Scholars@Duke
Journal cover image

B cell responses to HIV-1 infection and vaccination: pathways to preventing infection.

Publication ,  Journal Article
Haynes, BF; Moody, MA; Liao, H-X; Verkoczy, L; Tomaras, GD
Published in: Trends Mol Med
February 2011
Published version (DOI) Link to item

The B cell arm of the immune response becomes activated soon after HIV-1 transmission, yet the initial antibody response does not control HIV-1 replication, and it takes months for neutralizing antibodies to develop against the autologous virus. Antibodies that can be broadly protective are made only in a minority of subjects and take years to develop--too late to affect the course of disease. New studies of the earliest stages of HIV-1 infection, new techniques to probe the human B cell repertoire, the modest degree of efficacy in a vaccine trial and new studies of human monoclonal antibodies that represent the types of immune responses an HIV-1 vaccine should induce are collectively illuminating paths that a successful HIV-1 vaccine might take.

Duke Scholars

Michael Anthony Moody
Author Michael Anthony Moody Pediatrics, Infectious Diseases
Barton Ford Haynes
Author Barton Ford Haynes Medicine, Duke Human Vaccine Institute
Georgia Doris Tomaras
Author Georgia Doris Tomaras Surgery, Surgical Sciences

Published In

Trends Mol Med

DOI

10.1016/j.molmed.2010.10.008

EISSN

1471-499X

Publication Date

February 2011

Volume

17

Issue

2

Start / End Page

108 / 116

Location

England

Related Subject Headings

  • Vaccination
  • Mucous Membrane
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • B-Lymphocytes
  • Antibody Formation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Haynes, B. F., Moody, M. A., Liao, H.-X., Verkoczy, L., & Tomaras, G. D. (2011). B cell responses to HIV-1 infection and vaccination: pathways to preventing infection. Trends Mol Med, 17(2), 108–116. https://doi.org/10.1016/j.molmed.2010.10.008
Haynes, Barton F., M Anthony Moody, Hua-Xin Liao, Laurent Verkoczy, and Georgia D. Tomaras. “B cell responses to HIV-1 infection and vaccination: pathways to preventing infection.” Trends Mol Med 17, no. 2 (February 2011): 108–16. https://doi.org/10.1016/j.molmed.2010.10.008.
Haynes BF, Moody MA, Liao H-X, Verkoczy L, Tomaras GD. B cell responses to HIV-1 infection and vaccination: pathways to preventing infection. Trends Mol Med. 2011 Feb;17(2):108–16.
Haynes, Barton F., et al. “B cell responses to HIV-1 infection and vaccination: pathways to preventing infection.” Trends Mol Med, vol. 17, no. 2, Feb. 2011, pp. 108–16. Pubmed, doi:10.1016/j.molmed.2010.10.008.
Haynes BF, Moody MA, Liao H-X, Verkoczy L, Tomaras GD. B cell responses to HIV-1 infection and vaccination: pathways to preventing infection. Trends Mol Med. 2011 Feb;17(2):108–116.
Journal cover image

Published In

Trends Mol Med

DOI

10.1016/j.molmed.2010.10.008

EISSN

1471-499X

Publication Date

February 2011

Volume

17

Issue

2

Start / End Page

108 / 116

Location

England

Related Subject Headings

  • Vaccination
  • Mucous Membrane
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • B-Lymphocytes
  • Antibody Formation