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Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions.

Publication ,  Journal Article
Thaker, VV; Kwee, LC; Chen, H; Bahnson, J; Ilkayeva, O; Muehlbauer, MJ; Wolfe, B; Purnell, JQ; Pi-Sunyer, X; Newgard, CB; Shah, SH ...
Published in: Obesity (Silver Spring)
February 2024

OBJECTIVE: This observational study investigated metabolomic changes in individuals with type 2 diabetes (T2D) after weight loss. We hypothesized that metabolite changes associated with T2D-relevant phenotypes are signatures of improved health. METHODS: Fasting plasma samples from individuals undergoing bariatric surgery (n = 71 Roux-en-Y gastric bypass [RYGB], n = 22 gastric banding), lifestyle intervention (n = 66), or usual care (n = 14) were profiled for 139 metabolites before and 2 years after weight loss. Principal component analysis grouped correlated metabolites into factors. Association of preintervention metabolites was tested with preintervention clinical features and changes in T2D markers. Association between change in metabolites/metabolite factors and change in T2D remission markers, homeostasis model assessment of β-cell function, homeostasis model assessment of insulin resistance, and glycated hemoglobin (HbA1c) was assessed. RESULTS: Branched-chain amino acids (BCAAs) were associated with preintervention adiposity. Changes in BCAAs (valine, leucine/isoleucine) and branched-chain ketoacids were positively associated with change in HbA1c (false discovery rate q value ≤ 0.001) that persisted after adjustment for percentage weight change and RYGB (p ≤ 0.02). In analyses stratified by RYGB or other weight loss method, some metabolites showed association with non-RYGB weight loss. CONCLUSIONS: This study confirmed known metabolite associations with obesity/T2D and showed an association of BCAAs with HbA1c change after weight loss, independent of the method or magnitude of weight loss.

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Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

February 2024

Volume

32

Issue

2

Start / End Page

304 / 314

Location

United States

Related Subject Headings

  • Weight Loss
  • Obesity, Morbid
  • Obesity
  • Humans
  • Glycated Hemoglobin
  • Gastric Bypass
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 2
  • Amino Acids, Branched-Chain
 

Citation

APA
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Thaker, V. V., Kwee, L. C., Chen, H., Bahnson, J., Ilkayeva, O., Muehlbauer, M. J., … Look AHEAD Research Group, . (2024). Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions. Obesity (Silver Spring), 32(2), 304–314. https://doi.org/10.1002/oby.23943
Thaker, Vidhu V., Lydia Coulter Kwee, Haiying Chen, Judy Bahnson, Olga Ilkayeva, Michael J. Muehlbauer, Bruce Wolfe, et al. “Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions.Obesity (Silver Spring) 32, no. 2 (February 2024): 304–14. https://doi.org/10.1002/oby.23943.
Thaker VV, Kwee LC, Chen H, Bahnson J, Ilkayeva O, Muehlbauer MJ, et al. Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions. Obesity (Silver Spring). 2024 Feb;32(2):304–14.
Thaker, Vidhu V., et al. “Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions.Obesity (Silver Spring), vol. 32, no. 2, Feb. 2024, pp. 304–14. Pubmed, doi:10.1002/oby.23943.
Thaker VV, Kwee LC, Chen H, Bahnson J, Ilkayeva O, Muehlbauer MJ, Wolfe B, Purnell JQ, Pi-Sunyer X, Newgard CB, Shah SH, Laferrère B, Look AHEAD Research Group. Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions. Obesity (Silver Spring). 2024 Feb;32(2):304–314.
Journal cover image

Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

February 2024

Volume

32

Issue

2

Start / End Page

304 / 314

Location

United States

Related Subject Headings

  • Weight Loss
  • Obesity, Morbid
  • Obesity
  • Humans
  • Glycated Hemoglobin
  • Gastric Bypass
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 2
  • Amino Acids, Branched-Chain