Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1.
Journal articles
- Journal Article, Review
Montefiori, DC; Ferrari, G; Mielke, D; Williams, LD; Tomaras, GD
Published in: Curr HIV Res
2026
Robust assay technologies and reference reagents are essential components in efforts to develop safe and effective antibody-mediated prevention strategies for HIV-1. Here, we describe current approaches used to conduct standardized assessments of neutralizing, binding, and Fc receptor-mediated effector functions of vaccine-elicited antibodies, with an emphasis on recent developments that enable early precursors and intermediates of broadly neutralizing antibodies (bnAbs) to be monitored. We also describe how these assay technologies were adapted to facilitate clinical evaluations of passively delivered bnAbs for HIV-1 prevention.
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Published In
Curr HIV Res
DOI
EISSN
1873-4251
Publication Date
2026
Volume
23
Issue
6
Start / End Page
428 / 441
Location
Netherlands
Related Subject Headings
- Virology
- Humans
- HIV-1
- HIV Infections
- HIV Antibodies
- Antibodies, Neutralizing
- AIDS Vaccines
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
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Montefiori, D. C., Ferrari, G., Mielke, D., Williams, L. D., & Tomaras, G. D. (2026). Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1. Curr HIV Res, 23(6), 428–441. https://doi.org/10.2174/011570162X363301250314034023
Montefiori, David C., Guido Ferrari, Dieter Mielke, LaTonya D. Williams, and Georgia D. Tomaras. “Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1.” Curr HIV Res 23, no. 6 (2026): 428–41. https://doi.org/10.2174/011570162X363301250314034023.
Montefiori DC, Ferrari G, Mielke D, Williams LD, Tomaras GD. Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1. Curr HIV Res. 2026;23(6):428–41.
Montefiori, David C., et al. “Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1.” Curr HIV Res, vol. 23, no. 6, 2026, pp. 428–41. Pubmed, doi:10.2174/011570162X363301250314034023.
Montefiori DC, Ferrari G, Mielke D, Williams LD, Tomaras GD. Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1. Curr HIV Res. 2026;23(6):428–441.
Published In
Curr HIV Res
DOI
EISSN
1873-4251
Publication Date
2026
Volume
23
Issue
6
Start / End Page
428 / 441
Location
Netherlands
Related Subject Headings
- Virology
- Humans
- HIV-1
- HIV Infections
- HIV Antibodies
- Antibodies, Neutralizing
- AIDS Vaccines
- 42 Health sciences
- 32 Biomedical and clinical sciences