Clinical trial issues in weight-loss therapy.
Publication
, Journal Article
Patel, MR; Donahue, M; Wilson, PWF; Califf, RM
Published in: Am Heart J
March 2006
BACKGROUND: Overweight and obesity rates continue to increase nationally, generating significant interest in weight-loss therapies to address both the burden of obesity-associated chronic disease and individual concerns about appearance. Effective obesity therapies also have the potential for off-label use and unintended consequences. METHODS: The behavioral, pharmacologic, and surgical therapies for obesity are reviewed. Clinical trial issues common to chronic disease states and issues specific to obesity trials are examined. Finally, study designs for obesity therapy, including populations, control arms, sample size, and duration of therapy, are discussed.
Duke Scholars
Published In
Am Heart J
DOI
EISSN
1097-6744
Publication Date
March 2006
Volume
151
Issue
3
Start / End Page
633 / 642
Location
United States
Related Subject Headings
- Prognosis
- Obesity
- Life Style
- Humans
- Diabetes Mellitus
- Cyclobutanes
- Comorbidity
- Clinical Trials as Topic
- Cardiovascular System & Hematology
- Cardiovascular Diseases
Citation
APA
Chicago
ICMJE
MLA
NLM
Patel, M. R., Donahue, M., Wilson, P. W. F., & Califf, R. M. (2006). Clinical trial issues in weight-loss therapy. Am Heart J, 151(3), 633–642. https://doi.org/10.1016/j.ahj.2005.03.006
Patel, Manesh R., Mark Donahue, Peter W. F. Wilson, and Robert M. Califf. “Clinical trial issues in weight-loss therapy.” Am Heart J 151, no. 3 (March 2006): 633–42. https://doi.org/10.1016/j.ahj.2005.03.006.
Patel MR, Donahue M, Wilson PWF, Califf RM. Clinical trial issues in weight-loss therapy. Am Heart J. 2006 Mar;151(3):633–42.
Patel, Manesh R., et al. “Clinical trial issues in weight-loss therapy.” Am Heart J, vol. 151, no. 3, Mar. 2006, pp. 633–42. Pubmed, doi:10.1016/j.ahj.2005.03.006.
Patel MR, Donahue M, Wilson PWF, Califf RM. Clinical trial issues in weight-loss therapy. Am Heart J. 2006 Mar;151(3):633–642.
Published In
Am Heart J
DOI
EISSN
1097-6744
Publication Date
March 2006
Volume
151
Issue
3
Start / End Page
633 / 642
Location
United States
Related Subject Headings
- Prognosis
- Obesity
- Life Style
- Humans
- Diabetes Mellitus
- Cyclobutanes
- Comorbidity
- Clinical Trials as Topic
- Cardiovascular System & Hematology
- Cardiovascular Diseases