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Virtual NLST: Towards Replicating National Lung Screening Trial

Publication ,  Conference
Tushar, FI; Vancoillie, L; McCabe, C; Kavuri, A; Dahal, L; Harrawood, B; Fryling, M; Zarei, M; Sotoudeh-Paima, S; Ho, FC; Ghosh, D; Luo, S ...
Published in: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
January 1, 2024

Virtual Imaging Trials, known as VITs, provide a computational substitute for clinical trials. These traditional trials tend to be sluggish, costly, and frequently deficient in definitive evidence, all the while subjecting participants to ionizing radiation. Our VIT platform meticulously mimics essential components of the imaging process, encompassing everything from virtual patients and scanners to simulated readers. Within the scope of this intended research, we aim to authenticate our virtual imaging trial platform by duplicating the results of the National Lung Screening Trial (NLST) for lung cancer screening through the emulation of low-dose computed tomography (CT) and chest radiography (CXR) procedures. The methodology involves creating 66 unique computational phantoms, each with inserted simulated lung nodules. Replicating NLST CT imaging via Duke Legacy W20 scanner matched essential properties. Virtual imaging was done through DukeSim. A LUNA16-trained virtual reader, combining a 3D RetinaNet model (front-end) with a ResNet-10 false positive reduction model (back-end), evaluated the virtually imaged data, ensuring rigorous assessment. The back-end model achieved a sensitivity of over 95% at fewer than 3 false positives per scan for both the clinical and virtual imaged CTs. Notably, nodule diameter-based analysis showcases even higher sensitivity for nodules measuring 10 mm or more. In conclusion, the integration of diverse computational and imaging techniques, culminating in a virtual reader, demonstrates promising sensitivity. To capture both arms of the trial, future research will compare virtual reader performance on CT with CXR. This affirms the transformative potential of virtual imaging trials in advancing evidence-based medicine, offering an efficient and ethically conscious approach to medical research and development.

Duke Scholars

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

January 1, 2024

Volume

12925
 

Citation

APA
Chicago
ICMJE
MLA
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Tushar, F. I., Vancoillie, L., McCabe, C., Kavuri, A., Dahal, L., Harrawood, B., … Lo, J. Y. (2024). Virtual NLST: Towards Replicating National Lung Screening Trial. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 12925). https://doi.org/10.1117/12.3006915
Tushar, F. I., L. Vancoillie, C. McCabe, A. Kavuri, L. Dahal, B. Harrawood, M. Fryling, et al. “Virtual NLST: Towards Replicating National Lung Screening Trial.” In Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 12925, 2024. https://doi.org/10.1117/12.3006915.
Tushar FI, Vancoillie L, McCabe C, Kavuri A, Dahal L, Harrawood B, et al. Virtual NLST: Towards Replicating National Lung Screening Trial. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2024.
Tushar, F. I., et al. “Virtual NLST: Towards Replicating National Lung Screening Trial.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12925, 2024. Scopus, doi:10.1117/12.3006915.
Tushar FI, Vancoillie L, McCabe C, Kavuri A, Dahal L, Harrawood B, Fryling M, Zarei M, Sotoudeh-Paima S, Ho FC, Ghosh D, Luo S, Segars WP, Abadi E, Lafata KJ, Samei E, Lo JY. Virtual NLST: Towards Replicating National Lung Screening Trial. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2024.

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

January 1, 2024

Volume

12925