Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1.
Publication
, Journal Article
Montefiori, DC; Ferrari, G; Mielke, D; Williams, LD; Tomaras, GD
Published in: Curr HIV Res
March 27, 2025
Robust assay technologies and reference reagents are essential components in efforts to develop safe and effective antibody-mediated prevention strategies for HIV-1. Here, we de-scribe current approaches used to conduct standardized assessments of neutralizing, binding, and Fc receptor-mediated effector functions of vaccine-elicited antibodies, with an emphasis on recent developments that enable early precursors and intermediates of broadly neutralizing antibodies (bnAbs) to be monitored. We also describe how these assay technologies were adapted to facili-tate clinical evaluations of passively delivered bnAbs for HIV-1 prevention.
Duke Scholars
Published In
Curr HIV Res
DOI
EISSN
1873-4251
Publication Date
March 27, 2025
Location
Netherlands
Related Subject Headings
- Virology
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Montefiori, D. C., Ferrari, G., Mielke, D., Williams, L. D., & Tomaras, G. D. (2025). Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1. Curr HIV Res. https://doi.org/10.2174/011570162X363301250314034023
Montefiori, David C., Guido Ferrari, Dieter Mielke, LaTonya D. Williams, and Georgia D. Tomaras. “Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1.” Curr HIV Res, March 27, 2025. https://doi.org/10.2174/011570162X363301250314034023.
Montefiori DC, Ferrari G, Mielke D, Williams LD, Tomaras GD. Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1. Curr HIV Res. 2025 Mar 27;
Montefiori, David C., et al. “Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1.” Curr HIV Res, Mar. 2025. Pubmed, doi:10.2174/011570162X363301250314034023.
Montefiori DC, Ferrari G, Mielke D, Williams LD, Tomaras GD. Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1. Curr HIV Res. 2025 Mar 27;
Published In
Curr HIV Res
DOI
EISSN
1873-4251
Publication Date
March 27, 2025
Location
Netherlands
Related Subject Headings
- Virology
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences