Skip to main content
Journal cover image

Association of body composition with odds of breast cancer by molecular subtype: analysis of the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study.

Publication ,  Journal Article
Akinyemiju, T; Jones, K; Gupta, A; Oyekunle, T; Saraiya, V; Deveaux, A; Salako, O; Hall, A; Alatise, O; Ogun, G; Adeniyi, A; Ayandipo, O ...
Published in: BMC Cancer
September 25, 2021

BACKGROUND: The association between obesity and breast cancer (BC) has been extensively studied among US, European and Asian study populations, with often conflicting evidence. However, despite the increasing prevalence of obesity and associated conditions in Africa, the continent with the highest age-standardized BC mortality rate globally, few studies have evaluated this association, and none has examined in relation to molecular subtypes among African women. The current analysis examines the association between body composition, defined by body mass index (BMI), height, and weight, and BC by molecular subtype among African women. METHODS: We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association between measures of body composition and BC and molecular subtypes among 419 histologically confirmed cases of BC and 286 healthy controls from the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Women of Nigerian Descent (MEND) case-control study. RESULTS: Higher BMI (aOR: 0.79; 95% CI: 0.67, 0.95) and weight (aOR: 0.83; 95% CI: 0.69, 0.98) were associated with reduced odds of BC in adjusted models, while height was associated with non-statistically significant increased odds of BC (aOR: 1.07, 95% CI: 0.90, 1.28). In pre/peri-menopausal, but not post-menopausal women, both higher BMI and weight were significantly associated with reduced odds of BC. Further, higher BMI was associated with reduced odds of Luminal A, Luminal B, and HER2-enriched BC among pre/peri-menopausal women, and reduced odds of triple-negative BC among post-menopausal women. CONCLUSIONS: Higher BMI and weight were associated with reduced odds of BC overall and by molecular subtype among West African women. Larger studies of women of African descent are needed to definitively characterize these associations and inform cancer prevention strategies.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

BMC Cancer

DOI

EISSN

1471-2407

Publication Date

September 25, 2021

Volume

21

Issue

1

Start / End Page

1051

Location

England

Related Subject Headings

  • Triple Negative Breast Neoplasms
  • Risk Factors
  • Reproductive History
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Nigeria
  • Middle Aged
  • Menopause
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Akinyemiju, T., Jones, K., Gupta, A., Oyekunle, T., Saraiya, V., Deveaux, A., … Daramola, A. (2021). Association of body composition with odds of breast cancer by molecular subtype: analysis of the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study. BMC Cancer, 21(1), 1051. https://doi.org/10.1186/s12885-021-08775-8
Akinyemiju, Tomi, Kelley Jones, Anjali Gupta, Taofik Oyekunle, Veeral Saraiya, April Deveaux, Omolola Salako, et al. “Association of body composition with odds of breast cancer by molecular subtype: analysis of the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study.BMC Cancer 21, no. 1 (September 25, 2021): 1051. https://doi.org/10.1186/s12885-021-08775-8.
Akinyemiju T, Jones K, Gupta A, Oyekunle T, Saraiya V, Deveaux A, Salako O, Hall A, Alatise O, Ogun G, Adeniyi A, Ayandipo O, Olajide T, Olasehinde O, Arowolo O, Adisa A, Afuwape O, Olusanya A, Adegoke A, Tollefsbol TO, Arnett D, H3 Africa Kidney Research Network, Daramola A. Association of body composition with odds of breast cancer by molecular subtype: analysis of the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study. BMC Cancer. 2021 Sep 25;21(1):1051.
Journal cover image

Published In

BMC Cancer

DOI

EISSN

1471-2407

Publication Date

September 25, 2021

Volume

21

Issue

1

Start / End Page

1051

Location

England

Related Subject Headings

  • Triple Negative Breast Neoplasms
  • Risk Factors
  • Reproductive History
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Nigeria
  • Middle Aged
  • Menopause
  • Humans
  • Female