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Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review.

Publication ,  Journal Article
Doernberg, SB; Arias, CA; Altman, DR; Babiker, A; Boucher, HW; Creech, CB; Cosgrove, SE; Evans, SR; Fowler, VG; Fritz, SA; Hamasaki, T; Liu, C ...
Published in: Clin Infect Dis
October 16, 2023

The Antibacterial Resistance Leadership Group (ARLG) has prioritized infections caused by gram-positive bacteria as one of its core areas of emphasis. The ARLG Gram-positive Committee has focused on studies responding to 3 main identified research priorities: (1) investigation of strategies or therapies for infections predominantly caused by gram-positive bacteria, (2) evaluation of the efficacy of novel agents for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci, and (3) optimization of dosing and duration of antimicrobial agents for gram-positive infections. Herein, we summarize ARLG accomplishments in gram-positive bacterial infection research, including studies aiming to (1) inform optimal vancomycin dosing, (2) determine the role of dalbavancin in MRSA bloodstream infection, (3) characterize enterococcal bloodstream infections, (4) demonstrate the benefits of short-course therapy for pediatric community-acquired pneumonia, (5) develop quality of life measures for use in clinical trials, and (6) advance understanding of the microbiome. Future studies will incorporate innovative methodologies with a focus on interventional clinical trials that have the potential to change clinical practice for difficult-to-treat infections, such as MRSA bloodstream infections.

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Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

October 16, 2023

Volume

77

Issue

Suppl 4

Start / End Page

S295 / S304

Location

United States

Related Subject Headings

  • Sepsis
  • Quality of Life
  • Microbiology
  • Methicillin-Resistant Staphylococcus aureus
  • Leadership
  • Humans
  • Gram-Positive Bacterial Infections
  • Gram-Positive Bacteria
  • Child
  • Anti-Bacterial Agents
 

Citation

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Doernberg, S. B., Arias, C. A., Altman, D. R., Babiker, A., Boucher, H. W., Creech, C. B., … Antibacterial Resistance Leadership Group, . (2023). Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review. Clin Infect Dis, 77(Suppl 4), S295–S304. https://doi.org/10.1093/cid/ciad565
Doernberg, Sarah B., Cesar A. Arias, Deena R. Altman, Ahmed Babiker, Helen W. Boucher, C Buddy Creech, Sara E. Cosgrove, et al. “Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review.Clin Infect Dis 77, no. Suppl 4 (October 16, 2023): S295–304. https://doi.org/10.1093/cid/ciad565.
Doernberg SB, Arias CA, Altman DR, Babiker A, Boucher HW, Creech CB, et al. Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review. Clin Infect Dis. 2023 Oct 16;77(Suppl 4):S295–304.
Doernberg, Sarah B., et al. “Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review.Clin Infect Dis, vol. 77, no. Suppl 4, Oct. 2023, pp. S295–304. Pubmed, doi:10.1093/cid/ciad565.
Doernberg SB, Arias CA, Altman DR, Babiker A, Boucher HW, Creech CB, Cosgrove SE, Evans SR, Fowler VG, Fritz SA, Hamasaki T, Kelly BJ, Leal SM, Liu C, Lodise TP, Miller LG, Munita JM, Murray BE, Pettigrew MM, Ruffin F, Scheetz MH, Shopsin B, Tran TT, Turner NA, Williams DJ, Zaharoff S, Holland TL, Antibacterial Resistance Leadership Group. Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review. Clin Infect Dis. 2023 Oct 16;77(Suppl 4):S295–S304.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

October 16, 2023

Volume

77

Issue

Suppl 4

Start / End Page

S295 / S304

Location

United States

Related Subject Headings

  • Sepsis
  • Quality of Life
  • Microbiology
  • Methicillin-Resistant Staphylococcus aureus
  • Leadership
  • Humans
  • Gram-Positive Bacterial Infections
  • Gram-Positive Bacteria
  • Child
  • Anti-Bacterial Agents