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Self-administration by female rats of low doses of nicotine alone vs. nicotine in tobacco smoke extract.

Publication ,  Journal Article
Levin, ED; Wells, C; Pace, C; Abass, G; Hawkey, A; Holloway, Z; Rezvani, AH; Rose, JE
Published in: Drug Alcohol Depend
November 1, 2021

BACKGROUND: Nicotine has reinforcing effects, but there are thousands of other compounds in tobacco, some of which might interact with nicotine reinforcement. AIMS: This rat study was conducted to determine if nicotine self-administration is altered by co-administration of the complex mixture of compounds in tobacco smoke extract (TSE). METHODS: Female Sprague-Dawley rats were tested for self-administration of low doses of nicotine (3 or 10 µg/kg/infusion) at three different rates of reinforcement (FR1, FR3 and FR5) over three weeks either alone or together with the complex mixture of tobacco smoke extract (TSE). RESULTS: Rats self-administering 3 µg/kg/infusion of nicotine alone showed a rapid initiation on an FR1 schedule, but declined with FR5. Rats self-administering nicotine in TSE acquired self-administration more slowly, but increased responding over the course of the study. With 10 µg/kg/infusion rats self-administered significantly more nicotine alone than rats self-administering the same nicotine dose in TSE. Rats self-administering nicotine alone took significantly more infusions with the 10 than the 3 µg/kg/infusion dose, whereas rats self-administering nicotine in TSE did not. Nicotine in TSE led to a significantly greater locomotor hyperactivity at a dose of 0.1 mg/kg compared to rats that received nicotine alone. Rats self-administering nicotine alone had significantly more responding on the active vs. inactive lever, but rats self-administering the same nicotine doses in TSE did not. CONCLUSIONS: Self-administration of nicotine in a purer form appears to be more clearly discriminated and dose-related than nicotine self-administered in the complex mixture of TSE.

Duke Scholars

Published In

Drug Alcohol Depend

DOI

EISSN

1879-0046

Publication Date

November 1, 2021

Volume

228

Start / End Page

109073

Location

Ireland

Related Subject Headings

  • Tobacco Smoke Pollution
  • Substance Abuse
  • Smoke
  • Self Administration
  • Rats, Sprague-Dawley
  • Rats
  • Nicotine
  • Nicotiana
  • Female
  • Dose-Response Relationship, Drug
 

Citation

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Levin, E. D., Wells, C., Pace, C., Abass, G., Hawkey, A., Holloway, Z., … Rose, J. E. (2021). Self-administration by female rats of low doses of nicotine alone vs. nicotine in tobacco smoke extract. Drug Alcohol Depend, 228, 109073. https://doi.org/10.1016/j.drugalcdep.2021.109073
Levin, Edward D., Corinne Wells, Caroline Pace, Grant Abass, Andrew Hawkey, Zade Holloway, Amir H. Rezvani, and Jed E. Rose. “Self-administration by female rats of low doses of nicotine alone vs. nicotine in tobacco smoke extract.Drug Alcohol Depend 228 (November 1, 2021): 109073. https://doi.org/10.1016/j.drugalcdep.2021.109073.
Levin ED, Wells C, Pace C, Abass G, Hawkey A, Holloway Z, et al. Self-administration by female rats of low doses of nicotine alone vs. nicotine in tobacco smoke extract. Drug Alcohol Depend. 2021 Nov 1;228:109073.
Levin, Edward D., et al. “Self-administration by female rats of low doses of nicotine alone vs. nicotine in tobacco smoke extract.Drug Alcohol Depend, vol. 228, Nov. 2021, p. 109073. Pubmed, doi:10.1016/j.drugalcdep.2021.109073.
Levin ED, Wells C, Pace C, Abass G, Hawkey A, Holloway Z, Rezvani AH, Rose JE. Self-administration by female rats of low doses of nicotine alone vs. nicotine in tobacco smoke extract. Drug Alcohol Depend. 2021 Nov 1;228:109073.
Journal cover image

Published In

Drug Alcohol Depend

DOI

EISSN

1879-0046

Publication Date

November 1, 2021

Volume

228

Start / End Page

109073

Location

Ireland

Related Subject Headings

  • Tobacco Smoke Pollution
  • Substance Abuse
  • Smoke
  • Self Administration
  • Rats, Sprague-Dawley
  • Rats
  • Nicotine
  • Nicotiana
  • Female
  • Dose-Response Relationship, Drug