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Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats.

Publication ,  Journal Article
Levin, ED; Wells, C; Slade, S; Johnson, J; Petro, A; Rezvani, AH; Rose, JE
Published in: Behav Brain Res
January 7, 2022

The habenula is an epithalamic structure through which descending connections go from the telencephalon to the brainstem, putting it in a key location to provide feedback control over the ascending projections from the brainstem to the telencephalon. The medial habenula has a high concentration of nicotinic receptors. We assessed the role of medial habenular nicotinic receptors for nicotine self-administration (SA) in female young adult Sprague-Dawley rats. The rats had bilateral chronic infusion cannulae placed into the medial habenula nucleus. Each cannula was connected to a slow delivery osmotic minipump to chronically infuse mecamylamine (100 µg/side/day) or vehicle for four consecutive weeks. The rats were tested for nicotine SA for the first two weeks of mecamylamine infusion. Then, they had one week of enforced abstinence, during which they had no access to the nicotine SA. Finally, they had one week of resumed nicotine SA access. There was a significantly differential mecamylamine effects in animals with lower and higher pretreatment baseline nicotine SA. Rats with lower baseline nicotine SA levels showed a nearly significant mecamylamine-induced reduction in SA while those with higher baseline levels of SA showed a significant mecamylamine-induced increase in nicotine SA. This study determined that medial habenular nicotinic receptors are important for nicotine reinforcement. Baseline level of performance makes a crucial difference for the involvement of habenular mechanisms in nicotine reinforcement with nicotinic activation being important for maintaining nicotine self-administration for those with lower levels of baseline self-administration and the opposite effect with subjects with higher levels of baseline self-administration.

Duke Scholars

Published In

Behav Brain Res

DOI

EISSN

1872-7549

Publication Date

January 7, 2022

Volume

416

Start / End Page

113574

Location

Netherlands

Related Subject Headings

  • Self Administration
  • Reinforcement, Psychology
  • Receptors, Nicotinic
  • Rats, Sprague-Dawley
  • Rats
  • Nicotine
  • Neurology & Neurosurgery
  • Mecamylamine
  • Infusions, Intraventricular
  • Habenula
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Levin, E. D., Wells, C., Slade, S., Johnson, J., Petro, A., Rezvani, A. H., & Rose, J. E. (2022). Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats. Behav Brain Res, 416, 113574. https://doi.org/10.1016/j.bbr.2021.113574
Levin, Edward D., Corinne Wells, Susan Slade, Joshua Johnson, Ann Petro, Amir H. Rezvani, and Jed E. Rose. “Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats.Behav Brain Res 416 (January 7, 2022): 113574. https://doi.org/10.1016/j.bbr.2021.113574.
Levin ED, Wells C, Slade S, Johnson J, Petro A, Rezvani AH, et al. Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats. Behav Brain Res. 2022 Jan 7;416:113574.
Levin, Edward D., et al. “Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats.Behav Brain Res, vol. 416, Jan. 2022, p. 113574. Pubmed, doi:10.1016/j.bbr.2021.113574.
Levin ED, Wells C, Slade S, Johnson J, Petro A, Rezvani AH, Rose JE. Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats. Behav Brain Res. 2022 Jan 7;416:113574.
Journal cover image

Published In

Behav Brain Res

DOI

EISSN

1872-7549

Publication Date

January 7, 2022

Volume

416

Start / End Page

113574

Location

Netherlands

Related Subject Headings

  • Self Administration
  • Reinforcement, Psychology
  • Receptors, Nicotinic
  • Rats, Sprague-Dawley
  • Rats
  • Nicotine
  • Neurology & Neurosurgery
  • Mecamylamine
  • Infusions, Intraventricular
  • Habenula