Monitoring cellular immune responses to cancer immunotherapy.
Publication
, Journal Article
Morse, MA; Clay, TM; Hobeika, AC; Mosca, PJ; Lyerly, HK
Published in: Curr Opin Mol Ther
February 2001
Many clinical trials are testing the feasibility of stimulating the immune system to treat cancer. Although the efficacy of this approach will ultimately be determined by clinically relevant endpoints, detection of the magnitude and activity of the immune response is an important intermediate point in the development of these strategies. Assays that predict clinically relevant endpoints are particularly desirable for helping to determine which strategies should ultimately be tested in larger randomized clinical trials. In this review, we will discuss these cellular immunological assays and the current status of their role in clinical trials of immunotherapy.
Duke Scholars
Published In
Curr Opin Mol Ther
ISSN
1464-8431
Publication Date
February 2001
Volume
3
Issue
1
Start / End Page
45 / 52
Location
England
Related Subject Headings
- T-Lymphocytes
- Receptors, Antigen, T-Cell, alpha-beta
- Peptides
- Neoplasms
- Lymphocyte Activation
- In Vitro Techniques
- Immunotherapy
- Immunoassay
- Immunity, Cellular
- Hypersensitivity, Delayed
Citation
APA
Chicago
ICMJE
MLA
NLM
Morse, M. A., Clay, T. M., Hobeika, A. C., Mosca, P. J., & Lyerly, H. K. (2001). Monitoring cellular immune responses to cancer immunotherapy. Curr Opin Mol Ther, 3(1), 45–52.
Morse, M. A., T. M. Clay, A. C. Hobeika, P. J. Mosca, and H. K. Lyerly. “Monitoring cellular immune responses to cancer immunotherapy.” Curr Opin Mol Ther 3, no. 1 (February 2001): 45–52.
Morse MA, Clay TM, Hobeika AC, Mosca PJ, Lyerly HK. Monitoring cellular immune responses to cancer immunotherapy. Curr Opin Mol Ther. 2001 Feb;3(1):45–52.
Morse, M. A., et al. “Monitoring cellular immune responses to cancer immunotherapy.” Curr Opin Mol Ther, vol. 3, no. 1, Feb. 2001, pp. 45–52.
Morse MA, Clay TM, Hobeika AC, Mosca PJ, Lyerly HK. Monitoring cellular immune responses to cancer immunotherapy. Curr Opin Mol Ther. 2001 Feb;3(1):45–52.
Published In
Curr Opin Mol Ther
ISSN
1464-8431
Publication Date
February 2001
Volume
3
Issue
1
Start / End Page
45 / 52
Location
England
Related Subject Headings
- T-Lymphocytes
- Receptors, Antigen, T-Cell, alpha-beta
- Peptides
- Neoplasms
- Lymphocyte Activation
- In Vitro Techniques
- Immunotherapy
- Immunoassay
- Immunity, Cellular
- Hypersensitivity, Delayed