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Association between simulated ketamine exposures and oxygen saturations in children.

Publication ,  Journal Article
Commander, SJ; Gonzalez, D; Kumar, KR; Spears, T; Cohen-Wolkowiez, M; Zimmerman, KO; Lee, JH; Hornik, CP
Published in: Int J Pharmacokinet
February 2023

AIM: We performed a real-world data analysis to evaluate the relationship between simulated ketamine exposures and oxygen desaturation in children. MATERIALS & METHODS: A previously developed population pharmacokinetic model was used to simulate exposures and evaluate target attainment, as well as the association with oxygen desaturation in children ≤17 years treated with intravenous ketamine. RESULTS: In 2022 children, there was no significant association between simulated plasma ketamine concentrations and oxygen saturation; however, a higher cumulative area under the curve was associated with increased odds of progression to significant desaturation (<85%), though magnitude of effect was small. CONCLUSION: By leveraging a population pharmacokinetic model and real-world data, we confirmed there is no relationship between simulated ketamine plasma concentration and oxygen desaturation.

Duke Scholars

Published In

Int J Pharmacokinet

DOI

EISSN

2053-0854

Publication Date

February 2023

Volume

6

Issue

1

Start / End Page

IPK03

Location

England
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Commander, S. J., Gonzalez, D., Kumar, K. R., Spears, T., Cohen-Wolkowiez, M., Zimmerman, K. O., … Hornik, C. P. (2023). Association between simulated ketamine exposures and oxygen saturations in children. Int J Pharmacokinet, 6(1), IPK03. https://doi.org/10.4155/ipk-2022-0003
Commander, Sarah Jane, Daniel Gonzalez, Karan R. Kumar, Tracy Spears, Michael Cohen-Wolkowiez, Kanecia O. Zimmerman, Jan Hau Lee, and Christoph P. Hornik. “Association between simulated ketamine exposures and oxygen saturations in children.Int J Pharmacokinet 6, no. 1 (February 2023): IPK03. https://doi.org/10.4155/ipk-2022-0003.
Commander SJ, Gonzalez D, Kumar KR, Spears T, Cohen-Wolkowiez M, Zimmerman KO, et al. Association between simulated ketamine exposures and oxygen saturations in children. Int J Pharmacokinet. 2023 Feb;6(1):IPK03.
Commander, Sarah Jane, et al. “Association between simulated ketamine exposures and oxygen saturations in children.Int J Pharmacokinet, vol. 6, no. 1, Feb. 2023, p. IPK03. Pubmed, doi:10.4155/ipk-2022-0003.
Commander SJ, Gonzalez D, Kumar KR, Spears T, Cohen-Wolkowiez M, Zimmerman KO, Lee JH, Hornik CP. Association between simulated ketamine exposures and oxygen saturations in children. Int J Pharmacokinet. 2023 Feb;6(1):IPK03.
Journal cover image

Published In

Int J Pharmacokinet

DOI

EISSN

2053-0854

Publication Date

February 2023

Volume

6

Issue

1

Start / End Page

IPK03

Location

England