daramola, A; Alatise, O; Ogun, G; Adeniyi, A; Deveaux, A; Saraiya, V; Hall, A; Ayandipo, O; Olajide, T ...
Published in: Oncotarget
June 22, 2021

Breast cancer (BC) in Nigeria is characterized by disproportionately aggressive molecular subtypes. C-reactive protein (CRP) is associated with risk and aggressiveness for several types of cancer. We examined the association of high-sensitivity CRP (hsCRP) with odds of BC by molecular subtype among Nigerian women. Among 296 newly diagnosed BC cases and 259 healthy controls, multivariable logistic regression models were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the association between hsCRP and odds of BC overall and by molecular subtype (luminal A, luminal B, HER2-enriched and triple-negative or TNBC). High hsCRP (> 3 mg/L) was observed in 57% of cases and 31% of controls and was associated with 4 times the odds of BC (aOR: 4.43; 95% CI: 2.56, 7.66) after adjusting for socio-demographic, reproductive, and clinical variables. This association persisted regardless of menopausal status and body mass index (BMI) category. High hsCRP was associated with increased odds of TNBC (aOR: 3.32; 95% CI: 1.07, 10.35), luminal A BC (aOR: 4.03; 95% CI: 1.29, 12.64), and HER2-enriched BC (aOR: 6.27; 95% CI: 1.69, 23.25). Future studies are necessary in this population to further evaluate a potential role for CRP as a predictive biomarker for BC.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

June 22, 2021

Volume

12

Issue

13

Start / End Page

1230 / 1242

Location

United States

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gupta, A., Oyekunle, T., Salako, O., Daramola, A., Alatise, O., Ogun, G., … Akinyemiju, T. (2021). Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study. Oncotarget, 12(13), 1230–1242. https://doi.org/10.18632/oncotarget.27991
Gupta, Anjali, Taofik Oyekunle, Omolola Salako, Adetola Daramola, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, et al. “Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study.Oncotarget 12, no. 13 (June 22, 2021): 1230–42. https://doi.org/10.18632/oncotarget.27991.
Gupta A, Oyekunle T, Salako O, Daramola A, Alatise O, Ogun G, et al. Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study. Oncotarget. 2021 Jun 22;12(13):1230–42.
Gupta, Anjali, et al. “Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study.Oncotarget, vol. 12, no. 13, June 2021, pp. 1230–42. Pubmed, doi:10.18632/oncotarget.27991.
Gupta A, Oyekunle T, Salako O, Daramola A, Alatise O, Ogun G, Adeniyi A, Deveaux A, Saraiya V, Hall A, Ayandipo O, Olajide T, Olasehinde O, Arowolo O, Adisa A, Afuwape O, Olusanya A, Adegoke A, Tollefsbol TO, Arnett D, Muehlbauer MJ, Newgard CB, H3 Africa Kidney Research Network, Akinyemiju T. Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study. Oncotarget. 2021 Jun 22;12(13):1230–1242.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

June 22, 2021

Volume

12

Issue

13

Start / End Page

1230 / 1242

Location

United States

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis