Scholars@Duke publication: A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses.

A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses.

Publication , Journal Article

Liao, H-X; Sutherland, LL; Xia, S-M; Brock, ME; Scearce, RM; Vanleeuwen, S; Alam, SM; McAdams, M; Weaver, EA; Camacho, Z; Ma, B-J; Li, Y ...

Published in: Virology

September 30, 2006

Published version (DOI) Link to item

HIV-1 subtype C is the most common HIV-1 group M subtype in Africa and many parts of Asia. However, to date HIV-1 vaccine candidate immunogens have not induced potent and broadly neutralizing antibodies against subtype C primary isolates. We have used a centralized gene strategy to address HIV-1 diversity and generated a group M consensus envelope gene with shortened consensus variable loops (CON-S) for comparative studies with wild-type (WT) Env immunogens. Our results indicate that the consensus HIV-1 group M CON-S Env elicited cross-subtype neutralizing antibodies of similar or greater breadth and titer than the WT Envs tested, indicating the utility of a centralized gene strategy. Our study also shows the feasibility of iterative improvements in Env immunogenicity by rational design of centralized genes.

Duke Scholars

Author David Charles Montefiori Surgery, Surgical Sciences

Author S. Munir Alam Medicine, Duke Human Vaccine Institute

Author Feng Gao Medicine, Infectious Diseases

Author Barton Ford Haynes Medicine, Duke Human Vaccine Institute

Published In

Virology

DOI

10.1016/j.virol.2006.04.043

ISSN

0042-6822

Publication Date

September 30, 2006

Volume

353

Issue

Start / End Page

268 / 282

Location

United States

Related Subject Headings

env Gene Products, Human Immunodeficiency Virus
Virology
Neutralization Tests
Molecular Sequence Data
Immunophenotyping
HIV-1
HIV Infections
HIV Antibodies
Guinea Pigs
Gene Products, env

Citation

APA

Chicago

ICMJE

MLA

NLM

Liao, H.-X., Sutherland, L. L., Xia, S.-M., Brock, M. E., Scearce, R. M., Vanleeuwen, S., … Haynes, B. F. (2006). A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses. Virology, 353(2), 268–282. https://doi.org/10.1016/j.virol.2006.04.043

Liao, Hua-Xin, Laura L. Sutherland, Shi-Mao Xia, Mary E. Brock, Richard M. Scearce, Stacie Vanleeuwen, S Munir Alam, et al. “A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses.” Virology 353, no. 2 (September 30, 2006): 268–82. https://doi.org/10.1016/j.virol.2006.04.043.

Liao H-X, Sutherland LL, Xia S-M, Brock ME, Scearce RM, Vanleeuwen S, et al. A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses. Virology. 2006 Sep 30;353(2):268–82.

Liao, Hua-Xin, et al. “A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses.” Virology, vol. 353, no. 2, Sept. 2006, pp. 268–82. Pubmed, doi:10.1016/j.virol.2006.04.043.

Liao H-X, Sutherland LL, Xia S-M, Brock ME, Scearce RM, Vanleeuwen S, Alam SM, McAdams M, Weaver EA, Camacho Z, Ma B-J, Li Y, Decker JM, Nabel GJ, Montefiori DC, Hahn BH, Korber BT, Gao F, Haynes BF. A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses. Virology. 2006 Sep 30;353(2):268–282.

Published In

Virology

DOI

10.1016/j.virol.2006.04.043

ISSN

0042-6822

Publication Date

September 30, 2006

Volume

353

Issue

Start / End Page

268 / 282

Location

United States

Related Subject Headings

env Gene Products, Human Immunodeficiency Virus
Virology
Neutralization Tests
Molecular Sequence Data
Immunophenotyping
HIV-1
HIV Infections
HIV Antibodies
Guinea Pigs
Gene Products, env