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Mast cell activators: a new class of highly effective vaccine adjuvants.

Publication ,  Journal Article
McLachlan, JB; Shelburne, CP; Hart, JP; Pizzo, SV; Goyal, R; Brooking-Dixon, R; Staats, HF; Abraham, SN
Published in: Nat Med
May 2008

Mast cells (MCs) have recently received recognition as prominent effectors in the regulation of immune cell migration to draining lymph nodes and lymphocyte activation. However, their role in the development of humoral immune responses is not clear. Here, we demonstrate that subcutaneous or nasal administration of small-molecule MC activators with vaccine antigens evokes large increases in antigen-specific serum immunoglobulin G (IgG) responses. These responses were MC dependent and correlated with increased dendritic cell and lymphocyte recruitment to draining lymph nodes. Nasal instillation of these formulations also evoked antigen-specific secretory IgA and provided protection against anthrax lethal toxin challenge in vitro and against vaccinia virus infection in vivo. Collectively, these results define the MC as an integral sensory arm of the adaptive immune system. Moreover, they highlight MC activators as a new class of vaccine adjuvants, capable of inducing protective antigen-specific immune responses through needle-free routes of administration.

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Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

May 2008

Volume

14

Issue

5

Start / End Page

536 / 541

Location

United States

Related Subject Headings

  • p-Methoxy-N-methylphenethylamine
  • Vaccinia
  • Peptides
  • Peptide Fragments
  • Mice, Mutant Strains
  • Mice
  • Mast Cells
  • Lymphoid Tissue
  • Immunology
  • Immunoglobulin G
 

Citation

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Chicago
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McLachlan, J. B., Shelburne, C. P., Hart, J. P., Pizzo, S. V., Goyal, R., Brooking-Dixon, R., … Abraham, S. N. (2008). Mast cell activators: a new class of highly effective vaccine adjuvants. Nat Med, 14(5), 536–541. https://doi.org/10.1038/nm1757
McLachlan, James B., Christopher P. Shelburne, Justin P. Hart, Salvatore V. Pizzo, Rajen Goyal, Rhea Brooking-Dixon, Herman F. Staats, and Soman N. Abraham. “Mast cell activators: a new class of highly effective vaccine adjuvants.Nat Med 14, no. 5 (May 2008): 536–41. https://doi.org/10.1038/nm1757.
McLachlan JB, Shelburne CP, Hart JP, Pizzo SV, Goyal R, Brooking-Dixon R, et al. Mast cell activators: a new class of highly effective vaccine adjuvants. Nat Med. 2008 May;14(5):536–41.
McLachlan, James B., et al. “Mast cell activators: a new class of highly effective vaccine adjuvants.Nat Med, vol. 14, no. 5, May 2008, pp. 536–41. Pubmed, doi:10.1038/nm1757.
McLachlan JB, Shelburne CP, Hart JP, Pizzo SV, Goyal R, Brooking-Dixon R, Staats HF, Abraham SN. Mast cell activators: a new class of highly effective vaccine adjuvants. Nat Med. 2008 May;14(5):536–541.

Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

May 2008

Volume

14

Issue

5

Start / End Page

536 / 541

Location

United States

Related Subject Headings

  • p-Methoxy-N-methylphenethylamine
  • Vaccinia
  • Peptides
  • Peptide Fragments
  • Mice, Mutant Strains
  • Mice
  • Mast Cells
  • Lymphoid Tissue
  • Immunology
  • Immunoglobulin G