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Dual-mode intracranial catheter integrating 3D ultrasound imaging and hyperthermia for neuro-oncology: feasibility study.

Publication ,  Journal Article
Herickhoff, CD; Light, ED; Bing, KF; Mukundan, S; Grant, GA; Wolf, PD; Smith, SW
Published in: Ultrason Imaging
April 2009

In this study, we investigated the feasibility of an intracranial catheter transducer with dual-mode capability of real-time 3D (RT3D) imaging and ultrasound hyperthermia, for application in the visualization and treatment of tumors in the brain. Feasibility is demonstrated in two ways: first by using a 50-element linear array transducer (17 mm x 3.1 mm aperture) operating at 4.4 MHz with our Volumetrics diagnostic scanner and custom, electrical impedance-matching circuits to achieve a temperature rise over 4 degrees C in excised pork muscle, and second, by designing and constructing a 12 Fr, integrated matrix and linear-array catheter transducer prototype for combined RT3D imaging and heating capability. This dual-mode catheter incorporated 153 matrix array elements and 11 linear array elements diced on a 0.2 mm pitch, with a total aperture size of 8.4 mm x 2.3 mm. This 3.64 MHz array achieved a 3.5 degrees C in vitro temperature rise at a 2 cm focal distance in tissue-mimicking material. The dual-mode catheter prototype was compared with a Siemens 10 Fr AcuNav catheter as a gold standard in experiments assessing image quality and therapeutic potential and both probes were used in an in vivo canine brain model to image anatomical structures and color Doppler blood flow and to attempt in vivo heating.

Duke Scholars

Published In

Ultrason Imaging

DOI

ISSN

0161-7346

Publication Date

April 2009

Volume

31

Issue

2

Start / End Page

81 / 100

Location

England

Related Subject Headings

  • Ultrasonography, Interventional
  • Ultrasonography, Doppler, Color
  • Transducers
  • Swine
  • Phantoms, Imaging
  • Imaging, Three-Dimensional
  • Hyperthermia, Induced
  • Feasibility Studies
  • Equipment Design
  • Dogs
 

Citation

APA
Chicago
ICMJE
MLA
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Herickhoff, C. D., Light, E. D., Bing, K. F., Mukundan, S., Grant, G. A., Wolf, P. D., & Smith, S. W. (2009). Dual-mode intracranial catheter integrating 3D ultrasound imaging and hyperthermia for neuro-oncology: feasibility study. Ultrason Imaging, 31(2), 81–100. https://doi.org/10.1177/016173460903100201
Herickhoff, Carl D., Edward D. Light, Kristin F. Bing, Srinivasan Mukundan, Gerald A. Grant, Patrick D. Wolf, and Stephen W. Smith. “Dual-mode intracranial catheter integrating 3D ultrasound imaging and hyperthermia for neuro-oncology: feasibility study.Ultrason Imaging 31, no. 2 (April 2009): 81–100. https://doi.org/10.1177/016173460903100201.
Herickhoff CD, Light ED, Bing KF, Mukundan S, Grant GA, Wolf PD, et al. Dual-mode intracranial catheter integrating 3D ultrasound imaging and hyperthermia for neuro-oncology: feasibility study. Ultrason Imaging. 2009 Apr;31(2):81–100.
Herickhoff, Carl D., et al. “Dual-mode intracranial catheter integrating 3D ultrasound imaging and hyperthermia for neuro-oncology: feasibility study.Ultrason Imaging, vol. 31, no. 2, Apr. 2009, pp. 81–100. Pubmed, doi:10.1177/016173460903100201.
Herickhoff CD, Light ED, Bing KF, Mukundan S, Grant GA, Wolf PD, Smith SW. Dual-mode intracranial catheter integrating 3D ultrasound imaging and hyperthermia for neuro-oncology: feasibility study. Ultrason Imaging. 2009 Apr;31(2):81–100.
Journal cover image

Published In

Ultrason Imaging

DOI

ISSN

0161-7346

Publication Date

April 2009

Volume

31

Issue

2

Start / End Page

81 / 100

Location

England

Related Subject Headings

  • Ultrasonography, Interventional
  • Ultrasonography, Doppler, Color
  • Transducers
  • Swine
  • Phantoms, Imaging
  • Imaging, Three-Dimensional
  • Hyperthermia, Induced
  • Feasibility Studies
  • Equipment Design
  • Dogs