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The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection.

Publication ,  Journal Article
Haynes, BF; Markert, ML; Sempowski, GD; Patel, DD; Hale, LP
Published in: Annu Rev Immunol
2000

The human thymus is a complex chimeric organ comprised of central (thymic epithelial space) and peripheral (perivascular space) components that functions well into adult life to produce naive T lymphocytes. Recent advances in identifying thymic emigrants and development of safe methods to study thymic function in vivo in adults have provided new opportunities to understand the role that the human thymus plays in immune reconstitution in aging, in bone marrow transplantation, and in HIV-1 infection. The emerging concept is that there are age-dependent contributions of thymic emigrants and proliferation of postthymic T cells to maintain the peripheral T cell pool and to contribute to T cell regeneration, with the thymus contributing more at younger ages and peripheral T cell expansion contributing more in older subjects. New studies have revealed a dynamic interplay between postnatal thymus output and peripheral T cell pool proliferation, which play important roles in determining the nature of immune reconstitution in congenital immunodeficiency diseases, in bone marrow transplantation, and in HIV-1 infection. In this paper, we review recent data on human postnatal thymus function that, taken together, support the notion that the human thymus is functional well into the sixth decade and plays a role throughout life to optimize human immune system function.

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Published In

Annu Rev Immunol

DOI

ISSN

0732-0582

Publication Date

2000

Volume

18

Start / End Page

529 / 560

Location

United States

Related Subject Headings

  • Transplantation Immunology
  • Thymus Gland
  • T-Lymphocytes
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • DiGeorge Syndrome
  • Bone Marrow Transplantation
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Haynes, B. F., Markert, M. L., Sempowski, G. D., Patel, D. D., & Hale, L. P. (2000). The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol, 18, 529–560. https://doi.org/10.1146/annurev.immunol.18.1.529
Haynes, B. F., M. L. Markert, G. D. Sempowski, D. D. Patel, and L. P. Hale. “The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection.Annu Rev Immunol 18 (2000): 529–60. https://doi.org/10.1146/annurev.immunol.18.1.529.
Haynes BF, Markert ML, Sempowski GD, Patel DD, Hale LP. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol. 2000;18:529–60.
Haynes, B. F., et al. “The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection.Annu Rev Immunol, vol. 18, 2000, pp. 529–60. Pubmed, doi:10.1146/annurev.immunol.18.1.529.
Haynes BF, Markert ML, Sempowski GD, Patel DD, Hale LP. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol. 2000;18:529–560.

Published In

Annu Rev Immunol

DOI

ISSN

0732-0582

Publication Date

2000

Volume

18

Start / End Page

529 / 560

Location

United States

Related Subject Headings

  • Transplantation Immunology
  • Thymus Gland
  • T-Lymphocytes
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • DiGeorge Syndrome
  • Bone Marrow Transplantation
  • Animals