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Minimum energy single-shock internal atrial defibrillation in sheep.

Publication ,  Journal Article
Goodman, AM; Clyde, MA; Burdick, DS; Idriss, SF; Wolf, PD
Published in: J Interv Card Electrophysiol
April 2004

Well-tolerated internal atrial defibrillation shocks must be below the pain threshold, which has been estimated to be less than 1 Joule. Defibrillation of the atria with low energy is made possible by delivering shocks at the low end of the defibrillation dose-response curve. We studied low-energy defibrillation in sheep to test the hypothesis that the energy that defibrillates the atria 10% of the time (ED10) is less than 1 Joule. The ED10 was estimated in seven sheep with rapid pacing induced chronic atrial fibrillation (AF). Low-energy defibrillation shocks were delivered from coronary sinus (CS) to superior vena cava (SVC) and the ED10 and ED50 (energy that defibrillates the atria 50% of the time) were then calculated using logistic regression. The mean ratio of ED10 to ED50 was 0.50, indicating that on average, the ED10 was equal to half of the ED50. ED10 shocks had energies ranging from 1.2 to 5.8 Joules. These results suggest that painless single-shock low-energy defibrillation may not be feasible.

Duke Scholars

Published In

J Interv Card Electrophysiol

DOI

ISSN

1383-875X

Publication Date

April 2004

Volume

10

Issue

2

Start / End Page

131 / 138

Location

Netherlands

Related Subject Headings

  • Sheep, Domestic
  • Sensitivity and Specificity
  • Male
  • Logistic Models
  • Female
  • Electric Countershock
  • Disease Models, Animal
  • Differential Threshold
  • Cardiovascular System & Hematology
  • Atrial Function
 

Citation

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Goodman, A. M., Clyde, M. A., Burdick, D. S., Idriss, S. F., & Wolf, P. D. (2004). Minimum energy single-shock internal atrial defibrillation in sheep. J Interv Card Electrophysiol, 10(2), 131–138. https://doi.org/10.1023/B:JICE.0000019266.09648.f6
Goodman, Amy M., Merlise A. Clyde, Donald S. Burdick, Salim F. Idriss, and Patrick D. Wolf. “Minimum energy single-shock internal atrial defibrillation in sheep.J Interv Card Electrophysiol 10, no. 2 (April 2004): 131–38. https://doi.org/10.1023/B:JICE.0000019266.09648.f6.
Goodman AM, Clyde MA, Burdick DS, Idriss SF, Wolf PD. Minimum energy single-shock internal atrial defibrillation in sheep. J Interv Card Electrophysiol. 2004 Apr;10(2):131–8.
Goodman, Amy M., et al. “Minimum energy single-shock internal atrial defibrillation in sheep.J Interv Card Electrophysiol, vol. 10, no. 2, Apr. 2004, pp. 131–38. Pubmed, doi:10.1023/B:JICE.0000019266.09648.f6.
Goodman AM, Clyde MA, Burdick DS, Idriss SF, Wolf PD. Minimum energy single-shock internal atrial defibrillation in sheep. J Interv Card Electrophysiol. 2004 Apr;10(2):131–138.
Journal cover image

Published In

J Interv Card Electrophysiol

DOI

ISSN

1383-875X

Publication Date

April 2004

Volume

10

Issue

2

Start / End Page

131 / 138

Location

Netherlands

Related Subject Headings

  • Sheep, Domestic
  • Sensitivity and Specificity
  • Male
  • Logistic Models
  • Female
  • Electric Countershock
  • Disease Models, Animal
  • Differential Threshold
  • Cardiovascular System & Hematology
  • Atrial Function