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Age at onset in two common neurodegenerative diseases is genetically controlled.

Publication ,  Journal Article
Li, Y-J; Scott, WK; Hedges, DJ; Zhang, F; Gaskell, PC; Nance, MA; Watts, RL; Hubble, JP; Koller, WC; Pahwa, R; Stern, MB; Hiner, BC; Reed, AD ...
Published in: Am J Hum Genet
April 2002
Published version (DOI) Link to item

To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%--60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D10S1239 and D10S1237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.

Duke Scholars

Yi-Ju Li
Author Yi-Ju Li Biostatistics & Bioinformatics, Division of Integrative Geno ...
Burton Lasater Scott
Author Burton Lasater Scott Neurology, Movement Disorders
Kathleen Anne Welsh-Bohmer
Author Kathleen Anne Welsh-Bohmer Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
Margaret Ann Pericak-Vance
Author Margaret Ann Pericak-Vance Medicine, Hematology
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Published In

Am J Hum Genet

DOI

10.1086/339815

ISSN

0002-9297

Publication Date

April 2002

Volume

70

Issue

4

Start / End Page

985 / 993

Location

United States

Related Subject Headings

  • Parkinson Disease
  • Multifactorial Inheritance
  • Models, Genetic
  • Middle Aged
  • Lod Score
  • Humans
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Chromosomes, Human, Pair 6
  • Chromosomes, Human, Pair 10
 

Citation

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Chicago
ICMJE
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Li, Y.-J., Scott, W. K., Hedges, D. J., Zhang, F., Gaskell, P. C., Nance, M. A., … Pericak-Vance, M. A. (2002). Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet, 70(4), 985–993. https://doi.org/10.1086/339815
Li, Yi-Ju, William K. Scott, Dale J. Hedges, Fengyu Zhang, P Craig Gaskell, Martha A. Nance, Ray L. Watts, et al. “Age at onset in two common neurodegenerative diseases is genetically controlled.” Am J Hum Genet 70, no. 4 (April 2002): 985–93. https://doi.org/10.1086/339815.
Li Y-J, Scott WK, Hedges DJ, Zhang F, Gaskell PC, Nance MA, et al. Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet. 2002 Apr;70(4):985–93.
Li, Yi-Ju, et al. “Age at onset in two common neurodegenerative diseases is genetically controlled.” Am J Hum Genet, vol. 70, no. 4, Apr. 2002, pp. 985–93. Pubmed, doi:10.1086/339815.
Li Y-J, Scott WK, Hedges DJ, Zhang F, Gaskell PC, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Allen FA, Goetz CG, Mastaglia F, Stajich JM, Gibson RA, Middleton LT, Saunders AM, Scott BL, Small GW, Nicodemus KK, Reed AD, Schmechel DE, Welsh-Bohmer KA, Conneally PM, Roses AD, Gilbert JR, Vance JM, Haines JL, Pericak-Vance MA. Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet. 2002 Apr;70(4):985–993.
Journal cover image

Published In

Am J Hum Genet

DOI

10.1086/339815

ISSN

0002-9297

Publication Date

April 2002

Volume

70

Issue

4

Start / End Page

985 / 993

Location

United States

Related Subject Headings

  • Parkinson Disease
  • Multifactorial Inheritance
  • Models, Genetic
  • Middle Aged
  • Lod Score
  • Humans
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Chromosomes, Human, Pair 6
  • Chromosomes, Human, Pair 10