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Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.

Publication ,  Journal Article
Peres, LC; Colin-Leitzinger, C; Sinha, S; Marks, JR; Conejo-Garcia, JR; Alberg, AJ; Bandera, EV; Berchuck, A; Bondy, ML; Christensen, BC ...
Published in: Cancer Epidemiol Biomarkers Prev
May 4, 2022

BACKGROUND: Tumor-infiltrating lymphocytes (TIL) confer a survival benefit among patients with ovarian cancer; however, little work has been conducted in racially diverse cohorts. METHODS: The current study investigated racial differences in the tumor immune landscape and survival of age- and stage-matched non-Hispanic Black and non-Hispanic White women with high-grade serous ovarian carcinoma (HGSOC) enrolled in two population-based studies (n = 121 in each racial group). We measured TILs (CD3+), cytotoxic T cells (CD3+CD8+), regulatory T cells (CD3+FoxP3+), myeloid cells (CD11b+), and neutrophils (CD11b+CD15+) via multiplex immunofluorescence. Multivariable Cox proportional hazard regression was used to estimate the association between immune cell abundance and survival overall and by race. RESULTS: Overall, higher levels of TILs, cytotoxic T cells, myeloid cells, and neutrophils were associated with better survival in the intratumoral and peritumoral region, irrespective of tissue compartment (tumor, stroma). Improved survival was noted for T-regulatory cells in the peritumoral region and in the stroma of the intratumoral region, but no association for intratumoral T-regulatory cells. Despite similar abundance of immune cells across racial groups, associations with survival among non-Hispanic White women were consistent with the overall findings, but among non-Hispanic Black women, most associations were attenuated and not statistically significant. CONCLUSIONS: Our results add to the existing evidence that a robust immune infiltrate confers a survival advantage among women with HGSOC; however, non-Hispanic Black women may not experience the same survival benefit as non-Hispanic White women with HGSOC. IMPACT: This study contributes to our understanding of the immunoepidemiology of HGSOC in diverse populations.

Duke Scholars

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

May 4, 2022

Volume

31

Issue

5

Start / End Page

1006 / 1016

Location

United States

Related Subject Headings

  • Race Factors
  • Ovarian Neoplasms
  • Male
  • Lymphocytes, Tumor-Infiltrating
  • Humans
  • Female
  • Ethnicity
  • Epidemiology
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

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MLA
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Peres, L. C., Colin-Leitzinger, C., Sinha, S., Marks, J. R., Conejo-Garcia, J. R., Alberg, A. J., … Schildkraut, J. M. (2022). Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma. Cancer Epidemiol Biomarkers Prev, 31(5), 1006–1016. https://doi.org/10.1158/1055-9965.EPI-21-1334
Peres, Lauren C., Christelle Colin-Leitzinger, Sweta Sinha, Jeffrey R. Marks, Jose R. Conejo-Garcia, Anthony J. Alberg, Elisa V. Bandera, et al. “Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.Cancer Epidemiol Biomarkers Prev 31, no. 5 (May 4, 2022): 1006–16. https://doi.org/10.1158/1055-9965.EPI-21-1334.
Peres LC, Colin-Leitzinger C, Sinha S, Marks JR, Conejo-Garcia JR, Alberg AJ, et al. Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma. Cancer Epidemiol Biomarkers Prev. 2022 May 4;31(5):1006–16.
Peres, Lauren C., et al. “Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.Cancer Epidemiol Biomarkers Prev, vol. 31, no. 5, May 2022, pp. 1006–16. Pubmed, doi:10.1158/1055-9965.EPI-21-1334.
Peres LC, Colin-Leitzinger C, Sinha S, Marks JR, Conejo-Garcia JR, Alberg AJ, Bandera EV, Berchuck A, Bondy ML, Christensen BC, Cote ML, Doherty JA, Moorman PG, Peters ES, Moran Segura C, Nguyen JV, Schwartz AG, Terry PD, Wilson CM, Fridley BL, Schildkraut JM. Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma. Cancer Epidemiol Biomarkers Prev. 2022 May 4;31(5):1006–1016.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

May 4, 2022

Volume

31

Issue

5

Start / End Page

1006 / 1016

Location

United States

Related Subject Headings

  • Race Factors
  • Ovarian Neoplasms
  • Male
  • Lymphocytes, Tumor-Infiltrating
  • Humans
  • Female
  • Ethnicity
  • Epidemiology
  • 42 Health sciences
  • 32 Biomedical and clinical sciences