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Survival after lung transplantation of cystic fibrosis patients infected with Burkholderia cepacia complex.

Publication ,  Journal Article
Alexander, BD; Petzold, EW; Reller, LB; Palmer, SM; Davis, RD; Woods, CW; Lipuma, JJ
Published in: Am J Transplant
May 2008

Within the Burkholderia cepacia complex (Bcc), B. cenocepacia portends increased mortality compared with other species. We investigated the impact of Bcc infection on mortality and re-infection following lung transplant (LT). Species designation for isolates from Bcc-infected patients was determined using 16S rDNA and recA gene analyses. Of 75 cystic fibrosis patients undergoing LT from September 1992 to August 2002, 59 had no Bcc and 16 had Bcc (including 7 B. cenocepacia) isolated in the year before LT. Of the latter, 87.5% had Bcc recovered after transplantation, and all retained their pretransplant strains. Survival was 97%, 92%, 76% and 63% for noninfected patients; 89%, 89%, 67% and 56% for patients infected with Bcc species other than B. cenocepacia; and 71%, 29%, 29% and 29% for patients with B. cenocepacia (p = 0.014) at 1 month, 1 year, 3 years and 5 years, respectively. Patients infected with B. cenocepacia before transplant were six times more likely to die within 1 year of transplant than those infected with other Bcc species (p = 0.04) and eight times than noninfected patients (p < 0.00005). Following LT, infection with Bcc species other than B. cenocepacia does not significantly impact 5-year survival whereas infection with B. cenocepacia pretransplant is associated with decreased survival.

Duke Scholars

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

May 2008

Volume

8

Issue

5

Start / End Page

1025 / 1030

Location

United States

Related Subject Headings

  • Survivors
  • Survival Analysis
  • Surgery
  • Retrospective Studies
  • Respiration, Artificial
  • Postoperative Complications
  • Male
  • Lung Transplantation
  • Humans
  • Female
 

Citation

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Alexander, B. D., Petzold, E. W., Reller, L. B., Palmer, S. M., Davis, R. D., Woods, C. W., & Lipuma, J. J. (2008). Survival after lung transplantation of cystic fibrosis patients infected with Burkholderia cepacia complex. Am J Transplant, 8(5), 1025–1030. https://doi.org/10.1111/j.1600-6143.2008.02186.x
Alexander, B. D., E. W. Petzold, L. B. Reller, S. M. Palmer, R. D. Davis, C. W. Woods, and J. J. Lipuma. “Survival after lung transplantation of cystic fibrosis patients infected with Burkholderia cepacia complex.Am J Transplant 8, no. 5 (May 2008): 1025–30. https://doi.org/10.1111/j.1600-6143.2008.02186.x.
Alexander BD, Petzold EW, Reller LB, Palmer SM, Davis RD, Woods CW, et al. Survival after lung transplantation of cystic fibrosis patients infected with Burkholderia cepacia complex. Am J Transplant. 2008 May;8(5):1025–30.
Alexander, B. D., et al. “Survival after lung transplantation of cystic fibrosis patients infected with Burkholderia cepacia complex.Am J Transplant, vol. 8, no. 5, May 2008, pp. 1025–30. Pubmed, doi:10.1111/j.1600-6143.2008.02186.x.
Alexander BD, Petzold EW, Reller LB, Palmer SM, Davis RD, Woods CW, Lipuma JJ. Survival after lung transplantation of cystic fibrosis patients infected with Burkholderia cepacia complex. Am J Transplant. 2008 May;8(5):1025–1030.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

May 2008

Volume

8

Issue

5

Start / End Page

1025 / 1030

Location

United States

Related Subject Headings

  • Survivors
  • Survival Analysis
  • Surgery
  • Retrospective Studies
  • Respiration, Artificial
  • Postoperative Complications
  • Male
  • Lung Transplantation
  • Humans
  • Female