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Association of left ventricular diastolic function with coronary artery calcium score: A Project Baseline Health Study.

Publication ,  Journal Article
Haddad, F; Cauwenberghs, N; Daubert, MA; Kobayashi, Y; Bloomfield, GS; Fleischman, D; Koweek, L; Maron, DJ; Rodriguez, F; Liao, YJ; Amsallem, M ...
Published in: J Cardiovasc Comput Tomogr
2022

BACKGROUND: Coronary artery calcium (CAC) and left ventricular diastolic dysfunction (LVDD) are strong predictors of cardiovascular events and share common risk factors. However, their independent association remains unclear. METHODS: In the Project Baseline Health Study (PBHS), 2082 participants underwent cardiac-gated, non-contrast chest computed tomography (CT) and echocardiography. The association between left ventricular (LV) diastolic function and CAC was assessed using multidimensional network and multivariable-adjusted regression analyses. Multivariable analysis was conducted on continuous LV diastolic parameters and categorical classification of LVDD and adjusted for traditional cardiometabolic risk factors. LVDD was defined using reference limits from a low-risk reference group without established cardiovascular disease, cardiovascular risk factors or evidence of CAC, (n ​= ​560). We also classified LVDD using the American Society of Echocardiography recommendations. RESULTS: The mean age of the participants was 51 ​± ​17 years with 56.6% female and 62.6% non-Hispanic White. Overall, 38.1% had hypertension; 13.7% had diabetes; and 39.9% had CAC >0. An intertwined network was observed between diastolic parameters, CAC score, age, LV mass index, and pulse pressure. In the multivariable-adjusted analysis, e', E/e', and LV mass index were independently associated with CAC after adjustment for traditional risk factors. For both e' and E/e', the effect size and statistical significance were higher across increasing CAC tertiles. Other independent correlates of e' and E/e' included age, female sex, Black race, height, weight, pulse pressure, hemoglobin A1C, and HDL cholesterol. The independent association with CAC was confirmed using categorical analysis of LVDD, which occurred in 554 participants (26.6%) using population-derived thresholds. CONCLUSION: In the PBHS study, the subclinical coronary atherosclerotic disease burden detected using CAC scoring was independently associated with diastolic function. GOV IDENTIFIER: NCT03154346.

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Published In

J Cardiovasc Comput Tomogr

DOI

EISSN

1876-861X

Publication Date

2022

Volume

16

Issue

6

Start / End Page

498 / 508

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Humans
  • Heart Ventricles
  • Female
  • Diastole
  • Coronary Artery Disease
 

Citation

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Haddad, F., Cauwenberghs, N., Daubert, M. A., Kobayashi, Y., Bloomfield, G. S., Fleischman, D., … Project Baseline Health Study Investigators. (2022). Association of left ventricular diastolic function with coronary artery calcium score: A Project Baseline Health Study. J Cardiovasc Comput Tomogr, 16(6), 498–508. https://doi.org/10.1016/j.jcct.2022.06.003
Haddad, Francois, Nicholas Cauwenberghs, Melissa A. Daubert, Yukari Kobayashi, Gerald S. Bloomfield, Dominik Fleischman, Lynne Koweek, et al. “Association of left ventricular diastolic function with coronary artery calcium score: A Project Baseline Health Study.J Cardiovasc Comput Tomogr 16, no. 6 (2022): 498–508. https://doi.org/10.1016/j.jcct.2022.06.003.
Haddad F, Cauwenberghs N, Daubert MA, Kobayashi Y, Bloomfield GS, Fleischman D, et al. Association of left ventricular diastolic function with coronary artery calcium score: A Project Baseline Health Study. J Cardiovasc Comput Tomogr. 2022;16(6):498–508.
Haddad, Francois, et al. “Association of left ventricular diastolic function with coronary artery calcium score: A Project Baseline Health Study.J Cardiovasc Comput Tomogr, vol. 16, no. 6, 2022, pp. 498–508. Pubmed, doi:10.1016/j.jcct.2022.06.003.
Haddad F, Cauwenberghs N, Daubert MA, Kobayashi Y, Bloomfield GS, Fleischman D, Koweek L, Maron DJ, Rodriguez F, Liao YJ, Moneghetti K, Amsallem M, Mega J, Hernandez A, Califf R, Mahaffey KW, Shah SH, Kuznetsova T, Douglas PS, Project Baseline Health Study Investigators. Association of left ventricular diastolic function with coronary artery calcium score: A Project Baseline Health Study. J Cardiovasc Comput Tomogr. 2022;16(6):498–508.
Journal cover image

Published In

J Cardiovasc Comput Tomogr

DOI

EISSN

1876-861X

Publication Date

2022

Volume

16

Issue

6

Start / End Page

498 / 508

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Humans
  • Heart Ventricles
  • Female
  • Diastole
  • Coronary Artery Disease