
Elucidation of the molecular mechanism of action of selective estrogen receptor modulators.
Publication
, Journal Article
McDonnell, DP; Wijayaratne, A; Chang, C-Y; Norris, JD
Published in: Am J Cardiol
July 3, 2002
The term selective estrogen receptor modulator (SERM) describes a group of pharmaceuticals that manifest estrogen receptor (ER) agonist activity in some tissues but opposes estrogen action in others. Although the name describing this class of drugs is new, the concept is not, as compounds exhibiting tissue-selective ER agonist/antagonist properties have been available for nearly 40 years. What is new is the idea that it may be possible to capitalize on the paradoxical activities of SERMs and develop them as target organ-selective ER agonists for the treatment of osteoporosis and other estrogenopathies. This realization has provided the impetus for research in this area, the progress of which is described in this review.
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Published In
Am J Cardiol
DOI
ISSN
0002-9149
Publication Date
July 3, 2002
Volume
90
Issue
1A
Start / End Page
35F / 43F
Location
United States
Related Subject Headings
- Tamoxifen
- Selective Estrogen Receptor Modulators
- Receptors, Estrogen
- Humans
- Female
- Estradiol
- Cardiovascular System & Hematology
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
McDonnell, D. P., Wijayaratne, A., Chang, C.-Y., & Norris, J. D. (2002). Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. Am J Cardiol, 90(1A), 35F-43F. https://doi.org/10.1016/s0002-9149(01)02221-4
McDonnell, Donald P., Ashini Wijayaratne, Ching-yi Chang, and John D. Norris. “Elucidation of the molecular mechanism of action of selective estrogen receptor modulators.” Am J Cardiol 90, no. 1A (July 3, 2002): 35F-43F. https://doi.org/10.1016/s0002-9149(01)02221-4.
McDonnell DP, Wijayaratne A, Chang C-Y, Norris JD. Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. Am J Cardiol. 2002 Jul 3;90(1A):35F-43F.
McDonnell, Donald P., et al. “Elucidation of the molecular mechanism of action of selective estrogen receptor modulators.” Am J Cardiol, vol. 90, no. 1A, July 2002, pp. 35F-43F. Pubmed, doi:10.1016/s0002-9149(01)02221-4.
McDonnell DP, Wijayaratne A, Chang C-Y, Norris JD. Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. Am J Cardiol. 2002 Jul 3;90(1A):35F-43F.

Published In
Am J Cardiol
DOI
ISSN
0002-9149
Publication Date
July 3, 2002
Volume
90
Issue
1A
Start / End Page
35F / 43F
Location
United States
Related Subject Headings
- Tamoxifen
- Selective Estrogen Receptor Modulators
- Receptors, Estrogen
- Humans
- Female
- Estradiol
- Cardiovascular System & Hematology
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology