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Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection.

Publication ,  Journal Article
Hudson, LL; Louise Markert, M; Devlin, BH; Haynes, BF; Sempowski, GD
Published in: Semin Immunol
October 2007

The thymus is essential for proper development and maintenance of a broad T cell repertoire capable of recognizing a wide-range of foreign antigens. Recent advances in multicolor flow cytometry, non-invasive imaging techniques, and molecular assessments of thymic function have enabled a more comprehensive characterization of human thymic output in clinical settings than in the past. These techniques have been particularly valuable in monitoring human T cells after therapeutic thymic grafting for complete DiGeorge syndrome and during HIV-1 infection and AIDS. By defining the degree and mechanisms of T cell reconstitution in these settings, clinical investigators and primary caregivers have been able to better diagnose, treat and care for individuals with congenital or acquired immune deficiencies associated with loss of thymic function.

Duke Scholars

Published In

Semin Immunol

DOI

ISSN

1044-5323

Publication Date

October 2007

Volume

19

Issue

5

Start / End Page

297 / 309

Location

England

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Interleukin-2
  • Immunology
  • Humans
  • HIV-1
  • DiGeorge Syndrome
  • CD4 Lymphocyte Count
  • Acquired Immunodeficiency Syndrome
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hudson, L. L., Louise Markert, M., Devlin, B. H., Haynes, B. F., & Sempowski, G. D. (2007). Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection. Semin Immunol, 19(5), 297–309. https://doi.org/10.1016/j.smim.2007.10.002
Hudson, Lori L., M. Louise Markert, Blythe H. Devlin, Barton F. Haynes, and Gregory D. Sempowski. “Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection.Semin Immunol 19, no. 5 (October 2007): 297–309. https://doi.org/10.1016/j.smim.2007.10.002.
Hudson LL, Louise Markert M, Devlin BH, Haynes BF, Sempowski GD. Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection. Semin Immunol. 2007 Oct;19(5):297–309.
Hudson, Lori L., et al. “Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection.Semin Immunol, vol. 19, no. 5, Oct. 2007, pp. 297–309. Pubmed, doi:10.1016/j.smim.2007.10.002.
Hudson LL, Louise Markert M, Devlin BH, Haynes BF, Sempowski GD. Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection. Semin Immunol. 2007 Oct;19(5):297–309.
Journal cover image

Published In

Semin Immunol

DOI

ISSN

1044-5323

Publication Date

October 2007

Volume

19

Issue

5

Start / End Page

297 / 309

Location

England

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Interleukin-2
  • Immunology
  • Humans
  • HIV-1
  • DiGeorge Syndrome
  • CD4 Lymphocyte Count
  • Acquired Immunodeficiency Syndrome