Figure 5 from Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T

<p>TLR1/2 responses associate with post–sip-T survival independent of race and TLR1/2 SNP status. <b>A–C,</b> Survival stratified by race in the merged PRIME and KCI cohorts (<b>A</b>), PRIME cohort alone (<b>B</b>), or KCI cohort alone (<b>C</b>). <b>D</b> and <b>E,</b> Survival of White (<b>D</b>) or Black (<b>E</b>) patients from the merged (PRIME and KCI) cohorts stratified by respective cohort median (PRIME or KCI) IFN-β induction after TLR1/2 stimulation. <b>F</b> and <b>G,</b> Survival of the PRIME cohort (TLR1 SNP genotyping was not performed in the KCI cohort) stratified by TLR1 602 I/I or I/S vs. TLR1 602 S/S for all races (<b>F</b>) or for White patients (<b>G</b>). <b>H</b> and <b>I,</b> Survival of patients with TLR1 602 I/I or I/S SNP (<b>H</b>) or TLR 602 S/S (<b>I</b>) stratified by median IFN-β induction after TLR1/2 stimulation. HRs and 95% CI are from the Mantel–Haenszel test; <i>P</i> values are from the Mantel–Cox log-rank test. See Supplementary Fig. S7 for extended data.</p>

Duke Scholars

Author Michael Brown Neurosurgery, Neuro-Oncology

Author Michael Dee Gunn Medicine, Cardiology

Author Smita K Nair Surgery, Surgical Sciences

Author Andrew John Armstrong Medicine, Medical Oncology