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Elucidation of the molecular mechanism of action of selective estrogen receptor modulators.

Publication ,  Journal Article
McDonnell, DP; Wijayaratne, A; Chang, C-Y; Norris, JD
Published in: Am J Cardiol
July 3, 2002

The term selective estrogen receptor modulator (SERM) describes a group of pharmaceuticals that manifest estrogen receptor (ER) agonist activity in some tissues but opposes estrogen action in others. Although the name describing this class of drugs is new, the concept is not, as compounds exhibiting tissue-selective ER agonist/antagonist properties have been available for nearly 40 years. What is new is the idea that it may be possible to capitalize on the paradoxical activities of SERMs and develop them as target organ-selective ER agonists for the treatment of osteoporosis and other estrogenopathies. This realization has provided the impetus for research in this area, the progress of which is described in this review.

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Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

July 3, 2002

Volume

90

Issue

1A

Start / End Page

35F / 43F

Location

United States

Related Subject Headings

  • Tamoxifen
  • Selective Estrogen Receptor Modulators
  • Receptors, Estrogen
  • Humans
  • Female
  • Estradiol
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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McDonnell, D. P., Wijayaratne, A., Chang, C.-Y., & Norris, J. D. (2002). Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. Am J Cardiol, 90(1A), 35F-43F. https://doi.org/10.1016/s0002-9149(01)02221-4
McDonnell, Donald P., Ashini Wijayaratne, Ching-yi Chang, and John D. Norris. “Elucidation of the molecular mechanism of action of selective estrogen receptor modulators.Am J Cardiol 90, no. 1A (July 3, 2002): 35F-43F. https://doi.org/10.1016/s0002-9149(01)02221-4.
McDonnell DP, Wijayaratne A, Chang C-Y, Norris JD. Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. Am J Cardiol. 2002 Jul 3;90(1A):35F-43F.
McDonnell, Donald P., et al. “Elucidation of the molecular mechanism of action of selective estrogen receptor modulators.Am J Cardiol, vol. 90, no. 1A, July 2002, pp. 35F-43F. Pubmed, doi:10.1016/s0002-9149(01)02221-4.
McDonnell DP, Wijayaratne A, Chang C-Y, Norris JD. Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. Am J Cardiol. 2002 Jul 3;90(1A):35F-43F.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

July 3, 2002

Volume

90

Issue

1A

Start / End Page

35F / 43F

Location

United States

Related Subject Headings

  • Tamoxifen
  • Selective Estrogen Receptor Modulators
  • Receptors, Estrogen
  • Humans
  • Female
  • Estradiol
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology