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Blood gene expression signatures predict invasive candidiasis.

Publication ,  Journal Article
Zaas, AK; Aziz, H; Lucas, J; Perfect, JR; Ginsburg, GS
Published in: Sci Transl Med
March 3, 2010

Candidemia is the fourth most common bloodstream infection, with Candida albicans being the most common causative species. Success in reducing the associated morbidity and mortality has been limited by the inadequacy and time delay of currently available diagnostic modalities. Focusing on host response to infection, we used a murine model to develop a blood gene expression signature that accurately classified mice with candidemia and distinguished candidemia from Staphylococcus aureus bacteremia. Validation of the signature was achieved in an independent cohort of mice. Genes represented in the signature have known associations with host defense against Candida and other microorganisms. Our results demonstrate a temporal pattern of host molecular responses that distinguish candidemia from S. aureus-induced bacteremia and establish a novel paradigm for infectious disease diagnosis.

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Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

March 3, 2010

Volume

2

Issue

21

Start / End Page

21ra17

Location

United States

Related Subject Headings

  • Time Factors
  • Species Specificity
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Gene Expression Profiling
  • Disease Progression
  • Candidiasis
  • Candida albicans
  • Bacteremia
 

Citation

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Zaas, A. K., Aziz, H., Lucas, J., Perfect, J. R., & Ginsburg, G. S. (2010). Blood gene expression signatures predict invasive candidiasis. Sci Transl Med, 2(21), 21ra17. https://doi.org/10.1126/scitranslmed.3000715
Zaas, Aimee K., Hamza Aziz, Joseph Lucas, John R. Perfect, and Geoffrey S. Ginsburg. “Blood gene expression signatures predict invasive candidiasis.Sci Transl Med 2, no. 21 (March 3, 2010): 21ra17. https://doi.org/10.1126/scitranslmed.3000715.
Zaas AK, Aziz H, Lucas J, Perfect JR, Ginsburg GS. Blood gene expression signatures predict invasive candidiasis. Sci Transl Med. 2010 Mar 3;2(21):21ra17.
Zaas, Aimee K., et al. “Blood gene expression signatures predict invasive candidiasis.Sci Transl Med, vol. 2, no. 21, Mar. 2010, p. 21ra17. Pubmed, doi:10.1126/scitranslmed.3000715.
Zaas AK, Aziz H, Lucas J, Perfect JR, Ginsburg GS. Blood gene expression signatures predict invasive candidiasis. Sci Transl Med. 2010 Mar 3;2(21):21ra17.

Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

March 3, 2010

Volume

2

Issue

21

Start / End Page

21ra17

Location

United States

Related Subject Headings

  • Time Factors
  • Species Specificity
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Gene Expression Profiling
  • Disease Progression
  • Candidiasis
  • Candida albicans
  • Bacteremia