Skip to main content

Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation.

Publication ,  Journal Article
Liu, Z; Sokratian, A; Duda, AM; Xu, E; Stanhope, C; Fu, A; Strader, S; Li, H; Yuan, Y; Bobay, BG; Sipe, J; Bai, K; Lundgaard, I; Liu, N ...
Published in: Sci Adv
November 15, 2023

Recent studies have identified increasing levels of nanoplastic pollution in the environment. Here, we find that anionic nanoplastic contaminants potently precipitate the formation and propagation of α-synuclein protein fibrils through a high-affinity interaction with the amphipathic and non-amyloid component (NAC) domains in α-synuclein. Nanoplastics can internalize in neurons through clathrin-dependent endocytosis, causing a mild lysosomal impairment that slows the degradation of aggregated α-synuclein. In mice, nanoplastics combine with α-synuclein fibrils to exacerbate the spread of α-synuclein pathology across interconnected vulnerable brain regions, including the strong induction of α-synuclein inclusions in dopaminergic neurons in the substantia nigra. These results highlight a potential link for further exploration between nanoplastic pollution and α-synuclein aggregation associated with Parkinson's disease and related dementias.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Sci Adv

DOI

EISSN

2375-2548

Publication Date

November 15, 2023

Volume

9

Issue

46

Start / End Page

eadi8716

Location

United States

Related Subject Headings

  • alpha-Synuclein
  • Parkinson Disease
  • Microplastics
  • Mice
  • Inclusion Bodies
  • Dopaminergic Neurons
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, Z., Sokratian, A., Duda, A. M., Xu, E., Stanhope, C., Fu, A., … West, A. B. (2023). Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation. Sci Adv, 9(46), eadi8716. https://doi.org/10.1126/sciadv.adi8716
Liu, Zhiyong, Arpine Sokratian, Addison M. Duda, Enquan Xu, Christina Stanhope, Amber Fu, Samuel Strader, et al. “Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation.Sci Adv 9, no. 46 (November 15, 2023): eadi8716. https://doi.org/10.1126/sciadv.adi8716.
Liu Z, Sokratian A, Duda AM, Xu E, Stanhope C, Fu A, et al. Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation. Sci Adv. 2023 Nov 15;9(46):eadi8716.
Liu, Zhiyong, et al. “Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation.Sci Adv, vol. 9, no. 46, Nov. 2023, p. eadi8716. Pubmed, doi:10.1126/sciadv.adi8716.
Liu Z, Sokratian A, Duda AM, Xu E, Stanhope C, Fu A, Strader S, Li H, Yuan Y, Bobay BG, Sipe J, Bai K, Lundgaard I, Liu N, Hernandez B, Bowes Rickman C, Miller SE, West AB. Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation. Sci Adv. 2023 Nov 15;9(46):eadi8716.

Published In

Sci Adv

DOI

EISSN

2375-2548

Publication Date

November 15, 2023

Volume

9

Issue

46

Start / End Page

eadi8716

Location

United States

Related Subject Headings

  • alpha-Synuclein
  • Parkinson Disease
  • Microplastics
  • Mice
  • Inclusion Bodies
  • Dopaminergic Neurons
  • Animals