Clinical trial design in neonatal pharmacology: effect of center differences, with lessons from the Pediatric Oncology Cooperative Research experience.
Publication
, Journal Article
Moran, C; Smith, PB; Cohen-Wolkowiez, M; Benjamin, DK
Published in: Clin Pharmacol Ther
December 2009
Survival for premature neonates has improved dramatically over the past 20 years; however, there has been minimal improvement in prematurity-associated morbidities. Morbidity rates and assessment of outcomes vary across neonatology intensive care units (NICUs). Here, we address the reasons underlying these differences, note the impact that this center variation has on trial design and interpretation, and highlight the success of the efforts in pediatric oncology to develop standards of care through the conduct of multicenter clinical trials.
Duke Scholars
Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
December 2009
Volume
86
Issue
6
Start / End Page
589 / 591
Location
United States
Related Subject Headings
- United States
- Treatment Outcome
- Research Design
- Quality of Health Care
- Practice Guidelines as Topic
- Pharmacology & Pharmacy
- Multicenter Studies as Topic
- Intensive Care Units, Neonatal
- Infant, Premature, Diseases
- Infant, Premature
Citation
APA
Chicago
ICMJE
MLA
NLM
Moran, C., Smith, P. B., Cohen-Wolkowiez, M., & Benjamin, D. K. (2009). Clinical trial design in neonatal pharmacology: effect of center differences, with lessons from the Pediatric Oncology Cooperative Research experience. Clin Pharmacol Ther, 86(6), 589–591. https://doi.org/10.1038/clpt.2009.175
Moran, C., P. B. Smith, M. Cohen-Wolkowiez, and D. K. Benjamin. “Clinical trial design in neonatal pharmacology: effect of center differences, with lessons from the Pediatric Oncology Cooperative Research experience.” Clin Pharmacol Ther 86, no. 6 (December 2009): 589–91. https://doi.org/10.1038/clpt.2009.175.
Moran C, Smith PB, Cohen-Wolkowiez M, Benjamin DK. Clinical trial design in neonatal pharmacology: effect of center differences, with lessons from the Pediatric Oncology Cooperative Research experience. Clin Pharmacol Ther. 2009 Dec;86(6):589–91.
Moran, C., et al. “Clinical trial design in neonatal pharmacology: effect of center differences, with lessons from the Pediatric Oncology Cooperative Research experience.” Clin Pharmacol Ther, vol. 86, no. 6, Dec. 2009, pp. 589–91. Pubmed, doi:10.1038/clpt.2009.175.
Moran C, Smith PB, Cohen-Wolkowiez M, Benjamin DK. Clinical trial design in neonatal pharmacology: effect of center differences, with lessons from the Pediatric Oncology Cooperative Research experience. Clin Pharmacol Ther. 2009 Dec;86(6):589–591.
Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
December 2009
Volume
86
Issue
6
Start / End Page
589 / 591
Location
United States
Related Subject Headings
- United States
- Treatment Outcome
- Research Design
- Quality of Health Care
- Practice Guidelines as Topic
- Pharmacology & Pharmacy
- Multicenter Studies as Topic
- Intensive Care Units, Neonatal
- Infant, Premature, Diseases
- Infant, Premature